1. Ethnic variation in toxicity and outcome of adjuvant chemoradiation for gastric cancer in Israel.
- Author
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Brenner RM, Kivity S, Kundel Y, Purim O, Peled N, Idelevich E, Lavrenkov K, Kovel S, Fenig E, Sulkes A, and Brenner B
- Subjects
- Adenocarcinoma ethnology, Adenocarcinoma therapy, Adult, Aged, Aged, 80 and over, Chemoradiotherapy, Adjuvant mortality, Female, Follow-Up Studies, Gastrointestinal Diseases ethnology, Gastrointestinal Diseases etiology, Hematologic Diseases ethnology, Hematologic Diseases etiology, Humans, Israel, Male, Middle Aged, Neoplasm Grading, Neoplasm Staging, Prognosis, Stomach Neoplasms ethnology, Stomach Neoplasms therapy, Survival Rate, Young Adult, Adenocarcinoma complications, Chemoradiotherapy, Adjuvant adverse effects, Ethnicity statistics & numerical data, Gastrointestinal Diseases mortality, Hematologic Diseases mortality, Stomach Neoplasms complications
- Abstract
Background: Data on differences in toxicity and efficacy of chemotherapy and radiotherapy among different ethnic groups is limited. We evaluated differences in toxicity, tolerability and clinical outcome of Ashkenazi and non-Ashkenazi Jews receiving postoperative chemoradiation for locally advanced gastric cancer (LAGC)., Patients and Methods: Between 6/2000-12/2007, 84 Ashkenazi patients and 60 non-Ashkenazi patients underwent chemoradiation following resection of LAGC (INT-116 trial)., Results: Patients' and tumor characteristics were comparable. Ashkenazi patients experienced significantly higher rates of fatigue, anorexia, and grade 3-4 dysphagia, as well as a trend for a higher rate of diarrhea. The incidence of other toxicities, dose adjustments of chemotherapy and radiotherapy and patient prognosis did not differ., Conclusion: This study shows higher rates of various toxicities among Ashkenazi patients receiving postoperative chemoradiation for LAGC compared to non-Ashkenazi patients. To our knowledge, this is the first study comparing treatment toxicity, tolerability and outcome between these two groups.
- Published
- 2013