7 results on '"Napolitano, Maria"'
Search Results
2. Uncovering the worth of the past: the relationship between corporate museums' strategic orientation and dual performance.
- Author
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Riviezzo, Angelo, Mason, Michela Cesarina, Garofano, Antonella, and Napolitano, Maria Rosaria
- Subjects
MUSEUMS ,ECONOMIC indicators ,STRUCTURAL models ,CORPORATE websites ,PRIVATE companies ,ORGANIZATIONAL performance - Abstract
Purpose: The main aim of the study is to empirically investigate the relationship between strategic orientation and a dual conceptualization of performance (i.e. non-economic performance and economic performance) in the research context of corporate museums, which are owned and run by private companies. Furthermore, the study aims to explore the nature of the relationship between the dual performance, shedding light on the relevance of non-economic results for this peculiar category of museums. Design/methodology/approach: The study is based on survey data from 105 Italian corporate museums, which represent almost the entire population in the country (91%). A structural model was estimated using SmartPLS software in order to examine the direct and indirect effects of strategic orientation on corporate museums' non-economic and economic performance. Findings: The findings show that only if corporate museums are able to achieve non-economic performance, creating value for the owning company and the local community, they can also have good results in economic terms. Thus, the non-economic performance acts as a mediator into the relationship between strategic orientation and economic performance. Originality/value: The current work is a pioneer study for the empirical investigation of performance within corporate museums. The empirical model of the study, based on a dual conceptualization of performance and a mediation analysis, is completely innovative in this research context. [ABSTRACT FROM AUTHOR]
- Published
- 2022
- Full Text
- View/download PDF
3. Glycated ACE2 receptor in diabetes: open door for SARS-COV-2 entry in cardiomyocyte.
- Author
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D'Onofrio, Nunzia, Scisciola, Lucia, Sardu, Celestino, Trotta, Maria Consiglia, De Feo, Marisa, Maiello, Ciro, Mascolo, Pasquale, De Micco, Francesco, Turriziani, Fabrizio, Municinò, Emilia, Monetti, Pasquale, Lombardi, Antonio, Napolitano, Maria Gaetana, Marino, Federica Zito, Ronchi, Andrea, Grimaldi, Vincenzo, Hermenean, Anca, Rizzo, Maria Rosaria, Barbieri, Michelangela, and Franco, Renato
- Subjects
COVID-19 ,ANGIOTENSIN converting enzyme ,SARS-CoV-2 ,COVID-19 pandemic ,PROTEIN domains - Abstract
Rationale: About 50% of hospitalized coronavirus disease 2019 (COVID-19) patients with diabetes mellitus (DM) developed myocardial damage. The mechanisms of direct SARS-CoV-2 cardiomyocyte infection include viral invasion via ACE2-Spike glycoprotein-binding. In DM patients, the impact of glycation of ACE2 on cardiomyocyte invasion by SARS-CoV-2 can be of high importance. Objective: To evaluate the presence of SARS-CoV-2 in cardiomyocytes from heart autopsy of DM cases compared to Non-DM; to investigate the role of DM in SARS-COV-2 entry in cardiomyocytes. Methods and results: We evaluated consecutive autopsy cases, deceased for COVID-19, from Italy between Apr 30, 2020 and Jan 18, 2021. We evaluated SARS-CoV-2 in cardiomyocytes, expression of ACE2 (total and glycosylated form), and transmembrane protease serine protease-2 (TMPRSS2) protein. In order to study the role of diabetes on cardiomyocyte alterations, independently of COVID-19, we investigated ACE2, glycosylated ACE2, and TMPRSS2 proteins in cardiomyocytes from DM and Non-DM explanted-hearts. Finally, to investigate the effects of DM on ACE2 protein modification, an in vitro glycation study of recombinant human ACE2 (hACE2) was performed to evaluate the effects on binding to SARS-CoV-2 Spike protein. The authors included cardiac tissue from 97 autopsies. DM was diagnosed in 37 patients (38%). Fourth-seven out of 97 autopsies (48%) had SARS-CoV-2 RNA in cardiomyocytes. Thirty out of 37 DM autopsy cases (81%) and 17 out of 60 Non-DM autopsy cases (28%) had SARS-CoV-2 RNA in cardiomyocytes. Total ACE2, glycosylated ACE2, and TMPRSS2 protein expressions were higher in cardiomyocytes from autopsied and explanted hearts of DM than Non-DM. In vitro exposure of monomeric hACE2 to 120 mM glucose for 12 days led to non-enzymatic glycation of four lysine residues in the neck domain affecting the protein oligomerization. Conclusions: The upregulation of ACE2 expression (total and glycosylated forms) in DM cardiomyocytes, along with non-enzymatic glycation, could increase the susceptibility to COVID-19 infection in DM patients by favouring the cellular entry of SARS-CoV2. [ABSTRACT FROM AUTHOR]
