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The relationship between adolescents' use of video games and their well-being is controversial and largely unexplored during the COVID -19 pandemic. This study examined the association between adolescent video game use and well-being during a nationwide lockdown (March-May 2020) and investigated whether this association was mediated by emotional self-efficacy and moderated by positive coping. The study involved 168 Italian adolescents aged 14-19 years (M = 16.6 years, SD = 1.6). Data were collected through an anonymous online questionnaire. Moderated mediation analysis showed that playing video games was indirectly associated with lower health complaints and higher affective well-being by mediating emotional self-efficacy. In addition, positive coping was found to moderate the relationship between video game use and emotional self-efficacy. Results indicate that both emotional self-efficacy and positive coping enabled adolescents to benefit from playing video games in terms of individual well-being during home confinement.

Knowledge about the role of empathy, emotional self-efficacy, and loneliness on early adolescents' depressive symptoms is scarce. The main aims of the study were to investigate the following: (a) the role of empathy and emotional self-efficacy (additive and interactive) on loneliness and depressive symptoms, taking into account gender differences and (b) the possible mediating role of loneliness in the relationship between emotional predictors and depressive symptoms. Three hundred forty-eight Italian early adolescents (48% girls; mean age, 13; SD = 0.3) completed an anonymous self-report questionnaire at two time points (1 year apart). Structural equation modeling (SEM) was used to analyze data. Results indicated the following: (a) high empathy and low emotional self-efficacy were related to higher subsequent loneliness and depressive symptoms; (b) emotional self-efficacy moderated the relationship between empathy and loneliness and, only for girls, between empathy and depressive symptoms; (c) no mediation role of loneliness between emotional predictors (empathy and emotional self-efficacy) and depressive symptoms was found. Results are discussed in relation to preventive interventions targeting early adolescents.

Although drinking motives have been largely studied, research taking into account the Mediterranean drinking culture and focusing on motives specifically associated to adolescents' developmental tasks is lacking. For these reasons the study investigates drinking motives in a group of Italian adolescents and their relationships with drunkenness and high levels of alcohol consumption (wine, beer, spirits and alcopops). A self-report questionnaire on drinking motives and amount of alcohol use was administered to 784 adolescents, boys (46%) and girls, ages 15-19. Using confirmatory factor analysis and stepwise logistic regressions, we found that: 1) motives for drinking were coping, conformity, self-affirmation and experimentation-transgression; 2) coping motives were positively related to the high consumption of all alcoholic beverages and to drunkenness; 3) conformity motives were negatively related to high beer consumption and drunkenness, while experimentation-transgression motives were positively related to high alcopops consumption. Implications for prevention are discussed. (Contains 5 tables.)

Several lead objects were found gilded at the Royal Palace in Caserta (1752, Italy) and the gilding technique of nine of them was analysed. Historical research shows that lead was used because of its easy workability, wide availability, and low cost, and was also gilded like wood or stucco. XRF analysis made it possible to determine the elemental composition of the layering created for gilding, highlighting its characteristics and differences. Standard samples with similar features were made for the characterization of the stratigraphy of interest through the XRF technique. The novelty found in this study is that lead was also gilded using the gouache technique, that is a layering with gesso, Armenian bolus and gold leaf. The restoration interventions carried out in the past were highlighted. The results found are very useful for museum conservators and restorers as well as for research. [ABSTRACT FROM AUTHOR]

Background: Telemedicine is defined as "the use of medical information exchanged from one site to another via electronic communications to improve a patient's health status". This relatively new concept of healthcare is based on the fusion between medical assistance and Information and Communication Technology (ICT) to provide support to people located in remote and underserved areas. It can be found not only in hospitals, but also in other healthcare facilities such as pharmacies. Starting from 2010, telemedicine or telehealth was formally introduced in the Italian pharmaceutical context with the "Pharmacy of Services Decree". In spite of this regulatory framework, the implementation of this technology was very slow and there are no data about the spreading and use of these services in Italian pharmacies. Objective: The present study has therefore developed a survey to collect information on the diffusion of telemedicine/telehealth services within Italian pharmacies. Methods: A two-part questionnaire in Italian was developed using SurveyMonkey, setting a mechanism aimed to have different outcomes according to the answers given. Six hundred eighty-three respondents returned the questionnaire. The results were then analysed statistically. Results: The questionnaire results have shown a limited diffusion of telemedicine/telehealth services among Italian pharmacies and an apparently limited interest of health authorities in supporting the integration of this technology. Conclusions: More efforts should be spent by national public health stakeholders to better analyse the contribution of telemedicine services available in public pharmacies and to find the best solutions to implement this innovative technology as an established service. [ABSTRACT FROM AUTHOR]

