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Two science teaching workshops for students of the elementary teacher education degree course at the University of Palermo, Italy are discussed, one based on inquiry-based methods and the other on "traditional" teaching methods. A questionnaire aimed to understand the teaching styles preferred by students, their reasons for learning/teaching science, and their beliefs about the difficulties a teacher faces when planning and trying out science teaching activities in the class were completed by the students before the first workshop, at its end, and the end of the second workshop. The answers given by the students were studied using cluster analysis methods. The results of the analysis of answers given to initial and intermediate questionnaires indicate that the students recognize the importance of teaching scientific subjects in elementary school. However, the self-perception of their abilities to effectively teach science is negative, both before and after attending the "traditional" type teaching workshop. After doing the inquiry-based teaching workshop and holding several days of a science fair, most of the students' negative beliefs have changed into positive ones. A better general understanding of the fundamental role played by the teacher in encouraging the natural curiosity of children and offering scientific activities based on everyday life experiences was observed.

The problem of taking a data set and separating it into subgroups, where the members of each subgroup are more similar to each other than they are to members outside the subgroup, has been extensively studied in science and mathematics education research. Student responses to written questions and multiple-choice tests have been characterised and studied using several qualitative and/or quantitative analysis methods. However, there are inherent difficulties in the categorisation of student responses in the case of open-ended questionnaires. Very often, researcher bias means that the categories picked out tend to find the groups of students that the researcher is seeking out. In this paper, we discuss an example of application of a quantitative, non-hierarchical analysis method to interpret the answers given by 118 Tenth Grade students in Palermo (Italy), to six open-ended questions about algebraic thinking. We show that the use of non-hierarchical analysis allows us to interpret the reasoning of students solving different mathematical problems using Algebra, and to separate them into different groups, that can be recognised and characterised by common traits in their answers, without any prior knowledge on the part of the researcher of what form those groups would take (unbiased classification).

Two 20-h modelling-based workshops focused on the explanation of thermally activated phenomena were held at the University of Palermo, Italy, during the Academic Year 2014-2015. One of them was conducted by applying an inquiry-based approach, while the other, still based on laboratory and modelling activities, was not focused on inquiry. Seventy-two students belonging to the Undergraduate Program for Chemical Engineering attended the two workshops. The related content was focused on an "à la Feynman" unifying approach to thermally activated phenomena. Questionnaires were administered to the students of both groups, before and post instruction. Responses were analysed using k-means cluster analysis and students' inferred lines of reasoning about the description and explanation of phenomena were studied in both groups. We find that both workshops can be considered effective in improving student's reasoning skills. However, the inquiry-based approach revealed to be more effective than the traditional one in helping students to build mechanisms of functioning and explicative models and to identify common aspects in apparently different phenomena.

The paper presents some reflections and activities developed by researchers and teachers involved in teacher education programs on cultural transposition. The construct of cultural transposition is presented as a condition for decentralizing the didactic practice of a specific cultural context through contact with other didactic practices of different cultural contexts. We discuss the background theoretical issues of this approach and also give an analysis of two examples of cultural transposition experiences carried out in Italy. In particular, by means of qualitative analysis of some excerpts, discussions, and interviews, we show that the contact with different perspectives coming from China and Russia fostered educational practices and reflections on whole number arithmetic education.

A relevant aim of research in education is to find and study the reasoning lines that students deploy when dealing with problematic situations. This can be done through an analysis of the answers students give to a questionnaire. In this paper, we discuss some methodological aspects involved in the quantitative analysis of a questionnaire by means of two different clustering methods, a hierarchical one and a nonhierarchical one. We start from the coding procedures needed to obtain analyzable data from the questionnaire and from a definition of a correlation coefficient suitable for measuring student similarity in the case of binary coding of student answers. Then, criteria to choose the optimal number of clusters are discussed, and for the same purpose a new coefficient is introduced that measures the total amount of information we can obtain from a clustering solution. We show that each cluster can be characterized by its centroid that summarizes the answers most frequently given by the cluster students to the questionnaire. Finally, an example of the application of these procedures to a student sample is given, and a comparison between the two clustering methods is discussed.

Research in Science Education has shown that often students need to learn how to identify differences and similarities between descriptive and explicative models. The development and use of explicative skills in the field of thermal science has always been a difficult objective to reach. A way to develop analogical reasoning is to use in Science Education unifying conceptual frameworks. In this paper we describe a 20-hour workshop focused on Feynman's Unifying Approach and the two-level system. We measure its efficacy in helping undergraduate chemical engineering students explain phenomena by applying an explanatory model. Contexts involve systems for which a process is activated by thermally overcoming a well-defined potential barrier. A questionnaire containing six open-ended questions was administered to the students before instruction. A second one, similar but focused on different physical content was administered after instruction. Responses were analysed using k-means Cluster Analysis and students' inferred lines of reasoning about the analysed phenomena were studied. We conclude that students reasoning lines seem to have clearly evolved to explicative ones and it is reasonable to think that the Feynman Unifying Approach has favoured this change.

Effective site characterization in highly urbanized coastal lowlands requires accurate stratigraphic and geophysical investigations. In these regions, which typically host shallowly buried paleovalley systems formed in response to Quaternary glacio‐eustatic fluctuations, the marked lithologic contrast between soft sediment paleovalley fills and the adjacent, stiff substrate has the potential to modify earthquake motions, and assessment of critical parameters, such as shear wave velocities (VS) and resonance frequencies (f), should be coupled with detailed stratigraphic architecture. To evaluate the potential of the microtremor horizontal‐to‐vertical spectral ratio (mHVSR) for paleovalley recognition and mapping, we performed mHVSR measurements along the Adriatic coastal plain of Italy, where two paleovalley systems (Pescara and Manfredonia) have been recently identified. In both areas, we detected rapid lateral variations in resonance frequencies and highlighted laterally continuous impedance contrasts. Relying on a robust stratigraphic framework, we carefully evaluated the relation between geological and geophysical data and identified the stratigraphic surfaces responsible for the observed resonances. We derived VS models for the sediment fill, reconstructing the geometry of the two buried paleovalleys. We address the importance of evaluating the geological context when designing microzonation studies, for a reliable interpretation of changes in resonance frequencies. Plain Language Summary: When earthquakes occur, buildings shake differently based on several factors, including seismic wave velocity, natural resonance frequencies, and local geological characteristics. Beneath modern coastal lowlands, the presence of paleovalley systems can significantly modify the ground motion. Identification of these buried bodies is therefore essential to assess and reduce seismic hazard. Paleovalleys are shallow incisions formed under periods of fluvial erosion in response to Quaternary climate fluctuations, and subsequently filled with very soft clay. These bodies are found worldwide, and do not have any geomorphological evidence, making their recognition challenging. Geologists typically use expensive sediment core analysis to identify paleovalleys, but this method can only provide spotty information. Geophysical exploration techniques that rely on microtremors (small vibrations on the Earth) can complement mapping of these buried bodies. In this work, we tested this technique in Pescara and Mafredonia (Adriatic coastal plain, Italy), providing dense information about paleovalley geometries and geophysical parameters crucial for predicting how the ground will shake during an earthquake. This study also highlights the importance of integrating disciplines to improve our understanding of subsoil and to design future studies to mitigate seismic hazards. Key Points: Paleovalley fills are key sediment bodies made up of soft clay, tens of m thick and few km wide, buried beneath coastal lowlands worldwideMicrotremor‐based paleovalley profiles and stratigraphic cross‐sections exhibit strong similarityMicrotremor can provide shear wave velocities and resonance frequencies of paleovalleys, key parameters for seismic hazard mitigation [ABSTRACT FROM AUTHOR]

