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• PPR is a highly contagious disease of small ruminants, the natural host. • Evaluation of camel susceptibility by an experimental infection. • PPRV virulent strain belonging to lineage IV was used for infection. • Our study showed that dromedary camels are not sensitive to PPR after infection by a highly virulent isolate (Morocco 2015). • Serology results confirm replication of the virus and antibody response without shedding (negative PCR results on swabs). Peste des Petits Ruminants Virus (PPRV) causes a severe contagious disease of sheep and goats and has spread extensively in last years through Asia and Africa. PPRV, known to infect exclusively small ruminants, has been recently reported in camels in Iran and Sudan. Reported clinical symptoms are similar to those observed in small ruminants, fatality rate still unknown. However most of the authors reported seropositive camels without clinical signs. Camel sensitivity to PPRV is still controversial and more investigation need to be performed. In this study, we tested camel susceptibility by an experimental infection using a virulent PPRV strain belonging to lineage IV. Young dromedary camels were infected intravenously and observed one month for clinical symptoms. Viraemia and virus secretion charge in swabs were evaluated by PCR. Seroconversion was assessed by ELISA and virus neutralisation test. Infected animals did not manifest any clinical symptoms of the disease and no virus was detected in secretions. Seroconversion was observed from day 14 post infection. [ABSTRACT FROM AUTHOR]