1. Alpha thalassaemia in an Italian population.
- Author
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Velati C, Sampietro M, Biassoni M, Cappellini MD, Wainscoat JS, Higgs DR, and Fiorelli G
- Subjects
- Chromosome Deletion, Fetal Blood analysis, Globins genetics, Hemoglobins, Abnormal analysis, Humans, Infant, Newborn, Italy, Thalassemia blood, Thalassemia genetics, Thalassemia epidemiology
- Abstract
The incidence of alpha-thalassaemia in an Italian population has been determined by a survey of random cord bloods for the presence of Hb Bart's. 144 out of 4730 (3%) had detectable amounts of Hb Bart's. Furthermore, alpha-globin gene analysis of 100 random cord bloods showed that five out of 100 had the common type of alpha-thalassaemia caused by a single alpha-globin gene deletion (-alpha). The molecular basis of alpha-thalassaemia was also determined in a selected group of 34 newborns with detectable levels of Hb Bart's. 25 of these cases had the -alpha 3.7 deletion type of alpha-thalassaemia and nine had nondeletion types of alpha-thalassaemia in four of which the molecular defect was detectable directly by restriction enzyme analysis.
- Published
- 1986
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