This paper describes a method aimed at pointing out the quality of the mental models undergraduate engineering students deploy when asked to create explanations for phenomena or processes and/or use a given model in the same context. Student responses to a specially designed written questionnaire are quantitatively analyzed using researcher-generated categories of reasoning, based on the physics education research literature on student understanding of the relevant physics content. The use of statistical implicative analysis tools allows us to successfully identify clusters of students with respect to the similarity to the reasoning categories, defined as "practical or everyday," "descriptive," or "explicative." Through the use of similarity and implication indexes our method also enables us to study the consistency in students' deployment of mental models. A qualitative analysis of interviews conducted with students after they had completed the questionnaire is used to clarify some aspects which emerged from the quantitative analysis and validate the results obtained. Some implications of this joint use of quantitative and qualitative analysis for the design of a learning environment focused on the understanding of some aspects of the world at the level of causation and mechanisms of functioning are discussed. (Contains 3 tables, 4 figures, and 7 footnotes.)

Although a large part of Italy is characterized by a Mediterranean climate intrinsically highly suitable for olive cultivation, farmers may experience variable interannual yields with associated agronomic and management costs. A detailed overview of major climate stressors and their ongoing impacts on olive yield variability at a broad spatial–temporal scale across Italy could improve the understanding of how interannual olive yields are modulated by seasonal local climate and would enhance the development of actionable services to alert stakeholders of potential climate risks. We analysed aggregated olive yield data from the Italian National Statistics Institute (ISTAT) at the provincial level during 2006–2020, and several climatic variables from the Reanalysis v5 (ERA5) of the European Centre for Medium‐Range Weather Forecasts (ECMWF) as a basis to (i) explore olive yield trends and inter‐annual variations over the whole country; (ii) identify major seasonal climate stressors likely responsible for the largest variations in yield and (iii) develop a composite index that summarizes the risk of having exceptionally low yields due to the co‐occurrence of multiple stressors. To this end, we defined two extreme classes of yield, namely, exceptionally low and high yields (LY and HY, respectively) and explored the climatic variables aggregated on a bimonthly time scale that influenced yield outcomes. Our analysis showed that exceptional low yields have been erratically increasing since 2014 with temperature‐related variables having the highest impact, especially a relatively warm winter and cool early autumn. These period‐specific variables were major components of the resulting composite index predicting the likelihood of LY ranging from 28% to 49% due to increasing stress effects. Possible explanations of our findings are discussed, including the proliferation of the olive fly. We suggest the composite risk approach could lay the groundwork for an integrated meteorological seasonal forecasting system that provides timely insights on factors affecting within‐season olive yield development. [ABSTRACT FROM AUTHOR]

In this paper we discuss a study on the approaches to modeling of students of the 4-year elementary school teacher program at the University of Palermo, Italy. The answers to a specially designed questionnaire are analyzed on the basis of an "a priori" analysis made using a general scheme of reference on the epistemology of mathematics and physics. The study is performed by using quantitative data analysis methods, i.e. factorial analysis of the correspondences and implicative analysis. A qualitative analysis of key words and terms used by students during interviews is also used to examine some aspects that emerged from the quantitative analysis. The students have been classified on the basis of their different epistemological approaches to knowledge construction, and implications between different conceptual strategies used to answer the questionnaire have been highlighted. The study's conclusions are consistent with previous research, but the use of quantitative data analysis allowed us to classify the students into three "profiles" related to different epistemological approaches to knowledge construction, and to show the implications of the different conceptual strategies used to answer the questionnaire, giving an estimation of the classification or implication "strength." Some hints on how a course for elementary school physics and mathematics education can be planned to orient the future teachers to the construction of models of explanation are reported. (Contains 2 figures, 3 tables, and 8 footnotes.)

Coastal areas are dynamic environments that easily change over time. To contribute to a better understanding of natural and anthropogenic factors that may have contributed in the past and/or control present-day and near-future coastline modifications, we have realised a chronologically arranged sequence of three geomorphological and geothematic maps focusing on the southern Molise coast (Adriatic coast, Italy). The first two maps concern the geomorphological and anthropogenic modifications that occurred respectively from the Holocene to the 1950s (Map 1), and from the 1950s to the Present (Map 2). The third map deals with the present-day conditions and near-future scenarios of coastal hazard considering the period from the Present to the year 2050. Results obtained and comparative observations of the three maps highlight the elevated shoreline mobility of the Biferno River alluvial coastal plain sector, and its high susceptibility to further coastal hazard due to erosion and inundation. [ABSTRACT FROM AUTHOR]

Copyright of SCENARIO: Official Italian Journal of ANIARTI is the property of ANIARTI and its content may not be copied or emailed to multiple sites or posted to a listserv without the copyright holder's express written permission. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract. (Copyright applies to all Abstracts.)

In Italy, approximately 400.000 new cases of malignant tumors are recorded every year. The average of annual deaths caused by tumors, according to the Italian Cancer Registers, is about 3.5 deaths and about 2.5 per 1,000 men and women respectively, for a total of about 3 deaths every 1,000 people. Long-term (at least a decade) and spatially detailed data (up to the municipality scale) are neither easily accessible nor fully available for public consultation by the citizens, scientists, research groups, and associations. Therefore, here we present a ten-year (2009–2018) database on cancer mortality rates (in the form of Standardized Mortality Ratios, SMR) for 23 cancer macro-types in Italy on municipal, provincial, and regional scales. We aim to make easily accessible a comprehensive, ready-to-use, and openly accessible source of data on the most updated status of cancer mortality in Italy for local and national stakeholders, researchers, and policymakers and to provide researchers with ready-to-use data to perform specific studies. Measurement(s) Standardized Mortality Ratio Technology Type(s) Public database [ABSTRACT FROM AUTHOR]

