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Moment tensor inversions of broadband velocity data are usually managed by adopting Green's functions for 1D layered seismic wave speed models. This assumption can impact on source parameter estimates in regions with complex 3D heterogeneous structures and discontinuities in rock properties. In this work, we present a new centroid moment tensor (CMT) catalog for the Amatrice‐Visso‐Norcia (AVN) seismic sequence based on a recently generated 3D wave speed model for the Italian lithosphere. Forward synthetic seismograms and Fréchet derivatives for CMT‐3D inversions of 159 earthquakes with Mw ≥ 3.0 are simulated using a spectral‐element method (SEM) code. By comparing the retrieved solutions with those from time domain moment tensor (TDMT) catalog, obtained with a 1D wave speed model calibrated for Central Apennines (Italy), we observe a remarkable degree of consistency in terms of source geometry, kinematics, and magnitude. Significant differences are found in centroid depths, which are more accurately estimated using the 3D model. Finally, we present a newly designed parameter, τ, to better quantify and compare a‐posteriori the reliability of the obtained MT solutions. τ measures the goodness of fit between observed and synthetic seismograms accounting for differences in amplitude, arrival time, percentage of fitted seconds, and the usual L2‐norm estimate. The CMT‐3D solutions represent the first Italian CMT catalog based on a full‐waveform 3D wave speed model. They provide reliable source parameters with potential implications for the structures activated during the sequence. The developed approach can be readily applied to more complex Italian regions where 1D models are underperforming and not representative of the area. Plain Language Summary: The moment tensor (MT) is a mathematical representation of the movement on a fault during an earthquake, and of the size, or magnitude, of the event. Such tensor is often described through the beachballs, a graphic symbol that indicates the fault orientation and the type of slip that occurs during an earthquake. Usually, seismologists use 1D wave speed models (i.e., describing only the vertical velocity of seismic waves in the Earth interior) in order to compute MTs. In recent years, due to the incredible progresses of computer sciences, also 3D models, which are able to describe lateral velocity variations, have been successfully adopted to compute MTs. In this work, we use the recently developed 3D Italian wave speed model "IMAGINE_IT" ("Im25" for brevity) to compute the MT solutions for the Amatrice‐Visso‐Norcia (AVN) 2016–2018 earthquakes with magnitude larger than 3. This seismic sequence ruptured almost 80 km of the Apennines normal faults and resulted in 299 casualties and >20,000 homeless. Our newly developed MT catalog allows us to better understand the characteristics of the faults activated during the seismic sequence and to provide more reliable source parameters as magnitude and depth. Key Points: A new centroid moment tensor catalog for Central Italy earthquakes has been built based on a 3D wave speed model for the Italian lithosphereMoment magnitude, kinematic source parameters, and centroid depths inferred with a 3D wave speed model are accurately estimatedThe goodness of moment tensor solutions is tested via a newly designed quality factor [ABSTRACT FROM AUTHOR]

A breast unit is a multidisciplinary center specialized in the management of women with breast diseases, including breast cancer (BC). It represents a care path, passing from screening activities to diagnostic investigations, from surgery to the definition of the therapeutic strategy, from psychophysical rehabilitation to long-term checks (follow-up), and up to genetic counseling. Since 2006, following a resolution issued by the European Parliament to urge member states to activate multidisciplinary breast centers by 2016, work has been underway throughout Italy to improve the management of women with BC. In Italy, the State-Regions agreement was signed on 18 December 2014, sanctioning the establishment of breast units. These centers must adhere to specific quality criteria and requirements. In 2020, the experts of the EUSOMA group (European Society of Breast Cancer Specialists), in their latest document published, expanded the requirements of the breast units. Furthermore, Senonetwork was founded in 2012 with the aim of allowing BC to be treated in breast units that comply with European requirements to ensure equal treatment opportunities for all Italian women. Indeed, the available data indicate that the BC patient has a greater chance of better treatment in the breast units with a multidisciplinary team, thus increasing the survival rate with a better quality of life, compared to those managed in nonspecialized structures. The present review is a perspective on the current Italian reality of breast units, updated with the available literature and the most recent epidemiological data from Senonetwork and AgeNaS., (Copyright © 2023 Wolters Kluwer Health, Inc. All rights reserved.)

Background: De-escalation of axillary surgery in breast cancer (BC) management began when sentinel lymph node biopsy (SLNB) replaced axillary lymph node dissection (ALND) as standard of care in patients with node-negative BC. The second step consolidated ALND omission in selected subgroups of BC patients with up to two macrometastases and recognized BC molecular and genomic implication in predicting prognosis and planning adjuvant treatment. Outcomes from the recent RxPONDER and monarchE trials have come to challenge the previous cut-off of two SLN in order to inform decisions on systemic therapies for hormone receptor-positive (HR+), human epidermal growth factor receptor type-2 (HER2) negative BC, as the criteria included a cut-off of respectively three and four SLNs. In view of the controversy that this may lift in surgical practice, the Italian National Association of Breast Surgeons (Associazione Nazionale Italiana Senologi Chirurghi, ANISC) reviewed data regarding the latest trials on this topic and proposes an implementation in clinical practice., Material and Methods: We reviewed the available literature offering data on the pathological nodal status of cN0 breast cancer patients., Results: The rates of pN2 status in cN0 patients ranges from 3.5 % to 16 %; pre-surgical diagnostic definition of axillary lymph node status in cN0 patients by ultrasound could be useful to inform about a possible involvement of ≥4 lymph nodes in this specific sub-groups of women., Conclusions: The Italian National Association of Breast Surgeons (ANISC) considers that for HR + HER2-/cN0-pN1(sn) BC patients undergoing breast conserving treatment the preoperative workup should be optimized for a more detailed assessment of the axilla and the technique of SLNB should be optimized, if considered appropriate by the surgeon, not considering routine ALND always indicated to determine treatment recommendations according to criteria of eligibility to RxPONDER and monarch-E trials., (© 2024 Published by Elsevier Ltd.)

Background: Microinvasive breast cancer is an uncommon pathological entity. Owing to the rarity of this condition, its surgical axillary management and overall prognosis remain controversial., Methods: A database was analysed to identify patients with microinvasive ductal carcinoma in situ (DCIS) who had surgery for invasive breast cancer at the European Institute of Oncology, Milan, between 1998 and 2010. Women who had undergone axillary staging by sentinel lymph node biopsy were included in the study., Results: Of 257 women with microinvasive breast cancer who underwent sentinel lymph node biopsy (SLNB), 226 (87·9 per cent) had negative sentinel lymph nodes (SLNs) and 31 had metastatic SLNs. Twelve patients had isolated tumour cells (ITCs), 14 had micrometastases and five had macrometastases in sentinel nodes. Axillary lymph node dissection was performed in 16 of the 31 patients with positive SLNs. After a median follow-up of 11 years, only one regional first event was observed in the 15 patients with positive SLNs who did not undergo axillary lymph node dissection. There were no regional first events in the 16 patients with positive SLNs who had axillary dissection., Conclusion: Good disease-free and overall survival were found in women with positive SLNs and microinvasive DCIS. This study is in line with studies showing that SLNB in microinvasive DCIS may not be useful, and supports the evidence that less surgery can provide the same level of overall survival with better quality of life., (© 2019 BJS Society Ltd. Published by John Wiley & Sons Ltd.)