Search

Benign prostatic hyperplasia (BPH) is a common urological condition affecting aging men worldwide. Among the treatment options available for BPH, transurethral resection of the prostate (TURP) is the gold-standard invasive intervention. To reduce the TURP-related non-negligible morbidity, loss-of-ejaculation rate, hospitalization, blood loss and catheterization time several laser techniques have been developed, such as the Thulium Laser Enucleation of the Prostate (ThuLEP). To investigate the efficacy outcomes of the ThuLEP as a treatment option for benign prostatic hyperplasia (BPH) we performed a retrospective observational study at Moriggia Pelascini Hospital (Como, Italy) between January 2015 and September 2018. We included 265 patients who underwent ThuLEP at a specific hospital between defined dates. Data on various parameters, including post-void residue volume, peak urinary flow rate (Qmax), International Prostate Symptom Score (IPSS) for urinary symptoms, IPSS Quality of Life (QoL) score, and International Index of Erectile Function (IIEF) score for erectile dysfunction, were collected at baseline and follow-up. The analysis revealed significant improvements in voiding efficiency, urinary flow, urinary symptoms, quality of life, and erectile function following ThuLEP. Furthermore, certain baseline characteristics, such as post-void residue, peak urinary flow rate, age, prostate volume, and aspirin usage, were found to influence treatment outcomes. Despite the study's limitations, these findings contribute to understanding ThuLEP's effectiveness in managing BPH and can aid in making informed clinical decisions for patient care. Prospective studies with longer follow-up periods are recommended to validate and extend these results. [ABSTRACT FROM AUTHOR]

We sought to investigate epidemiology, risk factors, clinical features, and outcome of the C. parapsilosis blood stream infection (BSI) outbreaks observed during the first surges of COVID-19 pandemic in our population. Retrospective, monocentric observational study in the 24 bed intensive care unit (ICU) of a tertiary care medical center in northern Italy, from 2019 to 2021 first 5 months. 2030 patients were enrolled, of whom 239 were COVID-19 positive. The total incidence of Candida-BSI was 41.9 per 1000 admissions, with two outbreaks during 2020 spring and winter's COVID surges. The total numbers of C. parapsilosis BSI cases are 94, of which 21 during the first outbreak and 20 during the second. In our population, COVID-19 was strongly associated with C. parapsilosis BSI (OR 4.71, p < 0.001), as well as continuous renal replacement therapy (CRRT) (OR 3.44, p = 0.001), prolonged antibiotic therapy (OR 3.19, p = 0.004), and delayed infusion sets replacements (OR 2.76, p = 0.015). No statistically significant association was found between Candida-BSI episodes and mortality, when adjusted for other known outcome risk factors. COVID surges undermined the infectious control measures in our ICU, leading to two outbreak of C. parapsilosis BSI. A stricter, thorough management of intravascular devices and infusion set is crucial in prevention of catheter related BSI, and awareness must be kept high, especially in emergencies circumstances, such as the ongoing COVID-19 pandemic. [ABSTRACT FROM AUTHOR]

Fish roe are not yet described as triggers of allergic reactions in Italy, especially during the pediatric age; they are more frequently involved in anaphylaxis in Eastern countries, such as Japan. For this report, we reported a case of anaphylaxis in a 2-year-old boy admitted to our Hospital Pediatric Emergency Room with a suspected allergic reaction. 15 min after the meal, he presented generalized urticaria, angioedema, wheezing, sneezing, and two vomiting episodes. The meal was smoked salmon, butter, mayonnaise, anchovies, and fish roe (salmon and lumpfish roe). Tryptase serum levels presented as elevated in the acute phase and normal after 24 h. Serum food-specific IgE tested negative for salmon and other fish, such as skin prick tests. Serum food-specific IgE showed that the patient was sensitized to cow's milk and eggs, but he doesn't have a food allergy. He had regularly consumed milk and eggs before and after the allergic reaction without clinical problems. A prick-by-prick test resulted positive for fish roe (salmon and lumpfish roe). Based on patient's history, allergy test results in vivo, and tryptase serum levels, the diagnosis of anaphylaxis induced by fish roe was confirmed. In conclusion, to the best of our knowledge, this is the first pediatric case of fish roe-induced anaphylaxis reported in Italy. [ABSTRACT FROM AUTHOR]