Coastal erosion and its impacts on the involved communities is a topic of great scientific interest that also reflects the need for modern as well as cost and time-effective methodologies to be integrated into or even to substitute traditional investigation methods. The present study is based on an integrated approach that involves the use of data derived from UAV (Unmanned Aerial Vehicle) surveys. The study illustrates the long- to short-term shoreline evolution of the Molise coast (southern Italy) and then focuses on two selected beach stretches (Petacciato and Campomarino beaches), for which annual UAV surveys were performed from 2019 to 2021, to assess their most recent shoreline and morpho-topographical changes and related effects on their coastal vulnerability. UAV data were processed using the Structure from Motion (SfM) image processing tool. Along the beach profiles derived from the produced DEMs, the coastal vulnerability of the selected beach stretches was evaluated by using the Coastal Vulnerability Assessment (CVA) approach. The results obtained highlight some significant worsening of CVA indexes from 2019 to 2021, especially for the Campomarino beach, confirming the importance of the periodic updating of previous data. In conclusion, the easy use of the UAV technology and the good quality of the derived data make it an excellent approach for integration into traditional methodologies for the assessment of short-term shoreline and beach changes as well as for monitoring coastal vulnerability. [ABSTRACT FROM AUTHOR]

Background: The aim of this study was to investigate how the COVID-19 pandemic influenced ERAS program application in colorectal surgery across hospitals in the Lazio region (central district in Italy) participating in the "Lazio Network" project. Methods: A multi-institutional database was constructed. All patients included in this study underwent elective colorectal surgery for both malignant and benign disease between January 2019 and December 2020. Emergency procedures were excluded. The population was divided into 2 groups: a pre-COVID-19 group (PG) of patients operated on between February and December 2019 and a COVID-19 group (CG) of patients operated on between February and December 2020, during the first 2 waves of the pandemic in Italy. Results: The groups included 622 patients in the PG and 615 in the CG treated in 8 hospitals of the network. The mean number of items applied was higher in the PG (65.6% vs. 56.6%, p < 0.001) in terms of preoperative items (64.2% vs. 50.7%, p < 0.001), intraoperative items (65.0% vs. 53.3%, p < 0.001), and postoperative items (68.8% vs. 63.2%, p < 0.001). Postoperative recovery was faster in the PG, with a shorter time to first flatus, first stool, autonomous mobilization and discharge (6.82 days vs. 7.43 days, p = 0.021). Postoperative complications, mortality and reoperations were similar among the groups. Conclusions: The COVID-19 pandemic had a negative impact on the application of ERAS in the centers of the "Lazio Network" study group, with a reduction in adherence to the ERAS protocol in terms of preoperative, intraoperative and postoperative items. In addition, in the CG, the patients had worse postoperative outcomes with respect to recovery and discharge. [ABSTRACT FROM AUTHOR]

The map is aimed at illustrating the relationships between landscape evolution and human occupation in the Isernia basin since the Middle Pleistocene. We carried out a detail scale geological–geomorphological investigation integrated with archaeological data. Overall data suggest enhanced landscape modification related to the long-term evolution of the Isernia basin. Moreover, during the Middle Pleistocene an alluvial plain environment was present, as testified also by the famous Lower Palaeolithic site of Isernia La Pineta dated to ca. 600 ky. From 600 ky onwards, extensional tectonics and related valley incision reshaped the Isernia basin, with the formation of terraced surfaces and the deposition of a travertine plateau. Archaeological findings from the Lower Palaeolithic up to the Chalcolithic Age testify to pre- and protohistoric settlements on these surfaces. In historical times, Romans settled on the Isernia terrace ridge taking advantage of the outcropping travertines to support wall foundations and to extract construction material. [ABSTRACT FROM AUTHOR]

Sea-level rise as a consequence of global warming increases the need to analyze coastal risks to conceive adaptation strategies aimed at coping with marine impacts at both short- and long-term scales. In this context, this study presents future scenarios of inundation risk evaluated along the main alluvial coastal plains of the Campania region (Italy). Due to their geomorphological and stratigraphical setting, the investigated areas are characterized by low topography and relevant but variable subsidence rates. Based on the upgrade of already published data and the new analysis of available datasets derived by multi-temporal interferometric processing of satellite Synthetic Aperture Radar (SAR) images, future scenarios of local sea level for the years 2065 and 2100 have been evaluated coupling global projections with local subsidence trends. Furthermore, aspects related with the distribution of natural and anthropic assets, as well as the local social vulnerability, have been taken into account to calculate the overall risk. The inundation risk maps here proposed can effectively address the request to improve the knowledge of policymakers and local administrators and to raise their awareness about the potential impacts of climate change in coastal areas. [ABSTRACT FROM AUTHOR]

Summary: Earth's microbial biosphere extends down through the crust and much of the subsurface, including those microbial ecosystems located within cave systems. Here, we elucidate the microbial ecosystems within anthropogenic 'caves'; the Iron‐Age, subterranean tombs of central Italy. The interior walls of the rock (calcium‐rich macco) were painted ~2500 years ago and are covered with CaCO3 needles (known as moonmilk). The aims of the current study were to: identify biological/geochemical/biophysical determinants of and characterize bacterial communities involved in CaCO3 precipitation; challenge the maxim that biogenic activity necessarily degrades surfaces; locate the bacterial cells that are the source of the CaCO3 precipitate; and gain insight into the kinetics of moonmilk formation. We reveal that this environment hosts communities that consist primarily of bacteria that are mesophilic for temperature and xerotolerance (including Actinobacteria, Bacteroidetes and Proteobacteria); is populated by photosynthetic Cyanobacteria exhibiting heterotrophic nutrition (Calothrix and Chroococcidiopsis); and has CaCO3 precipitating on the rock surfaces (confirmation that this process is biogenic) that acts to preserve rather than damage the painted surface. We also identified that some community members are psychrotolerant (Polaromonas), acidotolerant or acidophilic (members of the Acidobacteria), or resistant to ionizing radiation (Brevundimonas and Truepera); elucidate the ways in which microbiology impacts mineralogy and vice versa; and reveal that biogenic formation of moonmilk can occur rapidly, that is, over a period of 10 to 56 years. We discuss the paradox that these ecosystems, that are for the most part in the dark and lack primary production, are apparently highly active, biodiverse and biomass‐rich. [ABSTRACT FROM AUTHOR]

Illegal driftnetting causes each year several entanglements and deaths of sperm whales in different Mediterranean areas, primarily in the Tyrrhenian Sea. In summer 2020, during the June-July fishing season, two sperm whales were found entangled in illegal driftnets in the Aeolian Archipelago waters, Southern Italy. These two rare events were an exceptional chance to collect behavioural and acoustics data about entangled sperm whales. We analysed 1132 one-minute sets of breathing/behavioural data and 1575 minutes of acoustic recording, when the whales were found entangled, during the rescue operation, immediately after release, and in the days thereafter. The first whale was generally quiet showing a general status of debilitation/weakness, numerous skin lesions, and low breathing rate (0.31 (0.60)); it collaborated during rescue operations. On the contrary, the second whale showed a high level of agitation with a high breathing rate (1.48 (1.31)) during both the entanglement period and the net cutting operations, vigorously moving its fluke and pectoral fins, opening its mouth, sideway rolling or side fluking and frequently defecating. Acoustically, the first whale produced mainly single clicks in all phases except for two series of creaks during rescuing operations while the second whale produced a wide range of vocalizations (single clicks, likely either slow clicks or regular clicks, creaks, and codas). Our observations indicate that acoustics, respiratory and behavioural parameters may be useful to monitor the physical/physiological status of sperm whales during disentanglement operations. [ABSTRACT FROM AUTHOR]

Copyright of SCENARIO: Official Italian Journal of ANIARTI is the property of ANIARTI and its content may not be copied or emailed to multiple sites or posted to a listserv without the copyright holder's express written permission. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract. (Copyright applies to all Abstracts.)

