1. Two new bisindole alkaloids from Tabernaemontana macrocarpa Jack.
- Author
-
Amelia P, Nugroho AE, Hirasawa Y, Kaneda T, Tougan T, Horii T, and Morita H
- Subjects
- Alkaloids pharmacology, Antimalarials pharmacology, Drug Screening Assays, Antitumor, Indole Alkaloids, Indonesia, Molecular Structure, Plant Bark chemistry, Plasmodium falciparum drug effects, Alkaloids chemistry, Antimalarials chemistry, Tabernaemontana chemistry
- Abstract
Two new bisindole alkaloids, bisnaecarpamines A (1) and B (2), possessing a vobasine-sarpagine type skeleton were isolated from the bark of Tabernaemontana macrocarpa Jack. Their structures were elucidated by extensive spectroscopic methods and chemical correlation. The absolute configurations of compounds 1 and 2 were established using TDDFT-ECD calculation of the selected isomers. Bisnaecarpamine A exhibited potent antimalarial activity against Plasmodium falciparum 3D7 strain with IC
50 value of 28.8 µM.- Published
- 2021
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