In the last two decades Pinna nobilis, the largest bivalve mollusk endemic to the Mediterranean Sea, has recolonized the tidal flats of some coastal lagoons along the Italian Adriatic coast. In this study, we investigate the influence of tides on the spatial distribution and density of a P. nobilis population developing on a tidal flat of the Venice lagoon (NE Italy) by exploiting remote sensing technologies. Our results show that there is a threshold topographic elevation (about 0.5 m below mean sea level for the studied tidal flat) above which the number and duration of emersions become limiting factors of P. nobilis abundance. Above this elevation, the population density decreases sharply. Densely populated areas tend to occur in tidal flat depressions, where the duration and frequency of emersions are low. We find, however, that the population density has large spatial variability in response to other factors, such as the seagrass percentage cover. The density of the shells increases with increasing seagrass percentage cover, and the dense P. nobilis population (0.8–2.68 N/m2) grows within the Cymodocea nodosa meadow that has a high seagrass percentage cover (>85%). However, within the seagrass meadow with the highest percentage cover, the bivalve preferentially colonizes the portion closest to the main channel, a possible source of nutrients. The shift to C. nodosa—dominated meadows in the Venice lagoon occurred during the last two decades has probably facilitated the observed colonization by P. nobilis. Our findings provide management information for protection and/or restoration of P. nobilis in coastal lagoons. Plain Language Summary: Pinna nobilis is the largest mollusk of the Mediterranean Sea and strictly protected by European laws. Recently this species has been attacked by pathogens which are causing mass mortality events. In early 2021, the P. nobilis population of the Venice lagoon (Italy) was attacked and is in risk of disappearing. Thanks to a survey performed using a drone in the summer of 2020, we studied the pre‐epidemic distribution of the P. nobilis population colonizing a tidal flat. We found that exposure to limited emersions is a key factor for the bivalve survival as emersions can cause desiccation. Another key factor is the seagrass percentage cover: P. nobilis tends to colonize dense portions of the seagrass meadows, often close to the channels, which are a potential source of food. Until early 2021, when the pathogens attacked, the population growth has been likely facilitated by a constant expansion of Cymodocea nodosa, a subtropical seagrass species. The expansion of C. nodosa has probably been promoted by a small but constant increase of the water temperature during the last two decades. Our findings provide management information for the protection and/or restoration of P. nobilis in coastal lagoons. Key Points: In tidal systems, Pinna nobilis distribution is strongly affected by the bottom topography and the duration and frequency of emersionThere is a significant positive correlation between the density of P. nobilis and seagrass coverSummer time monitoring of P. nobilis using unmanned aerial vehicles (UAVs) is not effective when the tidal flats are emerged and seagrass leaves obscure the shells [ABSTRACT FROM AUTHOR]

Background and purpose: Both baseline prognostic factors and short‐term predictors of treatment response can influence the long‐term risk of disability accumulation in patients with relapsing–remitting multiple sclerosis (RRMS). The objective was to develop and validate a scoring system combining baseline prognostic factors and 1‐year variables of treatment response into a single numeric score predicting the long‐term risk of disability. Methods: We analysed two independent datasets of patients with RRMS who started interferon beta or glatiramer acetate, had an Expanded Disability Status Scale (EDSS) score <4.0 at treatment start and were followed for at least 10 years. The first dataset ('training set') included patients attending three MS centres in Italy and served as a framework to create the so‐called RoAD score (Risk of Ambulatory Disability). The second ('validation set') included a cohort of patients followed in Barcelona, Spain, to explore the performance of the RoAD score in predicting the risk of reaching an EDSS score ≥6.0. Results: The RoAD score (ranging from 0 to 8) derived from the training set (n = 1225), was based on demographic (age), clinical baseline prognostic factors (disease duration, EDSS) and 1‐year predictors of treatment response (number of relapses, presence of gadolinium enhancement and new T2 lesions). The best cut‐off score for discriminating patients at higher risk of reaching the disability milestone was ≥4. When applied to the validation set (n = 296), patients with a RoAD score ≥4 had an approximately 4‐fold increased risk for reaching the disability milestone (p < 0.001). Discussion: The RoAD score is proposed as an useful tool to predict individual prognosis and optimize treatment strategy of patients with RRMS. [ABSTRACT FROM AUTHOR]

Background: The Work Ability in Natalizumab-Treated MS Patients (WANT) study assessed work ability, quality of life, and cognitive processing speed during natalizumab treatment. Methods: WANT was a 1-year, prospective, multicenter observational study conducted in Italy. Inclusion criteria included relapsing-remitting multiple sclerosis (MS), natalizumab treatment, full-time worker status, and loss of working hours due to MS as measured by the Work Productivity and Activity Impairment Questionnaire for MS (WPAI:MS). The primary endpoint was change in WPAI:MS domain scores after 1 year on natalizumab. Secondary endpoints included change in annualized relapse rate (ARR), Multiple Sclerosis Impact Scale (MSIS-29) score, and Symbol Digit Modalities Test (SDMT) score. Results: At enrollment, the 91 patients had a mean age of 38.3 (standard deviation [SD], 9.0) years and a mean ARR of 1.5 (SD, 0.8). After 1 year, improvements were observed in all WPAI:MS domains, with significant reductions in Absenteeism (−4.2 [SD, 26.0], p = 0.0190) and Work Productivity Loss (−7.2 [SD, 28.6]; p = 0.0456). These changes were accompanied by a low ARR (0.1), and 87.9% of patients were relapse free. Significant improvement was observed in MSIS-29 physical and psychological domains (reductions of 2.8 [SD, 11.6; p = 0.0295] and 6.3 [SD, 15.6; p = 0.0007], respectively) and SDMT score (increase of 2.4 [SD, 7.9; p = 0.0006]). Adverse events were reported in 32 of 104 patients (30.8%). Conclusions: The reductions in Absenteeism and Work Productivity Loss and the improved physical and psychological functioning reported after 1 year of natalizumab treatment in real-world settings extend our understanding of natalizumab's effects on patient-centric and health economics outcomes. [ABSTRACT FROM AUTHOR]