Inflammatory bowel diseases (IBDs) are a public health issue with over 3.5 million patients in Europe, but the advent of several biologic agents has completely changed their management. Pharmacovigilance is needed to early detect expected/unexpected adverse events (AEs) to assess the safety of drugs in a real-world setting. Aim of this prospective pharmacovigilance study was to evaluate the occurrence of AEs in patients treated with biologic drugs in gastroenterology units in Southern Italy. All consecutive patients treated with one biologic drug during a 2-years period (2017–2018) in six gastroenterology tertiary units and satisfying inclusion criteria were enrolled. Demographic and clinical characteristics of patients, type of treatment used, therapy discontinuation, failures, switch/swap to another biologic, and possible onset of AEs were collected. Adverse events have been compared to the number of AEs reported in the same centres in the two years before the protocol. Overall, 623 patients (253 females) with Crohn's disease (352; 56.5%) or ulcerative colitis (271; 43.5%) have been included. Infliximab (IFX) was the most commonly used (308, 49.4%), followed by adalimumab (ADA; 215, 34.5%), vedolizumab (VED; 73, 11.7%), golimumab (GOL; 26, 4.2%) and ustekinumab (UST; 0.2%). Ninety-two patients have experienced AEs (14.8%) and 10 serious adverse events (SAEs) (1.6%) were recorded. Adverse events and SAEs have been reported with GOL (7/26; p =.88), IFX (51/308; p =.54), ADA (28/125; p =.40) and VED (6/73; p =.11), no AEs occurred with UST (0/1). Overall, considering the low rate of AEs reported and discontinuation from therapy, our data seems to confirm the positive beneficial/risk ratio of biologic treatment for IBDs and provide useful data on biologic drugs in gastroenterology. [ABSTRACT FROM AUTHOR]

Interdisciplinary studies of the last years highlight that the Italian coasts are significantly subject to retreat and to inundation by sea ingression due to natural and anthropic causes. In this study, the effects of future relative sea level have been evaluated for the Volturno River Plain, one of the widest coastal plain in southern Italy. The plain is characterized by high economical and ecological value, for the presence of farm activities, tourist structures and wetland protected zones. The study area is potentially prone to coastal flooding due to its very low topography and because it is affected by a severe subsidence, which emphasize the local effect of sea level rise due to the ongoing climate changes. In accordance with the guidelines of the MEDFLOOD project, the areas prone to inundation in the years 2065 and 2100 have been evaluated by comparing the future topographical information and expected relative sea level scenarios. The local Vertical Ground Displacements have been derived by PS-InSAR processing data whilst the mean values of the scenarios RCP 2.6 and RCP 8.5 provided by the IPCC (2014) have been used as future sea level projections in 2065 and 2100. The PS-InSar data elaboration shows that the area affected by subsidence corresponds to 35% of the Volturno plain and that the annual rate of the phenomenon ranges between −1 and −25 mm/yr. The inundation analysis, based on the classification of the areas in four hazard classes, indicates that in 2065 the zones located below the sea level will increase approximately of 50% respect to the present conditions, while between 2065 and 2100 the increase can be at least of 60% (IPCC, RCP 8.5 scenarios). Considering the socio-economical and ecological exposure, evaluated following the EUROSION project guidelines, the coastal flooding risk maps have been produced. Almost 8.2 km 2 and 14.4 km 2 of the investigated area has to be considered subject to very high marine inundation risk in 2065 and 2100, respectively. [ABSTRACT FROM AUTHOR]

This article engages with questions of the integration of different scales of analysis in the study of labour and radical movements: ‘transnational’, ‘national’ and ‘local’ or ‘trans-local’. The article places the study of transnational anarchism in a ‘national’ and ‘trans-local’ perspective. The analysis of the intersection between the networks of those who migrated from Italy and those who remained provides a fruitful means to uncover dynamics within the transnational anarchist movement and the interplay, in both directions, between home country, exile communities and host countries. The article focuses on the crucial, but still unexplored, contributions of communities of Italian anarchists abroad (in, among other places, London, Paris, Berne, Marseille, Barre and Buenos Aires) to the anti-militarist campaigns against the Italian colonial enterprise in Libya from 1911 to 1914, in terms of propaganda, theoretical debate, financing and countercultural production. The investigation of the initiatives of anarchist exiles and how they coordinated with their comrades in Italy provides a significant case study, not only to understand network-based transnational anarchism but also to reflect on mechanisms of political migration and their influence on the development of social conflicts. [ABSTRACT FROM PUBLISHER]

The calibration of a reliable phenological model for olive grown in areas characterized by great environmental heterogeneity, like Italy, where many varieties exist, is challenging and often suffers from a lack of observations, especially on budbreak. In this study, we used a database encompassing many phenological events from different olive varieties, years, and sites scattered all over Italy to identify the phases in which site-enlarged developmental rates can be well regressed against air temperature (Developmental Rate function, DR) by testing both linear and nonlinear functions. A K-fold cross-validation (KfCV) was carried out to evaluate the ability of DR functions to predict phenological development. The cross-validation showed that the phases ranging from budbreak (BBCH 01 and 07) to flowering (BBCH 61 and 65) and from the beginning of flowering (BBCH 51) to flowering can be simulated with high accuracy (r2 = 0.93–0.96; RMSE = 3.9–6.6 days) with no appreciable difference among linear and nonlinear functions. Thus, the resulting DRs represent a simple yet reliable tool for regional phenological simulations for these phases in Italy, paving the way for a reverse modeling approach aimed at reconstructing the budbreak dates. By contrast, and despite a large number of phases explored, no appreciable results were obtained on other phases, suggesting possible interplays of different drivers that need to be further investigated. [ABSTRACT FROM AUTHOR]