On 30 October 1930, an Mw 5.8 earthquake hit the northern Marche coastal area (central Italy), causing significant damage (I0 VIII-IX degree Mercalli-Cancani-Sieberg) along a 40 km stretch of the Adriatic coast between Pesaro and Ancona, centered on the town of Senigallia. This area is characterized by relatively infrequent and moderate-sized earthquakes and by elusive active faults. In spite of the presence of well-known northwest-southeast-trending, northeast-verging fault-propagation folds forming the outer thrusts of the Apennines, the current level of activity, and the kinematics of these coastal structures are still controversial. We present a multidisciplinary analysis of the source of the 30 October 1930 Senigallia earthquake, combining instrumental and macroseismic data and elaborations with available evidence from geological and tectonic investigations. We determine the main seismic parameters of the source, including the earthquake location, its magnitude, and, for the first time, its focal mechanism, providing the first instrumental evidence for thrust faulting along the northern Marche coastal belt. Our findings provide conclusive evidence for the current activity of the northern Marche coastal thrusts. As such they have significant implications for the seismic hazard of the area, a densely populated region that hosts historical heritage, tourism facilities, industrial districts, and key transportation infrastructures. [ABSTRACT FROM AUTHOR]

The article informs that the citizens living within the perimeter of the polyclinic of Bari in Italy were analyzed for exposure to air pollution and noise. It further informs that the atmospheric concentration of particulate matter as revealed by the environmental survey is above the limit set by the law for the protection of human health. It mentions that excessive road traffic and transport are the major anthropogenic source for pollution.

The article presents a study on the evaluation of the age in the cephalopod Octopus vulgaris through several of its internal structure. The study employed octopus collected from the Bay of Naples, Italy, wherein the daily periodicity of ring deposition was validated using thermal shock marking. The results showed that the growth increments in the upper beak of the specie give a reliable aging method that can be used to assess the growth patterns in wild populations.

Abstract: This study analyzes the relationship between quality signals and price setting through the application of hedonic price functions. The model proposals also include variables relating to land use policies and tourism development strategies. A simultaneous equation model endogenously estimates quality signals. This method is appropriate for analyzing emerging urban destinations, as characterized by the presence of an expanding hotel industry. The results are based on a dataset of 145 hotels in Turin, Italy. The empirical findings reveal that reputation-based quality signals help explain tariff levels. Price proposals also include a premium for quality assured hotels, defining some limits of the current hotel classification system. The empirical evidence has significant marketing implications for the hospitality industry’s competitiveness, since the results clarify the impact of quality signals on price level. [Copyright &y& Elsevier]

The article presents a study on the efficiency of laparoscopy in the treatment of diseases in Italy. Laparoscopy is being used to treat gynecological malignancies, and in the management of benign ovarian cancer. However, the use of laparoscopy on the ovarian cancer surgery needs to be analyzed based on the its efficiency in assessing the ovarian cancer, and the reassessment of the disease. On the other hand, laparoscopy has several advantages because it reduces blood loss and limits hospital stay.

Habitat Suitability (HS) models have been extensively used by conservation planners to estimate the spatial distribution of threatened species and of species of commercial interest. In this work we compare three HS models for the estimation of commercial yield potential and the identification of suitable sites for Tapes philippinarum rearing in the Sacca di Goro lagoon (Italy) on the basis of six environmental factors. The habitat suitability index (HSI) is based on expert opinion while the habitat suitability conditional (HSC) is calibrated on observational data. The habitat suitability mixed (HSM) model is a two-part model combining expert knowledge and regression analysis: the first component of the model uses logistic regression to identify the areas in which clams are likely to be present; the second part applies the same parameter-specific suitability functions of the HSI model only in the areas previously identified as productive by the logistic component. The HS models were validated on an independent data set and estimates of potential yield of the Goro lagoon were compared. The effectiveness of the three approaches is then discussed in terms of predicted yield and identification of suitable sites for farming. [Copyright &y& Elsevier]