Background: Cardiovascular disease (CVD) is one of the main causes of mortality and morbidity in Italy. Hypercholesterolemia is a modifiable CVD risk factor. The detection and treatment of hypercholesterolemia can modify the natural history of CVD, making CVD risk for affected patients comparable to that of unaffected ones. In this scenario, the detection of families at high cardiovascular risk is the first step of CVD prevention. This multicenter, observational study is aimed at finding an effective and non-invasive screening strategy to detect families at high risk for CVD. Methods: A survey investigating the knowledge of lipid and CVD issues was distributed to the parents of all infants born at the Neonatology Unit of Piacenza City Hospital and San Paolo Hospital in Milan over a 6 months period. Overall, 554 surveys have been collected. Results: 26.8% newborns had parents who knew their own lipid profile, 40.2% had parents who knew the correct normal blood values of total cholesterol, 37.1% had parents who declared to have first or second degree relatives with lipid disorders, 33.7% had parents who declared to have first or second degree relatives with premature CVD Conclusion: Collecting a problem-tailored and accurate family history seems to be a good strategy to detect high risk families. Our data suggest that the percentage of adults who are unaware of their lipid profile, with a positive family history for CVD and/or lipid disorders is higher than expected. As a result, even the number of undetected paediatric patients at high cardiovascular risk might be greater than expected. [ABSTRACT FROM AUTHOR]

This article considers the role of non-binding legal instruments adopted in Italy against the SARSCoV- 2 virus in the early months of 2020. To verify whether the use of such instruments restricted fundamental and human rights beyond constitutional and legal limits, the article first gives an overview of hard law measures adopted in Italy against the coronavirus. It then focuses on soft law measures, the use of which became significant only in Phase II of Italy's response to COVID-19 and argues that non-binding legal instruments provided the public with instructions on gradually returning to normal life. This contribution contains case studies on the soft law measures adopted in relation to private economic enterprise and freedom of worship. Italian soft law deployed during the COVID-19 epidemic was borne out of coordination between the state and the Regions and as the result of (even informal) dialogue with the relevant stakeholders. Despite some criticism of the soft law measures used, their role in restricting constitutionally granted rights was marginal, because only hard law measures adopted nationally and locally limited personal rights and freedoms in order to contain the pandemic. [ABSTRACT FROM AUTHOR]

Background: Gait re-education is a primary rehabilitation goal after stroke. In the last decades, robots with different mechanical structures have been extensively used in the clinical practice for gait training of stroke survivors. However, the effectiveness of robotic training is still controversial, especially for chronic subjects. In this study, we investigated the short-term effects of gait training assisted by an endpoint robot in a population of chronic stroke survivors. Methods: Subjects were evaluated before and after training with clinical scales and instrumented gait analysis. Our primary outcome indicator was the walking speed. Next, we investigated the changes in kinetic and kinematic gait patterns as well as the intersegmental coordination at the level of the lower limbs. Results: Most subjects improved their speed in over-ground walking, by modifying the temporal more than the spatial gait parameters. These changes led to an improvement in the ankle power for both sides and to a slight reduction of the inclination of the pelvis during the swing phase, mainly due to a decreased knee flexion and an increased hip extension on the unimpaired leg. Conclusions: These results indicate that the proposed training induced mainly a functional change rather than an improvement of the quality of gait. Gait re-education is a primary goal in stroke rehabilitation. Nowadays several robotic devices for gait rehabilitation are used in the clinical practice, but their effectiveness is controversial, especially for chronic survivors. After a 20-session training with an endpoint robot the chronic stroke survivors showed an improvement in overground gait speed. The increased gait speed was mainly due to functional changes of the temporal parameters and of the kinetic variables at the level of both ankle joints, as well as to a reduction of compensatory strategies observable in the unimpaired side. [ABSTRACT FROM AUTHOR]

Though recent progress in multiple sclerosis (MS) treatment is remarkable, numerous unmet needs remain to be addressed often inducing patients to look for complementary and alternative medicines (CAM), especially herbal remedies (HR). HR use, scarcely investigated in MS, may cause adverse reactions (AR) and interfere with conventional treatment. We performed a survey aimed at evaluating use and attitudes towards HR and factor associated to HR use. Other CAM use and attitudes have been investigated as well. Multiple-choice questionnaires were distributed to MS out patients attending 14 Italian referral Centers. Multivariable logistic regression was used to identify HR use determinants. Present/past HR use for either MS or other diseases was reported in 35.6 % of 2419 cases (95 % CI 36.0-40.0 %). CAM use was reported in 42.5 % of cases. Independent predictors of HR use were represented by higher education, geographic area, dissatisfaction with conventional treatment of diseases other than MS and benefit perception from CAM use. Both HR and CAM use were not always disclosed to the healthcare professional. In conclusion, HR and other CAM appear to be popular among MS patients. The involvement of the healthcare professionals appears to be scarce with potential risk of AR or interference with conventional treatments. [ABSTRACT FROM AUTHOR]

The objectives of this study were to determine the effectiveness of a programme of prevention exercises conducted in a corporate environment in poultry industry slaughterers suffering from musculoskeletal disorders. Forty workers, 70% female (mean ± SD age: 44.4 ± 8.4 years) were consecutively, in an alternative way, assigned to one of two groups receiving either set of 10 sessions (experimental or control group). The experimental group followed an exercise programme for a period of five weeks and a protocol of home exercises. The control group performed the exercise protocol only at home. The Roland Morris Disability Questionnaire (RMDQ) and the Oswestry Disability Index (ODI) to measure disability, the Visual Analogue Scale (VAS) score and the Pain Drawing to measure pain were used as outcome evaluations. A significant effect of time interaction (all P <0.001 and; F = 40.673; F = 33.907 and F = 25.447) existed for lumbar VAS, RMDQ and ODI immediately after the intervention (all P < 0.006). No significant group effect or group-by-time interaction was detected for any of them, which suggests that both groups improved in the same way. This study shows that a programme of prevention exercises may have a positive effect in improving musculoskeletal disorders of slaughterhouse workers. Pain decreased in the lumbar region, and there was an almost significant reduction in disability. Copyright © 2014 John Wiley & Sons, Ltd. [ABSTRACT FROM AUTHOR]

The article explores the ideological evolution of the New Right school of political thought and theory in France and Italy. The author reflects on historiographical approaches to the methodology of the New Right. Emphasis is given to the idea of metapolitics and the heterogeneity of radicalism in relation to its national context of origin.

