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Land surface temperature (LST) and vegetation cover changes are two indicators of landscapes in a region. The relationship between LST anomalies, elevation, vegetation, and urban growth is significant to conservation. This study addresses this issue using night-time satellite imagery, kernel methods (points aggregation), and the trend analysis for a long-term period (2001–2017) in Iran. Variables for two seasons (summer and winter) in urban and natural land uses were derived using the Google Earth Engine (GEE) and NASA's Giovanni. Point data derived from raster maps were quantified using statistical kernel and trend analysis. As result, it was observed that LST rise in various elevations, seasons, and land uses. The LST was analyzed through kernels (point aggregation in scatter graphs), which shifted to the right. The LST anomaly in the daytime had the highest maximum value (>4 °C) and lowest minimum value (<-5 °C) in forests and mountains and metropolises with the highest population growth rate. Summer and winter seasons had positive trends in LST for forest and mountain land uses. All seasons had positive trends in EVI in the mountain, and desert land uses. This warming and increasing LST can increase vulnerability to drought, dust storms, floods, avalanches, and natural fires. The EVI is increasing over the years due to government projects in green spaces and urban parks. There is a need to protect urban and natural environments to prevent natural disasters and unplanned population growth. • Google Earth Engine (GEE) is used to analyze remote sensed data. • New workflow with open access data was developed to analyze LST and land use. • The relationship between LST and land use over a long term were significant. • Kernel points from imagery were analyzed using trend and statistical analysis. • The implication of climate change varied by land use and elevation in the study area. [ABSTRACT FROM AUTHOR]