This paper presents a new method for coastal vulnerability assessment (CVA), which relies upon three indicators: run-up distance (as a measurement of coastal inundation), beach retreat (as a measurement of potential erosion), and beach erosion rate (obtained through the shoreline positions in different periods). The coastal vulnerability analysis of Sele Coastal Plain to storm impacts is examined along a number of beach profiles realized between 2008 and 2009. This particular study area has been selected due to its low-lying topography and high erosion propensity. Results are given in terms of an impact index, performed by combining the response due to coastal inundation, storm erosion, and beach erosion rate. This analysis is implemented on the basis of morphosedimentary characteristics of the beach, wave climate evaluation, and examination of multitemporal aerial photographs and topographic maps. The analysis of the final results evidences different coastal responses as a function of the beach width and slope, which in turn depend on the local anthropization level. The comparison of this method with a Coastal Vulnerability Index method evidences the better attitude of CVA index to take into account the different beach features to explain the experienced damages in specific stretches of the coastline considered. [ABSTRACT FROM AUTHOR]

A 1:28,000 scale geomorphological map of the central sector of the Matese Mountains (Southern Italy) is presented in this paper. Geomorphological investigation by means of remote sensing, cartographic analysis and field surveys allowed the identification of the main geomorphic processes and to map the related landforms which are both of monogenetic and polygenetic origin. Most of them are erosional landforms generated by the action of periglacial, glacial and karst processes which often occur under the control of the geological structure. Glacial relics and polygenetic landforms of glaciokarst and fluviokarst origin provide good evidence of the strong influence of variable climatic conditions on landform genesis during the Quaternary. They also highlight the influence of extensive tectonics during the Quaternary which caused progressive uplift, fragmentation and disarticulation of the developing mountainous landscape and its consequent polycyclic evolution. The map illustrates the geomorphologic peculiarities of the Mediterranean mountain landscape that typically characterizes the Apennine chain, and contributes to the understanding of its tectonic evolution and the influence of climate and climatic changes on landscape evolution. It further provides a basic map for land planning policy including the exploitation of the geological heritage and the development of sustainable mountain tourism and geo-tourism. [ABSTRACT FROM AUTHOR]

In the Mediterranean, the coastal population was estimated at 146 million in 1990 and the urban coastal population alone is projected to rise to 176 million by 2025, with an addition of 350 million of tourists per year. In coastal zones, forecasting shoreline location and changes in time is a basic tool for decisional making regarding land management and future planning. Historical maps, aerial photography, topographic maps and a beach survey were used as data sources to detect the shorelines of the Sele Plain coastline between the towns of Salerno and Agropoli (southern Italy) and define its change from 1870 to 2009. By using the potential of ArcGIS release 8.3 software and its extension digital shoreline analysis system, we followed two main stages. The first required identification of the shorelines, reducing to a minimum the errors associated to the suitability of source material, distortion of the photographs, residuals in georeferencing, and seasonal shoreline variation. The second was to define the shoreline variations along 170 transects spaced every 200 m. This systematic analysis showed that in the Sele River plain the highest rates of erosion, generally localized at river mouths (Picentino River, mean value = 0.4 m/y; Sele River, mean value = 1.3 m/y), have decreased in the last 20 years, revealing that the beach system is acquiring new coastal stability. [ABSTRACT FROM AUTHOR]

A 1:50,000-scale geomorphological map of the area between the settlements of Frosolone and Trivento (Molise Region, Italy) is presented and discussed in this paper. Field surveys and air photo interpretations allowed the characterization of the main morphological landforms of the study area, drawn from the reduction of an original 1:5,000-scale field map. The landforms have been grouped on the basis of the main controlling factors, as follows: i) tectonic and structural landforms; ii) slope landforms; iii) karst landforms; iv) fluvial landforms. This map shows the distribution of the geomorphic processes presently active, as well as the main relic landforms. Consequently, the collected data aim to provide a useful and easy tool for land planning policy; in addition, since the study area represents a typical geomorphic scenario of the southern Apennines, the data produced could be used in developing more widely-applicable landscape evolution models. [ABSTRACT FROM AUTHOR]

A total of 507,671 people ≥65 experienced hip fractures between 2000 and 2005. In 2005, 94,471 people ≥65 were hospitalized due to hip fractures, corresponding to a 28.5% increase over 6 years. Most fractures occurred in patients ≥75 (82.9%; n = 420,890; +16% across 6 years), particularly in women (78.2%; n = 396,967). We aimed to analyze incidence and costs of hip fractures in Italy over the last 6 years. We analyzed the national hospitalization and DRG databases concerning fractures occurred in people ≥65 between 2000 and 2005. A total of 507,671 people ≥65 experienced hip fractures across 6 years, resulting in about 120,000 deaths. In year 2005 94,471 people aged ≥65 were hospitalized due to hip fractures, corresponding to a 28.5% increase over 6 years. The majority of hip fractures occurred in patients ≥75 (82.9%; n = 420,890; +16% across 6 years) and particularly in women (78.2%; n = 396,967). Among women, 84.2% of fractures ( n = 334,223; +28.0% over 6 years) were experienced by patients ≥75, which is known to be the age group with the highest prevalence of osteoporosis, accounting for 68.6% of the overall observed increase in the total number of fractures. Hip fractures in men ≥75 increased by 33.1% (up to 16,540). Hospitalization costs increased across the six examined years (+36.1%) reaching 467 million euros in 2005, while rehabilitation costs rose up to 531 million in the same year. Hip fractures of the elderly are increasing and represent a major health problem in industrialized countries such as Italy. [ABSTRACT FROM AUTHOR]

This paper illustrates the differences in the ordinary commercial distribution of retail outlets and the politically inspired distribution of post offices in Italy and the United States. It compares the distribution of bank branches to the distribution of post offices in Italy and the distribution of retail pharmacies to the distribution of post offices in the U.S. It provides the historical reasons for the disproportionate number of rural post offices in both countries. It also comments on the burden of financing retail postal counters in a competitive environment and on some ways to approach the issue. [ABSTRACT FROM AUTHOR]

Background: Bile duct injuries (BDIs) during laparoscopic cholecystectomy (LC) still are reported with greater frequency than during open cholecystectomy (OC).Methods: In 1999, a retrospective study evaluating the incidence of BDIs during LC in the area of Rome from 1994 to 1998 (group A) was performed. In addition, a prospective audit was started, ending in December 2001 (group B).Results: In group A, 6,419 LCs were performed (222 were converted to OC; 3.4%). In group B, 7,299 LCs were performed (225 were converted to OC; 3.1%). Seventeen BDIs (0.26%) occurred in group A and 16 (0.22%) in group B. Overall, mortality and major morbidity rates were 12.1% and 30.3%, respectively, without significant differences between the two groups.Conclusions: The incidence and clinical relevance of BDIs during LC in the area of Rome appeared to be stable over the past 8 years and were not influenced by the use of a prospective audit, as compared with a retrospective survey. [ABSTRACT FROM AUTHOR]

