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cells, can be caused by blood loss, hemolysis, or impaired erythropoiesis. Types of anemia include iron-deficiency anemia and vitamin-deficiency anemia. Given their high iron and nutrient content, certain medicinal plants offer potential therapeutic benefits for anemia. This review aims to identify medicinal plants from Northwest Iran traditionally used for treating this condition. Methodology: To identify relevant literature, a comprehensive database search was conducted using keywords such as 'medicinal plants,' 'Iran,' 'anemia,' 'hematopoietic,' 'Urmia,' 'Tabriz,' 'Ardabil,' 'West Azerbaijan,' 'East Azerbaijan,' and 'ethnobotany. Databases such as Google Scholar, SID, Magiran, PubMed, and Scopus were used to search for relevant articles, particularly ethnobotanical studies related to the subject. Results: The review identified that medicinal plants such as Nasturtium sp., Salvia officinalis, Centaurea depressa, Centaurea virgate, Achillea biebersteinii, Cichorium intybus, Urtica dioica, Prunus cerasifera, Cichorium intybus, Saponaria officinalis, Foeniculum vulgare, Achillea millefolium, Berberis vulgaris, Capsella bursa-pastoris, Crataegus aronia, Adiantum capillus-Veneris, Anthemis cotula, Gandelia tourenfortii, Rheus ribes, Lactuca virosa, Hyssopus officinale, and Salix alba are used in traditional and ethnobotanical practices to treat anemia. Conclusion: Further research is recommended to conduct phytochemical analysis of these medicinal plants, identifying the active compounds that influence anemia and hematopoiesis. Additionally, clinical trials involving animal and human models could explore the potential of these plants as a basis for developing effective and affordable herbal combination drugs for the treatment of anemia. [ABSTRACT FROM AUTHOR]

Here we report a 5-year-old male diagnosed with acquired Severe Aplastic anemia (SAA) who underwent the first successful autologous cord blood transplant in Iran. Due to an ongoing requirement for transfusion support and the lack of a sibling donor we decided to do hematopoietic stem cell transplantation (HSCT) by using an autologous cord blood unit your own patient was found to be available in the private cord blood bank. Surprisingly platelet engraftment was occurred four weeks after infusing the cells. He is well completely for clinical and hematologic view 12 weeks after doing transplant and this remained stable until now (48 months after HSCT) despite Sandimmune discontinuation completely. These findings suggest that for the patient with a diagnosis of acquired SAA autologous cord blood HSCT should be considered if available before considering unrelated donor HSCT. [ABSTRACT FROM AUTHOR]

Abstract: Sulfur mustard (SM) is highly toxic for various organs. The eyes, skin, respiratory tract, as well hematopoietic and immune systems are the main organs affected by SM. Granulocyte-macrophage colony stimulating factor (GM-CSF) is a potent cytokine that plays an important role in the hematopoietic and immune system. The aim of this study was to determine the serum levels of GM-CSF and its relation to blood cell count and other inflammatory cytokines 20years after SM exposure. The association of GM-CSF with the clinical severity of pulmonary, ophthalmic and dermatologic complications has also been studied. In this historical cohort study named as Sardasht-Iran Cohort Study (SICS), 369 SM exposed male participants and 125 unexposed volunteers were studied. The serum concentrations of cytokines were measured by ELISA technique. The severity of clinical complications was graded according to the criteria verified by the Medical Committee of the Foundation of Martyr and Veterans Affairs. The serum levels of GM-CSF in the SM exposed group did not display any significant differences with the control group. Median of GM-CSF was 7.33 and 9.39pg/ml in the SM exposed group and the controls respectively. There was a positive correlation between the serum levels of GM-CSF and the percent of eosinophils only in the exposed group. Moreover, positive correlations were found between circulating levels of GM-CSF with IL-1α, IL-1β, TNF-α and IL-6. This correlation was not observed between GM-CSF and IL-8 in both study groups. The serum levels of GM-CSF did not show any significant association with clinical complications. [Copyright &y& Elsevier]