• A new method for the techno-economic optimization of building integrated photovoltaic is presented. • The method, to be used in early design, optimizes capacity and positions of the photovoltaic collectors and capacity of the electric storage to maximize the profitability of the system during its lifetime. • A large share of the electricity demand can be covered by photovoltaic systems in a profitable way with current prices and technologies. • Regarding building integrated photovoltaics, the maximization of the annual cumulative production is not always the best strategy. In this example installing photovoltaic modules on the façade can be economically advantageous even if the roof area is not fully occupied by PV. This paper presents a new method for the planning of photovoltaic systems in the early architectural design. The method finds capacity and position of a photovoltaic system over the envelope of a building by means of optimization. The input consists in: geometry of the building, surrounding shadings, local weather, hourly electric demand, unitary costs of the system and benefits for the production of electricity (sold or self-consumed). In the input there are known values (e.g. PV installation costs [€/kWp] or present costs for the electricity [€/kWh]) and unknown ones (e.g. degradation rate [%/year], maintenance costs [€/kWp year] or discount rate [%/year]). The optimization is performed using the expected value out of a set of parametric scenarios generated by the unknown input values. The results show that, if capacity and position of the system are tailored on its aggregated electric demand, a large penetration of photovoltaic electricity is profitable at current prices without incentives or valorization from the grid. The optimization performed with an arbitrary set of electric storages shows how the presence of storage fosters a higher optimal capacity for the PV system. This method has the potential to hugely expand the installation of urban photovoltaic. [ABSTRACT FROM AUTHOR]

Aims: To date, precision medicine has revolutionized the clinical management of Non-Small Cell Lung Cancer (NSCLC). International societies approved a rapidly improved mandatory testing biomarkers panel for the clinical stratification of NSCLC patients, but harmonized procedures are required to optimize the diagnostic workflow. In this context a knowledge-based database (Biomarkers ATLAS, https://biomarkersatlas.com/) was developed by a supervising group of expert pathologists and thoracic oncologists collecting updated clinical and molecular records from about 80 referral Italian institutions. Here, we audit molecular and clinical data from n = 1100 NSCLC patients collected from January 2019 to December 2020., Methods: Clinical and molecular records from NSCLC patients were retrospectively collected from the two coordinating institutions (University of Turin and University of Naples). Molecular biomarkers (KRAS, EGFR, BRAF, ROS1, ALK, RET, NTRK, MET) and clinical data (sex, age, histological type, smoker status, PD-L1 expression, therapy) were collected and harmonized., Results: Clinical and molecular data from 1100 (n = 552 mutated and n = 548 wild-type) NSCLC patients were systematized and annotated in the ATLAS knowledge-database. Molecular records from biomarkers testing were matched with main patients' clinical variables., Conclusions: Biomarkers ATLAS (https://biomarkersatlas.com/) represents a unique, easily managing, and reliable diagnostic tool aiming to integrate clinical records with molecular alterations of NSCLC patients in the real-word Italian scenario., Competing Interests: Declaration of competing interest Umberto Malapelle has received personal fees (as consultant and/or speaker bureau) from Boehringer Ingelheim, Roche, MSD, Amgen, Thermo Fisher Scientific, Eli Lilly, Diaceutics, GSK, Merck and AstraZeneca, Janssen, Diatech, Novartis and Hedera for work performed. Francesco Passiglia Francesco declared consultant/advisory fee from Astrazaneca, Janssen, Amgen, Sanofi, Brystol Myer Squibb, Merck Sharp and Dohne, Roche, Beigene, Novartis, Thermofisher Scientific. Pasquale Pisapia reports speaking fees from Novartis outside the submitted work. Diego Cortinovis has received personal fees (as consultant and/or speaker bureau) from Advisory Amgen, AstraZeneca, BMS, MSD, Novartis, Roche, Jannsen, Sanofi Genzyme.Domenico Galetta has received personal fees (as consultant and/or speaker bureau) from Astra-Zeneca, Pfizer, Eli-Lilly, BMS, MSD, Novartis, Amgen, Roche for work performed outside of the current study. Paolo Graziano has received personal fees (as consultant and/or speaker bureau) from: Amgen, AstraZeneca, BMS, Eli Lilly, MSD, Novartis, Roche, Pfizer, Boehringer Ingelheim unrelated to the current work. Fabio Pagni has received personal fees (as consultant and/or speaker bureau) from Novartis, Roche, MSD, Amgen, GSK and AstraZeneca, for work performed outside of the current study. Giulia Pasello has received personal fees (as consultant and/or speaker bureau) from: Amgen, AstraZeneca, BMS, Eli Lilly, MSD, Novartis, Roche, Jannsen, AstraZeneca, Roche unrelated to the current work. Sara Pilotto reports personal fees (invited speaker, advisory board) from AstraZeneca, Eli-Lilly, Novartis, AMGEN, Takeda, Sanofi, Bristol Myers Squibb, MSD and Roche; and research grants from AstraZeneca, Bristol Myers Squibb and Roche outside the submitted work. Marcello Tiseo reports personal fees (as consultant and/or speaker bureau) from Astra-Zeneca, Pfizer, Eli-Lilly, BMS, Novartis, Roche, MSD, Boehringer Ingelheim, Otsuka, Takeda, Pierre Fabre, Amgen, Merck, Sanofi. M.T. He received institutional research grants from Astra-Zeneca, Boehringer Ingelheim un related to the current work. Luisella Righi declared consultant/advisory fee from AstraZeneca, Novartis, Roche, Eli Lilly and Boehringer Ingelheim. Giancarlo Troncone reports personal fees (as speaker bureau or advisor) from Roche, MSD, Pfizer and Bayer, unrelated to the current work. Silvia Novello reports personal fees (as speaker bureau or advisor) from Eli Lilly, MSD, Roche, BMS, Takeda, Pfizer, Astra Zeneca and Boehringer Ingelheim, unrelated to the current work., (Copyright © 2024 The Authors. Published by Elsevier B.V. All rights reserved.)