ABSTRACT A slow moving compound rock slide located in the northern Apennines of Italy was mapped and monitored through the integration of Airborne Laser Scanning (ALS), multi-temporal long-range Terrestrial Laser Scanning (TLS), and Automated Total Station (ATS) measurements. Landslide features were mapped using a High Resolution Digital Terrain Model (HR-DTM) obtained by merging ALS and TLS data in an Iterative Closest Point (ICP) procedure. Slope movements in the order of centimeters to a few decimeters were quantified with Differential TLS (D-TLS) based on a Surface Matching approach and supported by ATS data to define stable reference surfaces. The integrated approach allowed mapping of the composite geomorphic features of the rock slide under examination, revealing its complex dynamic nature and further proving that laser scanning is a versatile and widely applicable tool for slope process analysis. Copyright © 2013 John Wiley & Sons, Ltd. [ABSTRACT FROM AUTHOR]

The study analyses spatial and temporal patterns of drought in an area with a wide range of precipitation characteristics (the Calabria region in southern Italy) during the period 1921-2007. The short-time (2, 3 and 6 months) Standardised Precipitation Index (SPI) was estimated to analyse drought especially from the agricultural point of view. Principal component analysis (PCA) was applied to the SPI to assess the spatial variability of drought. During the period of observation, moderate to severe drought occurred at a frequency of almost 13 % in wet seasons (autumn and winter). Almost half of the region was affected by drought in the years 1981-1990 when the area experienced its most severe drought. Although the spatial patterns of drought estimated by PCA were logical and consistent with precipitation distribution, very complex patterns were observed for all the time scales looked at. The high fragmentation of the maps obtained makes them of limited value, and caution is recommended in classifying the region into homogeneous areas. [ABSTRACT FROM AUTHOR]

In the 1780s and 1790s, Pietro Verri (1728–97) wrote a large number of autobiographical and political texts, which have only recently been collected and printed in two volumes of the Edizione Nazionale of Verri's works. These writings are examined in this essay as documents of a turn from enlightened absolutism to liberalism and democracy in Italy towards the end of the eighteenth century. Verri's acceptance of the principles of liberty and equality proclaimed by the French revolutionaries was made easier by his dissatisfaction with the authoritarian and bureaucratic nature of many of Joseph II's reforms. He also came to realize that the transition of sovereignty from the prince to the people was a necessary step in the way to the unification of the Italian peninsula, which became a political and not only a cultural goal in the same years. He was aware, however, of the difficulty of spreading these views among an ignorant, backward and priest-ridden populace and thought that their education was the most important task facing Italian literati. This explains why he firmly opposed the ultra-radical propaganda of Italian jacobins in the early stages of the French occupation of Lombardy. [ABSTRACT FROM AUTHOR]

In many Mediterranean regions industrial activities have drastically affected soil evolution. As a case study, reference is made to an important Chemical Industrial District of southern Italy (Sardinia). Its setting up and development resulted in the formation of human-altered and human-transported (HAHT) soils, largely through physical-mechanical excavation, transportation and rolling out the original soils (Palexeralfs, Haploxeralfs), as well as mixing and covering them with innocuous artifacts referred to as human-transported materials (HTM). On this basis, research began with a view to evaluating the anthropogenic processes in addition to the main morphological and physical-chemical characteristics of HAHT soils as compared with reference soils (RefS), their pedovariability and the classification of HAHT soils through Soil Taxonomy. The anthro-pedoturbation induced by mixing HTM to preexisting-presently buried- soils has dramatically disturbed the "natural" pedogenetic evolution, and driven the pro-isotropic processes leading the HAHT soils to much more simplified morphology and homogenization of chemical-physical features, with an impressive loss of pedovariability. They currently meet the requirements for a "mantle" classifiable as Alfic Xerarents, as an expression of the "entisolization" that induced a taxonomic shift from Alfisols to anthropogenic Entisols. [ABSTRACT FROM AUTHOR]

The disability, cognitive impairment, fatigue and depression are interacting features in multiple sclerosis (MS), whose relation is still unclear. The objective of this study was to evaluate in a sample of MS patients, the frequency of depressive symptoms, its predicting factors and relation with cognitive impairment, fatigue and disability. 255 consecutive MS patients and 166 healthy subjects were assessed for the presence of depressive symptoms with the Beck Depression Inventory-Fast Screen (BDI-FS). Patients with BDI-FS ≥4 were further investigated for the presence of neuropsychological impairment. Depressive symptoms were significantly more frequent and severe in patients than in controls. EDSS score was the only predicting factor of depression (3.5 = threshold EDSS score for depressive symptoms) in patients, whereas neuropsychological impairment was not correlated with BDI-FS and fatigue was found to be significantly correlated with attention, executive function and memory test scores, as well as with BDI-FS score in patients. [ABSTRACT FROM AUTHOR]

