1. Antiperinuclear factor--clinical, serological and genetic correlates in Israeli patients with rheumatoid arthritis.
- Author
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Tishler M, Maran R, Langevitz P, Livneh A, Gazit E, Gilburd B, Youinou P, and Shoenfeld Y
- Subjects
- Adult, Aged, Aged, 80 and over, Antibodies, Antinuclear genetics, Arthritis, Rheumatoid ethnology, Arthritis, Rheumatoid genetics, Female, HLA-DR1 Antigen genetics, HLA-DR4 Antigen genetics, Humans, Israel ethnology, Male, Middle Aged, Rheumatoid Factor analysis, Rheumatoid Factor genetics, Severity of Illness Index, Antibodies, Antinuclear analysis, Arthritis, Rheumatoid immunology, HLA-DR1 Antigen analysis, HLA-DR4 Antigen analysis
- Abstract
The possible association between the presence of antiperinuclear factor (APF) and clinical and genetic parameters was investigated in 54 Israeli patients with rheumatoid arthritis (RA). Rheumatoid factor (RF) was detected in the sera of 43 patients (80%) and APF was positive in 33 (61%). No significant statistical differences were found in the presence of HLA-DR4 and/or DR1 between APF-positive and -negative patients. Furthermore, neither the Ritchie articular index nor the patient's functional class correlated with the presence of APF. The results of our study suggested that although Israeli patients have a different genetic background, the presence and behaviour of APF is similar to that of other Caucasian populations. more...
- Published
- 1997
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