Objective: To calculate the full cost of diagnostic pathology tests for Non-Small Cell Lung Cancer (NSCLC) across four Italian Pathology Units., Methods: Pathology Units were located in private (2) and public (2) hospitals distributed across the Italian territory (North: 2; Centre: 1; South: 1). Pathologists provided via questionnaire data on tests on NSCLC samples along with the identification and quantification of the necessary healthcare resources (diagnostic technologies, laboratory instruments and personnel). Resources were valued according to hospital-specific unit, yearly and hourly costs (disposables; technologies; professional clusters)., Results: The full cost per NSCLC tissue sample included histopathological immunophenotypic and required molecular analysis. Overall, it reached € 659.77 and it was mainly composed of direct costs (77.69%). The processing of a NSCLC tissue sample was labour intensive, as a relevant share of the full cost (44.98%) was actually due to personnel costs, with laboratory technicians, biologists and pathologist driving this finding (17.09%,12.43% and 10.81%, respectively)., Conclusions: The results of this research can facilitate the negotiation of new dedicated tariffs for NSCLC sample processing with the national or local third party-payers., (Copyright © 2023 Società Italiana di Anatomia Patologica e Citopatologia Diagnostica, Divisione Italiana della International Academy of Pathology.)

Immune-checkpoint inhibitors (ICIs) play a key role in the treatment of advanced stage colorectal cancer (CRC) patients featuring a deficient DNA mismatch repair (dMMR) system or a high microsatellite instability (MSI-H) profile. However, beyond the established role in CRC patients, ICIs have highly proven efficacy in other solid tumors featuring MSI-H/dMMR status represented by endometrial, gastric, ovarian, prostatic, and pancreatic carcinomas (EC, GC, OC, PrC, and PaC). Our aim was to compare the concordance rates among the Idylla™ MSI test, TapeStation 4200, and immunohistochemical (IHC) analysis in assessing MSI-H/dMMR status in EC, GC, OC, PrC, and PaC patients. The Sanger sequencing-based Titano MSI test was used in discordant cases. One hundred and eighty-five cases ( n = 40 PrC, n = 39 GC, n = 38 OC, n = 35 PaC, and n = 33 EC) were retrospectively selected. MMR protein expression was evaluated by IHC. After DNA quality and quantity evaluations, the Idylla TM and TapeStation 4200 platforms were adopted for the evaluation of MSI status. Remarkably, compared to IHC, the Idylla™ platform achieved a global concordance rate of 94.5% (154/163) for the microsatellite stable (MSS)/proficient MMR (pMMR) cases and 77.3% (17/22) for the MSI-H/dMMR cases. Similarly, a global concordance rate of 91.4% (149/163) and 68.2% (15/22) for MSS/pMMR and MSI-H/dMMR cases was also identified between IHC and the TapeStation 4200 microfluidic system. In addition, a global concordance of 93.1% (148/159) and 69.2% (18/26) for MSS/pMMR and MSI-H/dMMR cases was observed between the Idylla™ and TapeStation 4200 platforms. Discordant cases were analyzed using the Titano MSI kit. Overall, our data pinpointed a central role for molecular techniques in the diagnostic evaluation of dMMR/MSI-H status not only in CRC patients but also in other types of solid tumors.

