1. Factors associated with major cardiovascular events in patients with systemic necrotizing vasculitides: results of a longterm followup study.
- Author
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Terrier B, Chironi G, Pagnoux C, Cohen P, Puéchal X, Simon A, Mouthon L, and Guillevin L
- Subjects
- Adult, Aged, Analysis of Variance, Angina, Unstable diagnostic imaging, Angina, Unstable etiology, Angina, Unstable mortality, Atherosclerosis diagnostic imaging, Atherosclerosis mortality, Cardiovascular Diseases diagnostic imaging, Chi-Square Distribution, Cohort Studies, Disease-Free Survival, Female, Follow-Up Studies, Humans, Incidence, Italy, Kaplan-Meier Estimate, Male, Middle Aged, Myocardial Infarction diagnostic imaging, Myocardial Infarction etiology, Myocardial Infarction mortality, Polyarteritis Nodosa complications, Polyarteritis Nodosa drug therapy, Retrospective Studies, Risk Assessment, Severity of Illness Index, Stroke diagnostic imaging, Stroke etiology, Stroke mortality, Survival Rate, Time Factors, Ultrasonography, Doppler methods, Atherosclerosis etiology, Cardiovascular Diseases etiology, Cardiovascular Diseases mortality, Cause of Death, Polyarteritis Nodosa diagnosis
- Abstract
Objective: Systemic necrotizing vasculitides (SNV) are associated with more frequent subclinical atherosclerosis, suggesting that SNV might be associated with a higher risk of major cardiovascular events (MCVE). We aimed to identify factors predictive of MCVE in patients with SNV., Methods: Patients in remission from SNV were assessed for CV risk factors and subclinical atherosclerosis. MCVE was defined as myocardial infarction, stroke, arterial revascularization, hospitalization for unstable angina, and/or death from CV causes. MCVE-free survival curves were compared using the log-rank test., Results: Forty-two patients were followed for 7.1±2.6 years. Eight patients (18.9%) had MCVE. The respective 5- and 10-year MCVE rates were 9.5% and 26.8%. National Cholesterol Education Program/Adult Treatment Panel III (NCEP/ATP III)-defined high-risk status [hazard ratio (HR) 5.02 (95% CI: 1.17-27.4), p=0.03], BMI>30 kg/m2 [HR 4.84 (95% CI: 1.46-116), p=0.02], and plaque detection in the abdominal aorta (p=0.01) were significantly associated with MCVE. SNV characteristics, corticosteroid maintenance therapy, and C-reactive protein>5 mg/l were not associated with MCVE. Plaque in the aorta was significantly associated with high-risk status (p<0.001), while BMI and high-risk status were independent variables. Thus, a BMI>30 kg/m2 and/or a high-risk status were strongly associated with MCVE (p=0.004). Carotid intima-media thickness (IMT) identified patients with early MCVE and was correlated with the time to MCVE (r2=0.68, p=0.01)., Conclusion: These results suggest that factors associated with a higher MCVE risk in patients with SNV are NCEP/ATP III-defined high-risk status and BMI>30 kg/m2. Carotid IMT could help identify patients with SNV at risk of early MCVE.
- Published
- 2014
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