Purpose: Neural tube defects, including spina bifida and anencephaly, are the second most common birth defects with an incidence in Italy of 0.4-1/1,000. Information on factors playing a role in the pathogenesis of spina bifida is based on populations with different exposures, lifestyle, social and cultural habits compared to Italian people. Our objective was to fill this gap by using data from a case-control interview study carried out at the G. Gaslini Children's Hospital, Genoa, from 2000 to 2008. Methods: We surveyed questionnaires from 133 case mothers and 273 control women providing information on periconceptional risk factors. Univariate and multivariate logistic regression analyses were used to estimate risks by odds ratios (ORs) and 95% confidence intervals (95% CIs). Results: Univariate results suggest that birth order, low maternal educational level, age, smoking habits, alcohol consumption, high caffeine intake, lack of folate supplementation, low and high calorie diet, occasional consumption of fruit and vegetables, high emotional stress, and environmental pollution are associated with an increased spina bifida risk. Nevertheless, high caffeine intake (OR = 10.82; 95% CI, 3.78-31), low calorie diet (OR = 5.15; 95%CI, 1.79-14), occasional consumption of fruit and vegetables (OR = 3.38; 95% CI, 1.67-6.82), alcohol consumption (OR = 3.05; 95% CI, 1.24-7.50) and, above all, lack of folate supplementation at any time of pregnancy (OR = 20.54; 95% CI, 5.41-77) mainly determined spina bifida risk in the multivariate analysis. Conclusion: Our findings point out that a common underlying mechanism, a disturbed folate/homocysteine metabolism, may be causative for the burden of spina bifida in the Italian population. [ABSTRACT FROM AUTHOR]

No abstract available Copyright © 2010 S. Karger AG, Basel [ABSTRACT FROM AUTHOR]

Abstract: The Volturno River plain (Campania, Italy), is an extensive alluvial formation with large pedovariability, supporting valuable crop and livestock productions. The presence of illegal waste dumps with Potentially Toxic Elements (PTEs) could threaten both environmental safety and the agricultural activities. Research is currently underway aiming to evaluate the environmental conditions and present and potential agronomic quality of the soils. This study deals with the occurrence and distribution of Pb in soils with reference to different pedological features. An extensive survey of soil profiles and core top-subsoils was carried out. Soil genesis and evolution would appear to be affected by various, mainly natural, factors, such as the variability/dynamics of sediments connected with river digression, flow regime and flooding, but also human, through the land reclamation of marsh areas. Classified pedotypes vary from Entisols to Vertisols. The former are seen in the areas near the Volturno riverbanks — frequently rejuvenated by flooding materials — the latter in stabilized inner areas that are far from riverbed. In the study area, several illegal waste dumps with toxic/harmful slag have been discovered causing a great stir and scaremongering and bringing the agricultural land image into disrepute. Despite this critical situation, soil Pb concentration in agricultural soils is low (range 0.4–90mgkg−1, mean value 21.8mgkg−1) consistent with the natural background, and below both reference literature and the contamination threshold (100mgkg−1) sanctioned by current laws. Our results also revealed that: i) Pb concentrations show wide spatial variability, and are randomly distributed among topsoils and subsoils; ii) Pb distribution along soil profiles is clearly irregular, linked to natural pedological heterogeneities, such as buried horizons and/or changes of soil organic matter (OM), clay and CaCO3 contents, and, consequently, of Cation Exchange Capacity (CEC); and iii) OM and the fine-size fraction are the main natural sinks of soil Pb. The results achieved appear to refute the alarmism concerning widespread Pb contamination in agricultural soils of Volturno River basin. [Copyright &y& Elsevier]

Background: KIF1B gene represents the first non-inflammatory gene with a putative role on axonal loss and neurodegeneration found to be associated with multiple sclerosis (MS). The objective of this study is to test the association of the rs10492972 C allelic variant of KIF1B gene in a large Italian cohort of patients with primary progressive and progressive relapsing MS (PPMS and PRMS), which represents a subtype of MS mainly driven by neurodegenerative phenomena. Methods: rs10492972 has been genotyped in an outbred sample of 222 primary PPMS and PRMS and 221 healthy controls of unique northern Italian origin using the TaqMan assay. Results: A non-significant age- and sex-adjusted odds ratio of 0.96 [95% confidence interval (CI) 0.71–1.31] has been found in C carriers, and a non-significant risk of 0.99 [95% CI 0.77–1.63] in C carriers according to a dominant model. Stratification by sex, age at onset younger than 35 years and symptoms at the onset of the disease did not reveal any significant findings. No influence on disability progression, measured with the multiple sclerosis severity score, was found in C carriers. Conclusions: These results suggest that there is no effect in carrying the rs10492972 C variant on the risk of disease as well as on the rate of disability progression in a cohort of Italian patients with PPMS and patients with PRMS. These data need to be confirmed in an independent sample of patients with progressive MS. [ABSTRACT FROM AUTHOR]

The article presents the results of a study which examines the morphological similarities of ephemeral gullies and rills found in Sicily, Italy and the researches conducted on soil content and soil erosion. Rill erosion measurements on 15 plots and ephemeral gully data on 120 hectare area reveal a high degree of morphological similarity between rill and ephemeral gullies. The dimensional analysis also showed that single relationship can be used in rill and gully measurements.

