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Statement of the Problem: The prevalence of oral and maxillofacial lesions differs in various populations and is an important concern for health care providers. Purpose: The present study aimed to evaluate the relative frequency and distribution of oral and maxillofacial lesions in patients referred to the Department of Oral and Maxillofacial Pathology, Kerman Faculty of Dentistry in southeast Iran. Materials and Method: In the present retrospective study, the collected data consisted of age, gender, lesion location, and the clinical and histopathological diagnoses of all the biopsy samples diagnosed in 23 years (1997–2020). The data were analyzed with SPSS 22, using the chi-squared test and ANOVA (p< 0.05). Results: From 2092 lesions with a definite diagnosis, 1202 (57.5%) and 890 (42.5%) cases belonged to female and male patients, respectively. The mean age of the subjects was 39.06±17.71 years, and the most frequent location of the lesions was the buccal mucosa (25.2%). The frequencies and number of non-neoplastic lesions, neoplasms, and premalignant lesions were 84% (n=1758), 13.3% (n=278), and 2.7% (n=56), respectively. Reactive lesions were the most common cases, with 34.6% (n=724), and lichen planus was the most frequent lesion with 18.1% (n=379). Squamous cell carcinoma was the most frequent lesion in patients >70 years of age (27.6 %). Conclusion: The present study provided useful data on the frequency and distribution of oral lesions over 23 years and made it possible to compare its results with those of studies carried out in other countries. Non-neoplastic lesions were the most common category, and lichen planus, pyogenic granuloma, and irritation fibroma were the most frequent lesions in descending order. [ABSTRACT FROM AUTHOR]

Background. Clinical and pathologic features of oral and maxillofacial malignant lesions are very important and useful in diagnostic and therapeutic planning. The aim of this study was to determine and compare the clinicopathologic features of different types of oral and maxillofacial cancers in Cancer Registry System at Isfahan-Iran. Methods. In this cross-sectional descriptive analytic study, required data (tumor type, tumor location, age, sex, and grade of malignancy) of 1081 patients from Isfahan Cancer Registry collected. Results. In this study, the mean age of the patients was 59.9±18.5years old. Most of the patients were male (56.43%). In this study, squamous cell carcinoma was the most common malignancy (61.9%) followed by non-Hodgkin's lymphoma (7%). The most common site was tongue (38.7%) and then the nasopharynx (13%). Also nasopharynx tumors in men were more common than women (P <0.001). Conclusion. Squamous cell carcinoma, as the most common oral and maxillofacial cancer, requires considerable attention and rapid and appropriate diagnosis and treatment. Knowing the clinical and pathological features of this cancer and risk factors can improve the prognosis of patients. [ABSTRACT FROM AUTHOR]

Background and Aim: Melanoma is a malignant neoplasm of melanocytic origin that arises from a benign melanocytic lesion or denovo from melanocytes within otherwise normal skin or mucosa. Oral mucosal melanoma is much less than %1of all melanomas. Mucosal melanoma is much more aggressive than its cutaneous counterpart. Due to a real increase in the frequency of melanoma in recent years, we investigate the prevalence of malignant melanoma in the mouth ,head and neck during a 11 years period in Iranian population.Materials and Methods: This study was done on the pathology records of patients admitted to the Department of Pathology, School of Dentistry Shahid Beheshti ,Lughman Hakim, Shohada,Taleghani hospitals and Institute cancer of Imam Khomeini. In this study the variables like gender, age, location of the lesion, recurrence and metastasis was evaluated. The chi-square test was used to analyze information obtained from the research.Result:Of the 191679 cases accessed during the 11-year period, 262(0.14%) were identified as oral& maxillofacial malignant melanomas. The average age of melanoma was 50+-11/01years and the incidence in men was higher than women. The most common clinical feature was discoloration (46.9%)and then was ulceration (18.6%).Of all cases 24.8% had metastases. The most common site was the neck and cheek, and the most common area in the mouth, was reported in palate. Conclusion:Frequency of head and neck melanoma was 0.14% of all studied cases. The most common and the least common sites were neck and chin, respectively. Most cases of oral melanoma were localized in the palate and the incidence in men was higher than women. [ABSTRACT FROM AUTHOR]