1. Mannose-binding Lectin (MBL) as a susceptible host factor influencing Indian Visceral Leishmaniasis.
- Author
-
Mishra A, Antony JS, Gai P, Sundaravadivel P, Van TH, Jha AN, Singh L, Velavan TP, and Thangaraj K
- Subjects
- Case-Control Studies, Cross-Sectional Studies, Female, Gene Frequency genetics, Genotype, Humans, India, Leishmaniasis, Visceral parasitology, Leishmaniasis, Visceral pathology, Male, Mannose-Binding Lectin metabolism, Polymorphism, Single Nucleotide genetics, Promoter Regions, Genetic genetics, Complement System Proteins immunology, Leishmania donovani immunology, Leishmaniasis, Visceral immunology, Mannose-Binding Lectin blood, Mannose-Binding Lectin genetics
- Abstract
Visceral Leishmaniasis (VL), caused by Leishmania donovani is endemic in the Indian sub-continent. Mannose-binding Lectin (MBL) is a complement lectin protein that binds to the surface of Leishmania promastigotes and results in activation of the complement lectin cascade. We utilized samples of 218 VL patients and 215 healthy controls from an Indian population. MBL2 functional variants were genotyped and the circulating MBL serum levels were measured. MBL serum levels were elevated in patients compared to the healthy controls (adjusted P=0.007). The MBL2 promoter variants -78C/T and +4P/Q were significantly associated with relative protection to VL (-78C/T, OR=0.7, 95% CI=0.5-0.96, adjusted P=0.026 and +4P/Q, OR=0.66, 95% CI=0.48-0.9, adjusted P=0.012). MBL2*LYQA haplotypes occurred frequently among controls (OR=0.69, 95% CI=0.5-0.97, adjusted P=0.034). MBL recognizes Leishmania and plays a relative role in establishing L. donovani infection and subsequent disease progression. In conclusion, MBL2 functional variants were associated with VL., (Copyright © 2015 Elsevier Ireland Ltd. All rights reserved.)
- Published
- 2015
- Full Text
- View/download PDF