Abstract: Recent research has shown a lack of long-term monitoring for detailed analysis of gully erosion response to climate characteristics. Measures carried out from 1995 to 2007 in a wheat-cultivated area in Raddusa (Sicily, Italy), represent one of the longest series of field data on ephemeral gully, EG, erosion. The data set collected in a surface area of almost 80ha, permits analysis of the influence of rainfall on EG formation and development. Ephemeral gullies formed in the study area were measured on a yearly scale with a Post-Processing Differential GPS for length and with a steel tape for the width and depth of transversal sections. Ephemeral gully formation was observed for 8 years out of 12, which corresponds to a return period of 1.5 years. The measurements show strong temporal variability in EG erosion, in agreement with the rainfall characteristics. The total eroded volumes ranged between 0 and ca. 800m3 year−1, with a mean of ca. 420m3 year−1, corresponding to ca. 0.6kgm−2 year−1. Ephemeral gully erosion in the study area is directly and mainly controlled by rainfall events. An antecedent rainfall index, the maximum value of 3-days rainfall (H max 3_d), is the rain parameter which best accounts for EG erosion. This index is used here as a simple surrogate for soil water content. An H max 3_d threshold of 51mm was observed for EG formation. The return period of the H max 3_d threshold is almost the same as the return period for EG formation. Although a mean of seven erosive rain events were recorded in a year, EG formation and development generally occur during a single erosive event, similarly to other semiarid environments. The most critical period is that comprised between October and January, when the soil is wetter and the vegetation cover is scarce. Empirical models for EG eroded volume estimation were obtained using the data set collected at this site. A simple power-type equation is proposed to estimate the eroded volumes using H max 3_d as an independent variable. This equation shows an R 2 equal to 0.67 and a standard error of estimation of 0.79. [Copyright &y& Elsevier]

Abstract: The properties of a non-andic, allophanic Inceptisol (POM1) and two andic, non-allophanic Inceptisols (FLM5 and SPM8), representative of a toposequence on basanite rocks of Mt. St. Antonio (central-western Sardinia, Marghine sub-region), were analyzed to better elucidate factors and processes that lead to a different expression of andic properties and allophane formation in xeric Mediterranean environment. A series of laboratory techniques including physical, chemical, micromorphological, X-ray diffraction (XRD), scanning electron microscopy (SEM) analyses were used. All soils are usually rich in organic carbon, dystric at the Great Group level, with saturation base from 72 to 10%, and with pH from subalcaline to acidic. Allophanic Inceptisol appears more intensely weathered than non-allophanic Inceptisols. Volcanic glass content is, in any case, negligible. POM1, formed on the plateau, shows a shallow solum (45 cm) with A2 horizon that meets all the criteria for andic soil properties; the amounts acid oxalate-extractable Alo and Sio, together with pyrophosphate-extractable Alp, typifies such a pedon as allophanic Inceptisol (0.19

This essay surveys the main reforms carried out by the Habsburg governments in Lombardy and Tuscany from the 1730s to around 1790 in the light of recent historical literature. Venturi's biographical approach to the theme is discussed in the first part of the essay, which then sets out to compare reforming activities in the two states in the fields of the administration of justice, ecclesiastical policy, and public finance. The drive towards centralization and uniformity is identified as the main aspect of the Milan reform movement, to the liberal and humanitarian tendencies of Peter Leopold's government in Tuscany. [ABSTRACT FROM AUTHOR]

Abstract: Recent research has shown the importance of ephemeral gully (EG) erosion in the context of global erosion and, at the same time, the lack of adequate models to estimate it. At present, the ephemeral gully erosion model (EGEM) is the only conceptual model specifically developed for ephemeral gully erosion estimation. The main aim of the paper is to evaluate the performance of EGEM model adapted to local conditions compared with that of simple empirical equations. A data set of 92 ephemeral gullies formed between 1995 and 2000 in a wheat-cultivated study area in Sicily, Italy, was used for the purpose. In order to improve EGEM performance, two important adaptations were made. Both the rain distribution type and the causative rainfall of the hydrological component of EGEM were modified to reproduce local conditions. The EGEM assumption of a constant depth for the entire length of the ephemeral gully was also modified. EGEM performance was tested with two different rain distribution types, three different causative rainfalls and two different EG depths. The adaptation of the EGEM hydrological component improves the volume prediction with respect to the standard version of EGEM; the improvement is mainly due to the rain distribution type, whereas causative rainfall seems to be less important. The use of adjusted EG depths is, however, essential to minimise the errors between measured and predicted volumes. The capability of EGEM to predict the ephemeral gully cross-section is weak and non-significant relationships were found between measured and estimated width. A regression analysis between ephemeral gully-eroded volume and different morphological, topographical and hydrological parameters confirms the great importance of EG length to explain eroded volume (R2=0.64 for the simple correlation between volume and length). Considering that the adaptation of the hydrological component and the measurement of EG depths are necessary for the EG volumes estimated by EGEM to be reliable, it seems more simple, as suggested by other authors, to use empirical relations between eroded volume and length performed in different environments, until more precise physically based models are developed. [Copyright &y& Elsevier]