Insulin resistance is believed to be under the control of several genes often interacting each other. However, whether genetic epistasis does in fact modulate human insulin sensitivity is unknown. In 338 healthy unrelated subjects from Sicily, all nondiabetic and not morbidly obese, we investigated whether two gene polymorphisms previously associated with insulin resistance (namely PC-1 K121Q and PPARγ2 P12A) affect insulin sensitivity by interacting. PC-1 X121Q subjects showed higher level of fasting glucose, lower insulin sensitivity (by both the Matsuda insulin sensitivity index and M values at clamp, the latter performed in a subgroup of 113 subjects representative of the overall cohort) and higher insulin levels during the oral glucose tolerance test (OGTT) than PC-1 K121K subjects. In contrast, no difference in any of the measured variables was observed between PPARγ2 P12P and X12A individuals. The deleterious effect of the PC-1 X121Q genotype on each of these three variables was significant and entirely dependent upon the coexistence of the PPARγ2 P12P genotype. Among PPARγ2 P12P carriers also fasting insulin and glucose levels during OGTT were higher in PC-1 X121Q than in K121K individuals. In contrast, no deleterious effect of the PC-1 X121Q genotype was observed among PPARγ2 X12A carriers; rather, in these subjects a lower body mass index and consequently lower fasting insulin level was observed in PC-1 X121Q than in K121K carriers. Overall, a significant interaction between the two genes was observed on body mass index, insulin levels (both fasting and after OGTT) and both insulin sensitivity (i.e., insulin sensitivity index and M value) and insulin secretion (i.e., HOMA-B%) indexes. [ABSTRACT FROM AUTHOR]

Glycoprotein PC-1 inhibits insulin signaling and, when overexpressed, plays a role in human insulin resistance. Mechanisms of PC-1 overexpression are unknown. We have identified a haplotype in the 3'-untranslated region of the PC-1 gene that may modulate PC-1 expression and confer an increased risk for insulin resistance. Individuals from Sicily, Italy, carrying the "P" haplotype (i.e., a cluster of three single nucleotide polymorphisms: G2897A, G2906C, and C2948T) were at higher risk (P < 0.01) for insulin resistance and had higher (P < 0.05) levels of plasma glucose and insulin during an oral glucose tolerance test and higher levels of cholesterol, HDL cholesterol, and systolic blood pressure. They also had higher (P < 0.05-0.01) PC-1 protein content in both skeletal muscle and cultured skin fibroblasts. In CHO cells transfected with either P or wild-type cDNA, specific PC-1 mRNA half-life was increased for those transfected with P (t/2 = 3.73 +/- 1.0 vs. 1.57 +/- 0.2 h; P < 0.01). In a population of different ethnicity (Gargano, East Coast Italy), patients with type 2 diabetes (the most likely clinical outcome of insulin resistance) had a higher P haplotype frequency than healthy control subjects (7.8 vs. 1.5%, P < 0.01), thus replicating the association between the P allele and the insulin resistance-related abnormalities observed among Sicilians. In conclusion, we have identified a possible molecular mechanism for PC-1 overexpression that confers an increased risk for insulin resistance-related abnormalities. [ABSTRACT FROM AUTHOR]

A mid-term analysis of shoreline evolution was carried out in the present paper for the Trigno river mouth area (5.2 km), located in the northern part of the Molise coast region (southeast Italy). The littoral drift rose (LDR) concept was employed, coupled to the GENESIS one-line model, to produce numerical simulations. The LDR graph was used to define a single, time-invariant, "equivalent wave" component (EW), which was supposed to entirely rule the shoreline changes. Given the inherent bimodality affecting the Molise wave climate, EW could result not significant in forecasting shoreline evolution, since both a climate inversion and a time-varying diffusion extra effect are expected. These aspects, never investigated in the literature, are deepened in the present paper, with the main aims of firstly assessing the explanatory power of the LDR equivalent wave and its significance within a bimodal climate, and secondly checking the role of a time-varying diffusivity. Results confirmed the reliability of the EW concept, even within a bimodal climate. Moreover, the possible effect of a time-varying diffusion, which is expected with a large directional variability, produced insignificant results with respect to the EW. [ABSTRACT FROM AUTHOR]

For crenulate-shaped bays, the coastal outline assumes a specific shape related to the predominant waves in the area: it generally consists of a tangential zone downcoast and a curved portion upcoast. Many coastal engineers have attempted to derive an expression of the headland bay shapes that emerge when a full equilibrium is reached (stable or dynamic). However, even though models for static equilibrium bays exist, they are merely of an empirical kind, lacking further insight on relationships between incident wave characteristics and beach shape. In addition, it is commonly believed that shoreline profiles tend to follow wave fronts, but this has been never fully verified. In this paper, we investigate a possible correlation between static equilibrium profiles and wave front shapes. Numerical experiments have been performed using the MIKE 21 Boussinesq Wave module, and the generated wave fronts have been compared to the hyperbolic-tangent equilibrium profile. A thoughtful analysis of results revealed that a single-headland equilibrium profile is merely the wave front translated perpendicularly to the wave direction at the headland tip, without any influence of wave period or in wave direction. A new function called the "wave-front-bay-shape equation" has been obtained, and the application and validation of this formula to the case-study bay of the Bagnoli coast (south-west of Italy) is described in the paper. [ABSTRACT FROM AUTHOR]

The Molise region (southern Italy) fronts the Adriatic Sea for nearly 36 km and has been suffering from erosion since the mid-20th century. In this article, an in-depth analysis has been conducted in the time-frame 2004–2016, with the purpose of discussing the most recent shoreline evolution trends and individuating the climate forcings that best correlate with them. The results of the study show that an intense erosion process took place between 2011 and 2016, both at the northern and southern parts of the coast. This shoreline retreat is at a large extent a downdrift effect of hard protection systems. Both the direct observation of the coast and numerical simulations, performed with the software GENESIS, indicate that the shoreline response is significantly influenced by wave attacks from approximately 10° N; however, the bimodality that characterizes the Molise coast wave climate may have played an important role in the beach dynamics, especially where structural systems alternate to unprotected shore segments. [ABSTRACT FROM AUTHOR]

Geotourism represents a powerful and new form of sustainable tourism that has rapidly expanded worldwide over the last decades. To promote it, the use of digital and geomatic tools is becoming of increasing importance. Especially mobile information represents one of the most efficient and smart ways to bring geotourism closer to a wide audience. This applies in particular to rural and inner areas, where the exploitation of geoheritage can represent a crucial resource for eco-friendly and sustainable tourism development. With the aim to promote geotourism on a regional scale, we have implemented a mobile devise application for Molise region, tested in the Alto Molise area. This application, called MoGeo App, aims at providing diversified geotourism information that combines geologic attractions (geosites and geologic itineraries) with other possible tourist attractions (other sites of natural and cultural interest), to respond to differentiated interests and needs of a wide audience. Besides geotourism purposes, the structure of MoGeo App can be used also for other purposes such as educational targets, by adapting contents and language. It appears to be a flexible, easily updatable digital tool, adaptable to various target groups, as well as other regional contexts, both inside and outside of Italy. [ABSTRACT FROM AUTHOR]

