1. Long-term study on symptomless human metapneumovirus infection in hematopoietic stem cell transplant recipients.
- Author
-
Debiaggi M, Canducci F, Terulla C, Sampaolo M, Marinozzi MC, Alessandrino PE, Colombo AA, Caldera D, Bragotti LZ, Migliavacca R, Bianchi E, Romero E, and Clementi M
- Subjects
- Acute Disease, Adult, Carrier State, Cross Infection epidemiology, Cross Infection etiology, Humans, Infant, Infant, Newborn, Italy epidemiology, Longitudinal Studies, Metapneumovirus isolation & purification, Nasopharynx virology, Paramyxoviridae Infections etiology, Polymerase Chain Reaction, Prevalence, RNA, Viral genetics, Respiratory Tract Diseases virology, Reverse Transcriptase Polymerase Chain Reaction, Seasons, Sequence Analysis, Hematopoietic Stem Cell Transplantation, Metapneumovirus genetics, Paramyxoviridae Infections epidemiology, Respiratory Tract Diseases epidemiology
- Abstract
From October 2004 through October 2006 a study was performed to evaluate the prevalence of human Metapneumovirus (hMPV) infection in adult hematopoietic stem cell transplant (HSCT) recipients. Sequential nasopharyngeal aspirates (NPA) were collected independently from respiratory symptoms and evaluated for hMPV-RNA by polymerase chain reaction (PCR) and sequence analysis. Results indicate epidemiological and molecular differences between the 2004-2005 and 2005-2006 periods and that hMPV seems not to symptomatically affect HSCT patients or cause late respiratory sequelae. In addition, data collected suggest a hospital origin of hMPV infection in most HSCT patients during the 2004-2005 period.
- Published
- 2007