Agriculture is the main user of water in Italy, as in most regions of the world. Particularly in Mediterranean regions, where it is more difficult to meet the agricultural water demand with conventional resources, wastewater reuse represents a viable option. Drip irrigation is particularly suitable for wastewater reuse because it minimises the health risks to farmers and product consumers due to contact with the wastewater. The performance of drip irrigation systems using wastewater is mainly limited by emitter clogging, and this discourages farmers from introducing it. The paper gives the results of experimental trials on the behaviour of six kinds of filters (gravel media, disk and screen) and four types of drip emitters (vortex and labyrinth) using five kinds of municipal wastewater that have not undergone previous advanced treatment. The performance of the emitters and filters tested depends on the quality of the wastewater: total suspended solids and organic matter content influence the percentage of totally clogged emitters, the mean discharge emitted, the emission uniformity coefficient, and the operating time of the filter between cleaning operations. Vortex emitters were more sensitive to clogging than labyrinth emitters. The gravel media filter guaranteed the best performance, but the disk filter, which is cheaper and simpler to manage, assured performance similar to that of the gavel media filter. The test showed the importance of the technology used in manufacturing disk filters. Screen filters were shown to be unsuitable for use with wastewater, with the exception of diluted and settled wastewater. The theoretical discharge of filters, suggested by the manufacturers for clean water, is not adequate for wastewater of the kind used in the trials (suspended solids greater than 78 mg/l and BOD5 more than 25 mg/l of O2). The operating times of the filters between cleaning operations, less than 1 h in most trials, suggest the use of automatic cleaning systems. The existing clogging risk classifications proposed for clean water can only be considered reliable for wastewater when labyrinth emitters and gravel or good quality disk filters (such as Arkal) are used; they are not adequate for vortex emitters or screen filters. [Copyright &y& Elsevier]

Ephemeral gully erosion is responsible for heavy damage to agricultural land and causes sedimentation and drainage network formation in most regions. Ephemeral gully length, width and depth were measured over a 5-yr period in an area of about 120 ha of heavy soils cultivated with durum wheat in Sicily (Italy) in order to quantify the soil losses and to examine, by statistical analysis, the relationships between this kind of erosion, precipitation and the characteristics of the watersheds. Ephemeral gully formation was observed for 4 yr out of five in the study area. A mean length of about 36 m ha−1 yr−1 and mean soil losses of 3·3 m3 ha−1 yr−1 were measured. The channel depth reached a maximum value (>1 m) 3 yr out of four. In the examined soils, this kind of erosion occurs when the moisture content of the soil is high: regression analysis indicates that the soil moisture content can be expressed by the amount of precipitation for 3 days. In the observation period, the minimum 3-day rainfall which gave rise to channel formation was 51 mm; since the 51 mm return period is less than 2 yr, the risk of erosion is high. Mean depth and width, which are the channel characteristics that vary the least between the different years, seem to be controlled by the soil, crop and field characteristics, whereas the precipitation regime seems mainly to influence their number and length. Regression equations were performed to estimate ephemeral gully surface area and soil losses measuring the length alone. Length measurement by the global position system is sufficiently accurate and fast. The influence of watershed surface area and length on ephemeral gully erosion indicates that a reduction in field area and length may be an effective measure to reduce this kind of erosion. [Copyright &y& Elsevier]

Bacillus cereus has sometimes been implicated in food poisoning and in opportunistic infections of seriously ill patients. This report describes an unusual case of persistent bacteremia and multiple organ failure associated with B. cereus in a patient admitted to our institution for lung cancer. The patient was undergoing treatment with an antimicrobial agent (imipenem) that was shown to be effective against the micro-organism in vitro. No portal of entry for the strain was detected. After treatment with vancomycin, also shown to be effective in vitro, no clinical improvement was noted and the patient died. Molecular studies showed that the same strain caused an episode of pseudobacteremia in another patient admitted to the same ICU room. [ABSTRACT FROM AUTHOR]

The article examines the impact of the methylenetetra-hydrofolate dehydrogenase (MTHFD1) G1958A polymorphism on neural tube defect (NTD) risk in the Italian population consist of 95 unrelated NTD children, 42 mothers and 40 fathers. According to the authors, they found no increased risk for MTHFD1 mutant genotypes among the children and fathers.

Abstract: The present study aims to assess the evolution of different proto-horizons as embryonic soils built by pedotechnologies for the reclamation and management of derelict and damaged lands, such as abandoned quarries. The model proto-horizons were assembled by utilizing coarse limestone gravel or zeolitized Phlegraean Yellow Tuff (PYT) as mineral components and commercial compost-amendments or a phosphorite-poultry manure mixture as organic matrices for growth of a pasture-grass under controlled conditions. The evolution of the model proto-horizons was followed by an evaluation of the stability and modification of the organic matter (OM) with reference to plant development. The results suggest that the natural carbonatic substrate occurring in limestone quarries was unable to sustain significant plant growth, while the PYT was suitable and efficient as a pedogenic substrate because it supported plant growth and induced a conspicuous accumulation of OM due to root activity. In particular, OM, including humic and non-humic components, greatly increased in the PYT treatment with the phosphorite-poultry manure mixture showing a concurrent trend toward humification. Conversely, an overall tendency toward degradation of OM was detected in the PYT model proto-horizon treated with commercial compost. Feasibility estimates show that quarry restoration costs appear reasonable where environmental impacts are high. [Copyright &y& Elsevier]