Background: The deeper knowledge of non-small-cell lung cancer (NSCLC) biology and the discovery of driver molecular alterations have opened the era of precision medicine in lung oncology, thus significantly revolutionizing the diagnostic and therapeutic approach to NSCLC. In Italy, however, molecular assessment remains heterogeneous across the country, and numbers of patients accessing personalized treatments remain relatively low. Nationwide programs have demonstrated that the creation of consortia represent a successful strategy to increase the number of patients with a molecular classification., Patients and Methods: The Alliance Against Cancer (ACC), a network of 25 Italian Research Institutes, has developed a targeted sequencing panel for the detection of genomic alterations in 182 genes in patients with a diagnosis of NSCLC (ACC lung panel). One thousand metastatic NSCLC patients will be enrolled onto a prospective trial designed to measure the sensitivity and specificity of the ACC lung panel as a tool for molecular screening compared to standard methods., Results and Conclusion: The ongoing trial is part of a nationwide strategy of ACC to develop infrastructures and improve competences to make the Italian research institutes independent for genomic profiling of cancer patients., (Copyright © 2020. Published by Elsevier Inc.)

Purpose: Anaplastic lymphoma kinase (ALK) rearrangement confers sensitivity to ALK inhibitors (ALKis) in non-small-cell lung cancer (NSCLC). Although several drugs provided an impressive outcome benefit, the most effective sequential strategy is still unknown. We describe outcomes of real-life patients according to the treatment strategy received., Patients: We retrospectively collected 290 ALK rearranged advanced NSCLC diagnosed between 2011 and 2017 in 23 Italian institutions., Results: After a median follow-up of 26 months, PFS for crizotinib and a new generation ALKis were 9.4 [CI 95% 7.9-11.2] and 11.1 months [CI 95% 9.2-13.8], respectively, while TTF were 10.2 [CI 95% 8.5-12.6] and 11.9 months [CI 95% 9.7-17.4], respectively, being consistent across the different settings. The composed outcomes (the sum of PFS or TTF) in patients treated with crizotinib followed by a new generation ALKis were 27.8 months [CI 95% 24.3-33.7] in PFS and 30.4 months [CI 95% 24.7-34.9] in TTF. The median OS from the diagnosis of advanced disease was 39 months [CI 95% 31.8-54.5]. Patients receiving crizotinib followed by a new generation ALKis showed a higher median OS [57 months (CI 95% 42.0-73.8)] compared to those that did not receive crizotinib [38 months (CI 95% 18.6-NR)] and those who performed only crizotinib as target agent [15 months (CI 95% 11.3-34.0)] (P < 0.0001)., Conclusion: The sequential administration of crizotinib and a new generation ALKis provided a remarkable clinical benefit in this real-life population, being an interesting option to consider in selected patients.

Objectives: The discovery of tyrosine kinase inhibitors (TKI) has remarkably improved the clinical course of patients with non-small cell lung cancer driven by Epidermal Growth Factor Receptor (EGFR) mutations. However, virtually in all cases, the disease resurfaces in a TKI-resistant form that is mainly linked to an acquired EGFR-T790M mutation, a MET amplification, or small cell lung cancer (SCLC) transformation. Third-generation TKIs are able to block tumor growth through an irreversible binding to the T790M-mutated receptor. Such new treatments require the diagnostic analysis of new pathologic tissue or a liquid biopsy to detect the presence of the T790M mutation., Materials and Methods: Pre-TKI and post-TKI biopsies from 27 patients with an activating EGFR mutation were collected and analyzed for EGFR-T790M mutation, MET amplification, and SCLC transformation., Results: The T790M mutation was found in 16 patients (59%) whereas MET gene amplification was found in 2 (10.5%) of 19 evaluated cases. The histologic transformation from adenocarcinoma (ADC) to SCLC was identified in 3 patients (11%). In one of them reversal from SCLC back to adenocarcinoma was observed. One patient had the T790M mutation concordantly detected in 2 synchronous lesions whereas another patient showed T790M positivity only in one of 2 specimens. In 4 patients longitudinal biopsies revealed T790M gains and losses not always according to biological expectations., Conclusions: Intrapatient molecular or histologic heterogeneity may be frequently found during routine treatment of non-small cell lung cancer patients. This biological aspect may have profound repercussions on subsequent therapeutic decisions, and therefore requires in-depth investigation.