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Plants are a great source of medicines, especially in traditional medicine, which are useful in the treatment of various diseases. Tylophora indica is a climbing perennial plant indigenous to India. It is grows wild in the southern and eastern region. It has longstanding reputation as a remedy for asthma. The leaves of Tylophora indica are included in Bengal pharmacopeia since 1884. It is said to have laxative, expectorant, diaphoretic (Sweating) and purgative (Vomiting) properties. It has been used for the treatment of various respiratory problems. It has reputation as an alternative and as a blood purifier, often used in rheumatism and syphilitic rheumatism. Root or leaf powder is used in diarrohea, dysentery and intermittent fever. It is an expectorant and administered in respiratory infections, bronchitis and whooping cough. Dried leaves are emetic, diaphoretic and expectorant. It is regarded as one of the best indigenous substitute for ipecacuanha, so it was considered as Indian ipecacuahna in the latter half of the 19th century. Other problems including allergies, bronchitis and colds, as well as dysentery and osteoarthritis pain. Tylophora has increasingly popular for treatment in asthma, based on its traditional use for this purpose. Tylophora indica is also still recommended for some of its other traditional uses, including hay fever, bronchitis and the common cold. [ABSTRACT FROM AUTHOR]

Aim: This study was designed to assess the efficacy and safety of Saccharomyces cerevisiae variant boulardii CNCM I-3799 (S. boulardii CNCM I-3799) in the management of acute diarrhea in children., Methods: A total of 100 infants and children 3-36 months of age with acute diarrhea received medical care according to the World Health Organization guidelines on the management of acute diarrhea in children and were randomly allocated to the probiotic group (S. boulardii CNCM I-3799 at a daily dose of 5 billion CFU twice daily) or to the placebo group. Infants and children were treated for 5 days and an extended follow-up was planned 1 and 2 months after the end of the treatment period. Primary endpoint was the time of recovery from diarrhea defined as the duration of diarrhea. Other parameters, such as frequency and consistency of stools, associated with the severity of diarrhea episodes were defined as secondary endpoints., Results: The administration of S. boulardii CNCM I-3799 was associated with beneficial effects on duration and severity of diarrhea. The time of recovery from diarrhea was significantly shorter in the probiotic group compared with the placebo group (65.8 ± 12 hours vs. 95.3 ± 17.6 hours, P = 0.0001). Faster remission in the probiotic group was also demonstrated by a shorter time before the first episode of semisolid stool [-23.5 hours, diff (95% CI): -7.99 (-31.49 to -15.51), P = 0.0001] and the faster normalization of stool consistency. S. boulardii CNCM I-3799 was well tolerated., Conclusion: S. boulardii CNCM I-3799 supplementation in children with acute diarrhea was shown effective in reducing the duration and severity of diarrhea in infants and children.