Abstract: The epidemiological status of cystic echinococcosis (CE) in sheep in Sardinia over the 20 years since the last control attempt at the end of the 1980s has been assessed, comparing the results of two surveys carried out in abattoirs in southern Sardinia. In the first, conducted in 1995–1997 (5–7 years after the last control effort), CE prevalence of about 75% was observed in the 1375 sheep sampled, with intensity of 10.0 and mean abundance of 7.5. The most affected organ was the liver, whereas a large percentage of infected animals presented cysts in both the liver and lung. Overall, about 26% of parasitized sheep were found to be heavily infected and 12.15% of infected animals harboured fertile cysts. In the second survey, carried out ten years after the first, during the period 2005–2010 in absence of specific control measures, a total of 1414 sheep were examined. CE prevalence was 65%, 78% in the most rural Oristano province and 58% in the most “urbanised” province of Cagliari. Frequency of sheep infected in both the liver and lung had decreased slightly compared to the first survey, particularly in the Cagliari province, as had intensity and mean abundance, though to a lesser extent in the Oristano province. 14.6% of parasitized sheep were heavily infected, showing a general decline over the 10 years between the two surveys, particularly in the Cagliari area where the figure had more than halved. Conversely, about 14% of infected sheep hosted at least 1 fertile cyst, a slight increase compared to the 1st survey. Finally, the trend of CE transmission in Sardinian sheep according to surveys carried out from 1952 to 2010 has been analysed and the results are discussed in the light of the significant socio-economic and structural transformations that have actually modified the zoonosis scenario on the island. [Copyright &y& Elsevier]

Abstract: The prognosis for thalassemia major has dramatically improved in the last two decades. However, many transfusion-dependent patients continue to develop progressive accumulation of iron. This can lead to tissue damage and eventually death, particularly from cardiac disease. Previous studies that investigated iron chelation treatments, including retrospective and prospective non-randomised clinical trials, suggested that mortality, due mainly to cardiac damage, was reduced or completely absent in patients treated with deferiprone (DFP) alone or a combined deferiprone–deferoxamine (DFP–DFO) chelation treatment. However, no survival analysis has been reported for a long-term randomised control trial. Here, we performed a multicenter, long-term, randomised control trial that compared deferoxamine (DFO) versus DFP alone, sequential DFP–DFO, or combined DFP–DFO iron chelation treatments. The trial included 265 patients with thalassemia major, with 128 (48.3%) females and 137 (51.7%) males. No deaths occurred with the DFP-alone or the combined DFP–DFO treatments. One death occurred due to graft versus host disease (GVHD) in a patient that had undergone bone marrow transplantation; this patient was censored at the time of transplant. Only one death occurred with the DFP–DFO sequential treatment in a patient that had experienced an episode of heart failure one year earlier. Ten deaths occurred with the deferoxamine treatment. The main factors that correlated with an increase in the hazard ratio for death were: cirrhosis, arrhythmia, previous episode of heart failure, diabetes, hypogonadism, and hypothyroidism. In a Cox regression model, the interaction effect of sex and age was statistically significant (p-value<0.013). For each increasing year of age, the hazard ratio for males was 1.03 higher than that for females (p-value<0.013). In conclusion, the results of this study show that the risk factors for predicting mortality in patients with thalassemia major are deferoxamine-treatment, complications, and the interaction effect of sex and age. [Copyright &y& Elsevier]

One hundred eighteen people were killed at Milan''s Linate airport on October 8th, 2001 in a runway collision between a SAS airliner preparing for take-off and a private Cessna plane. The identification of the victims was carried out with visual, anthropological, odontological, and genetic means. The genetic identification was carried out through comparison of the remains with reference samples from personal objects of the victims or blood/saliva samples from their relatives. DNA typing alone led to the identification of 12 victims and 4 body parts, while DNA in combination with odontology allowed to identify 27 victims. The combined work of pathologists, odontologists and geneticists led to the positive identification of all 118 victims in 14 days. [Copyright &y& Elsevier]

Thalassaemia and other haemoglobinopathies constitute an important health problem in Mediterranean countries, placing a tremendous emotional, psychological, and economic burden on their National Health systems. The development of new chelators in the most recent years had a major impact on the treatment of thalassaemia and on the quality of life of thalassaemic patients. A new initiative was promoted by the ItalianMinistry of Health, establishing a Registry for thalassaemic patients to serve as a tool for the development of cost-effective diagnostic and therapeutic approaches and for the definition of guidelines supporting the most appropriate management of the iron-chelating therapy and a correct use of the available iron-chelating agents. This study represents the analysis of the preliminary data collected for the evaluation of current status of the iron chelation practice in the Italian thalassaemic population and describes how therapeutic interventions can widely differ in the different patients' age groups. [ABSTRACT FROM AUTHOR]

Objectives: Previous studies have shown that left ventricular hypertrophy (LVH) represents a cardiovascular risk factor independently of clinic blood pressure (BP). The present study was aimed at determining the impact of LVH on the incidence of cardiovascular morbid and fatal events taking into account not only classical risk factors but also home and ambulatory BP values, which have been shown to have an important independent prognostic impact., Methods: In 1716 patients belonging to the 'Pressioni Arteriose Monitorate E Loro Associazioni' population of Monza, we quantified left ventricular mass index and identified LVH by standard cutoff values. We also measured clinic, home and 24-h ambulatory BPs together with serum glucose and lipids., Results: During a follow-up of 148 months, the rate of fatal and nonfatal (hospitalizations) cardiovascular events as well as of all-cause death was markedly greater (four-fold to five-fold) in patients as compared with those without LVH. In LVH individuals, the increased risk remained significant even when data were adjusted for a large number of other confounding factors including home BP, 24-h mean BP and ambulatory BP. Results were similar when left ventricular mass was indexed by height and body surface area. A 10% increase in left ventricular mass index was associated with a significant increase in cardiovascular risk or all-cause deaths. In multivariate analysis, left ventricular mass index was always an independent predictor of cardiovascular events and death for any cause., Conclusion: Our data provide evidence that LVH is an important risk factor even when the contribution of different BPs to risk is fully taken into account.