This paper presents the results of the geological and geomorphological investigation carried out during the first level seismic microzonation project in the Isernia Province territory. The study area falls in one of the most seismically active areas of the Apennine chain and it has been struck, in historical times, by destructive earthquakes that caused several causalities and diffuse damages to the buildings. The analysis points out the occurrence of geological features that can determine possible site amplification phenomena related to areas with extensive outcrops of thick continental deposits or to unstable areas (both covering about 48% of the investigated areas). The latter are sometimes combined with geomorphological features such as scarps, isolated peaks, and ridges that are also responsible for possible site amplification. In addition, a susceptibility to local seismic amplification index has been introduced which highlights that more than 64% of the investigated area, along with a significant percentage of buildings, fall within the highest categories of susceptibility to local seismic amplification. [ABSTRACT FROM AUTHOR]

Objective: To externally validate a nomogram based on ovarian reserve markers as a tool to optimize the FSH starting dose in IVF/ICSI cycles.Study Design: A two-centres retrospective study including 398 infertile women undergoing their first IVF/ICSI cycle (June 2013-June 2014). IVF data were retrieved from two independent IVF centres in Italy (San Raffaele Hospital, Centre 1; Verona Hospital, Centre 2). A central lab for the routine measurement of AMH and FSH was used for both centres. All women were treated based on physical and hormonal characteristics according to locally adopted protocols. The nomogram was then retrospectively applied to the patients comparing the calculated starting dose to the one actually given.Results: In Centre 1, 64/131 women (48.8%) had an ovarian response below the target. While 45 of these patients were treated with a maximal FSH starting dose (≥225 IU), n=19/131 (14.5%) were treated with a submaximal dose. The vast majority of them (n=17/19) would have received a higher FSH starting dose by using the nomogram. Seventeen patients (n=17/131) had hyper response and about half of them would have been treated with a reduced FSH starting dose according to the nomogram. In Centre 2, 142/267 patients (53.2%) had an ovarian response below the target. While 136 of these were treated with a maximal FSH starting dose (≥225 IU), n=6/267 were treated with a submaximal dose. The majority of them (n=5/6) would have received a higher FSH starting dose. Thirty-two (n=32/267) patients had hyper response and more than half of them would have been treated with a reduced FSH dose.Conclusion: In both Centres, applying the nomogram would have resulted in more appropriate FSH starting doses compared to the the ones actually given based on clinicians choices. The use of an objective algorithm based on patient's age, serum FSH and AMH levels may thus be an effective advice on the selection of the tailored FSH starting dose. Hence, the use of this easily available nomogram could increase the proportion of patients achieving the optimal ovarian response. [ABSTRACT FROM AUTHOR]

The increasing reports of Aelurostrongylus abstrusus infection and the new information on Troglostrongylus brevior have spurred the interest of the scientific community towards the research of pharmaceutical compounds effective against both pathogens. A novel topical combination of fipronil, ( S )-methoprene, eprinomectin and praziquantel (Broadline ® , Merial) has been released for the treatment of a variety of feline parasitic infections. The present study reports the efficacy of this spot-on in treating cats naturally infected by feline lungworms. Client owned cats ( n = 191) were enrolled from three geographical areas of Italy and faecal samples were examined by floatation and Baermann techniques. Twenty-three individuals were positive for L1 of A. abstrusus ( n = 18) or T. brevior ( n = 3) or for both species ( n = 2) and they were topically treated with Broadline ® . Seventeen of them were also concomitantly infected by other parasites. Four weeks after treatment, faecal samples were collected and examined to assess the efficacy of a single administration of the product. Based on lungworm larvae counts, the efficacy of the treatment was 90.5% or 100% for A. abstrusus or T. brevior , respectively. Cats released significantly lower amounts of lungworm larvae after treatment compared to pre-treatment ( p < 0.0001). All but three cats were negative for other nematodes after treatment and all cats recovered from respiratory signs. Results of this study indicate that a single administration of the topical combination fipronil, ( S )-methoprene, eprinomectin and praziquantel is effective and safe for the treatment of A. abstrusus and/or T. brevior infections in cats living under field conditions. [ABSTRACT FROM AUTHOR]

Abstract: We examined the role of sexual gender, age, working status, education, cigarettes per day, Fagerström test, age of onset, pharmacologic intervention (bupropion or varenicline), 10 sessions of cognitive–behavioral group counseling therapy (GCT) conducted over 6weeks, and level of attendance of the counseling program as predictors of smoking cessation on 1282 Italian adult smokers. Results of a multi-variate forward stepwise conditional logistic analysis, at the first step, indicate that subjects who attended the program from 4 to 6 sessions and from 1 to 3 sessions, respectively, resulted about 3 times and 24 times more likely to smoke than those attending from 7 to 10 sessions; at the second step, subjects with high Fagerström score were 2 times more likely to smoke than subjects with low/middle Fagerström; at the third step, subjects treated only with GCT were 2 times more likely to smoke than subjects with combined pharmacologic interventions and GCT; at the fourth step, subjects with age of onset less than 17years were 1.5 times more likely to smoke than subjects with a higher age of onset; eventually, at the fifth step women resulted 1.5 times more likely to smoke than men. In conclusion, we found that a steady attendance of the cognitive behavioral program, as well as the addition of pharmacologic interventions to counseling, remarkably increased the probability of the smoking cessation behavior to be determined. Nevertheless, FTQ was a valid measure in predicting the smoking cessation, and women revealed to be more likely to keep the smoking behavior, as well as subjects who declared an age of onset less than 17years. [Copyright &y& Elsevier]

Many coastlines around the world are subsiding, often due to tectonic causes. In tectonically active areas, the exploitation of natural resources has caused acceleration of subsidence rates. In these cases, it is difficult to separate the many different components of the subsidence process. We try to fill this gap, using both remote sensing data and geological evidence, in an area located in southern Italy (Sele River plain) and characterized by the presence of both human activities and natural processes. The coastal sector of the Sele plain shows a complex subsidence pattern, as testified by Persistent Scatterer Interferometry (PS InSAR) data related to a period of about two decades (1992–2010), that we put in correlation with stratigraphical data from both outcrops and boreholes (ca. 250). The Quaternary infill of the coastal sectors of the plain is not laterally isotropic and homogeneous because of the presence of layers of clastic sediments with different degrees of compaction. Dunal and beach sands, back-ridge (lagoonal and palustrine) silty clays, palaeosols and thick peaty layers are the main facies of this sedimentary prism. The back-ridge depressions hosted palustrine and marshy environments and were artificially drained in the last centuries. The main output of the PS- InSAR analysis is a map of vertical ground deformation (VGD), which has been a useful tool to understand the causes of the subsidence process if combined with geological data from field and boreholes. In fact, the overlay of the SAR interferometry VGD map with the geomorphological and stratigraphical features shows that the subsidence is higher in the northern sector of the plain, where the Quaternary alluvial-coastal deposits are thicker because of the structural asymmetry of the graben. The maximum subsidence rate, however, can be observed in the central part of the plain, in correspondence of the Sele, Tusciano and Picentino river mouths and in the coastal belt. This could be related to the thickness of loose sediments (>20 m) and to the presence of still compacting clay-rich sediments. In the southernmost sector the rates are the lowest recorded in the plain due to the minor thickness of Holocene deposits and to the presence of very thick sedimentary bodies of travertine. The understanding of subsidence patterns may represent a basic tool for future studies about the assessment of the coastal inundation hazard and related risk mitigation in the Sele River plain. Such a tool may reinforce the methodological approach to risk assessment in similar morphological settings. • Study of the subsidence pattern from the Sele River coastal plain, southern Italy • Subsidence map obtained combining two decades of InSAR and geological-geomorphic data. • Land-use data were taken into account to better define the role of anthropogenic impact. • Multidisciplinary approach to understand the causes of subsidence in coastal plains [ABSTRACT FROM AUTHOR]

Tumours are nowadays the second world‑leading cause of death after cardiovascular diseases. During the last decades of cancer research, lifestyle and random/genetic factors have been blamed for cancer mortality, with obesity, sedentary habits, alcoholism, and smoking contributing as supposed major causes. However, there is an emerging consensus that environmental pollution should be considered one of the main triggers. Unfortunately, all this preliminary scientific evidence has not always been followed by governments and institutions, which still fail to pursue research on cancer's environmental connections. In this unprecedented national-scale detailed study, we analyzed the links between cancer mortality, socio-economic factors, and sources of environmental pollution in Italy, both at wider regional and finer provincial scales, with an artificial intelligence approach. Overall, we found that cancer mortality does not have a random or spatial distribution and exceeds the national average mainly when environmental pollution is also higher, despite healthier lifestyle habits. Our machine learning analysis of 35 environmental sources of pollution showed that air quality ranks first for importance concerning the average cancer mortality rate, followed by sites to be reclaimed, urban areas, and motor vehicle density. Moreover, other environmental sources of pollution proved to be relevant for the mortality of some specific cancer types. Given these alarming results, we call for a rearrangement of the priority of cancer research and care that sees the reduction and prevention of environmental contamination as a priority action to put in place in the tough struggle against cancer., Competing Interests: Declaration of competing interest The authors declare that they have no known competing financial interests or personal relationships that could have appeared to influence the work reported in this paper., (Copyright © 2022 The Authors. Published by Elsevier B.V. All rights reserved.)

Background: Persons with Down syndrome (DS) are presumed to be at high risk of severe CoVID-19, due to immune dysregulation and often compromised cardiopulmonary function. Aim of the present study is to assess epidemiological and clinical characteristics of individuals with DS deceased in Italian hospitals with CoVID-19., Methods: We used a nationwide database of 3,438 patients deceased with RT-PCR-confirmed SARS-CoV-2 infection in Italy (10.4% of all deaths with CoVID-19 in the country at the time of analysis). Data on demographics, pre-existing comorbidities and in-hospital complications leading to death were extracted from medical charts obtained from hospitals. Data on individuals with DS deceased with CoVID-19 were obtained from this sample., Results: Sixteen cases of death in individuals with DS (0.5% of all charts analyzed) were identified. Acute respiratory distress syndrome occurred in all 16 cases. Compared with individuals without DS, those with DS deceased with CoVID-19 were younger (52.3 ± 7.3 vs. 78.1 ± 10.6 years, p < .001) and presented a higher incidence of superinfections (31.2 vs. 13.0%, p = .029). Autoimmune diseases (43.8 vs. 4%, p < .001), obesity (37.5 vs. 11%, p = .009), and dementia (37.5 vs. 16.3%, p = .012) were more prevalent in individuals with DS. ICU admissions was similar in both groups (25 vs. 18.8%, p = .129)., Conclusions: Individuals with DS deceased with CoVID-19 are younger than individuals without DS. Comorbidity burden and increased risk of complications (i.e., bacterial superinfections) can influence CoVID-19 prognosis in individuals with DS. Specific strategies to prevent and mitigate the effects of CoVID-19 in the population with DS are needed., (© 2020 Wiley Periodicals LLC.)

Background: A likely increasing demand for varieties mixtures, landraces and genetic diversity in cropping systems will underpin calls for models able to generalize phenological development at the species level, at the same time as providing the expected range of phenological variability. In the present article, we aimed to obtain a generalized phenological model of durum wheat (Triticum durum, Desf.)., Results: Using a large phenological dataset embracing field data collected under different sowing dates, varieties and locations over the Italian peninsula, we searched for the phenophases enabling the best linear approximations between developmental rates and air temperature, aiming to minimize the residual variability from drivers other than temperature, as genetic and environmental diversity. The developmental rates of the resulting phases were then examined with respect to the mean daylength to determine possible additional relations with photoperiod. If a correlation with daylength was also present, the developmental rate is calibrated by multiple linear regression, or otherwise by simple linear regression of temperature. The resulting calibration, tested on an independent data subset, confirms that the model is able to generalize wheat development over the Italian peninsula with high accuracy (mean absolute error =3-8 days; r 2  = 0.75-0.98), regardless of the wheat variety., Conclusion: The generalized phenological model is potentially suitable for many agro-ecological and large-scale applications. It is hoped that the model will aid in situations where phenological observations to parameterize a model are still lacking, as is probably the case for landraces and underutilized crop varieties. © 2019 Society of Chemical Industry., (© 2019 Society of Chemical Industry.)

Multimorbidity, the coexistence of several chronic conditions in a patient, represents a great challenge for healthcare systems and society. The Integrated Multimorbidity Care Model (IMCM) was recently designed within the Joint Action on chronic diseases and promoting healthy ageing across the life cycle (CHRODIS) to ensure the continuity of care for patients with multimorbidity. The IMCM was implemented in five European pilot sites in Spain, Italy, and Lithuania, within the Joint Action CHRODIS-PLUS. The effect of these pilot interventions was assessed pre- and post-implementation by 17 healthcare managers, using the Assessment of Chronic Illness Care (ACIC) measure, and by 226 patients with the Patient Assessment of Care for Chronic Conditions (PACIC+) survey. The ACIC total score significantly increased (5.23 to 6.71, p = 0.022) after the intervention, with differences across sites. A significant increase in the PACIC+ summary score was found ranging from 3.25 at baseline to 4.03 after the intervention ( p < 0.001), and 58% of the sample perceived an improvement in care. Higher PACIC+ scores after the intervention were associated to lower baseline values in the respective PACIC+ dimension and to greater changes in ACIC Part 1 (delivery system organization). The IMCM implementation can help improve the quality of care for patients with multimorbidity.