- Published
- 2021
- Full Text
- View/download PDF
4. L'università come catalizzatore di relazioni per la valorizzazione del capitale territoriale.
- Author
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Napolitano, Maria Rosaria
- Subjects
COVID-19 ,PANDEMICS ,CENTRALITY ,EVIDENCE ,CONCRETE ,ORGANIZATIONAL commitment - Abstract
Copyright of Il Capitale Culturale: Studies on the Value of Cultural Heritage is the property of Il Capitale Culturale Studies on the Value of Cultural Heritage and its content may not be copied or emailed to multiple sites or posted to a listserv without the copyright holder's express written permission. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract. (Copyright applies to all Abstracts.)
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- 2020
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- View/download PDF
5. Epidemiology and Pattern of Resistance of Gram-Negative Bacteria Isolated from Blood Samples in Hospitalized Patients: A Single Center Retrospective Analysis from Southern Italy.
- Author
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Di Carlo, Paola, Serra, Nicola, Lo Sauro, Sofia, Carelli, Vincenza Maria, Giarratana, Maurizio, Signorello, Juan Camilo, Lucchesi, Alessandro, Manta, Giuseppe, Napolitano, Maria Santa, Rea, Teresa, Cascio, Antonio, Sergi, Consolato Maria, Giammanco, Anna, and Fasciana, Teresa
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KLEBSIELLA pneumoniae ,GRAM-negative bacteria ,HOSPITAL patients ,SURVIVAL rate ,ACINETOBACTER baumannii ,BLOOD sampling - Abstract
Background: Blood culturing remains the mainstream tool to inform an appropriate treatment in hospital-acquired bloodstream infections and to diagnose any bacteremia. Methods: A retrospective investigation on the prevalence of Gram-negative bacteria (GNB) and their resistance in hospitalized patients by age, sex, and units from blood cultures (BCs) was conducted from January 2018 to April 2020 at Sant'Elia hospital, Caltanissetta, southern Italy. We divided the patient age range into four equal intervals. Results: Multivariate demographic and microbiological variables did not show an association between bacteria distributions and gender and age. The distribution by units showed a higher prevalence of Klebsiella pneumoniae and Acinetobacter baumannii in the intensive care unit (ICU) and Escherichia coli in the non-intensive care units (non-ICUs). The analysis of antibiotic resistance showed that E. coli was susceptible to a large class of antibiotics such as carbapenem and trimethoprim-sulfamethoxazole. K. pneumoniae showed a significant susceptibility to colistin, tigecycline, and trimethoprim-sulfamethoxazole. From the survival analysis, patients with E. coli had a higher survival rate. Conclusions: The authors stress the importance of the implementation of large community-level programs to prevent E. coli bacteremia. K. pneumoniae and E. coli susceptibility patterns to antibiotics, including in the prescription patterns of general practitioners, suggest that the local surveillance and implementation of educational programs remain essential measures to slow down the spread of resistance and, consequently, increase the antibiotic lifespan. [ABSTRACT FROM AUTHOR]
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- 2021
- Full Text
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6. Epidemiological and clinical characteristics of imported malaria in adults in Milan, Italy, 2010-2015.
- Author
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Antinori S, Napolitano M, Grande R, Passerini S, Ridolfo AL, Galimberti L, Oreni L, Schinaia S, Milazzo L, Galli M, Corbellino M, Gismondo MR, Zanchetta N, Cordier L, and Rizzardini G
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- Adult, Antimalarials therapeutic use, Communicable Diseases, Imported diagnosis, Communicable Diseases, Imported parasitology, Emigrants and Immigrants statistics & numerical data, Female, Humans, Italy epidemiology, Malaria diagnosis, Malaria drug therapy, Male, Middle Aged, Retrospective Studies, Travel, Communicable Diseases, Imported epidemiology, Malaria epidemiology
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- 2018
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7. Lauroside B, a megastigmane glycoside from Laurus nobilis (bay laurel) leaves, induces apoptosis in human melanoma cell lines by inhibiting NF-κB activation.
- Author
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Panza E, Tersigni M, Iorizzi M, Zollo F, De Marino S, Festa C, Napolitano M, Castello G, Ialenti A, and Ianaro A
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- Antineoplastic Agents, Phytogenic chemistry, CASP8 and FADD-Like Apoptosis Regulating Protein genetics, CASP8 and FADD-Like Apoptosis Regulating Protein metabolism, Drug Screening Assays, Antitumor, Glycosides chemistry, Humans, I-kappa B Kinase antagonists & inhibitors, I-kappa B Kinase metabolism, Italy, Melanoma metabolism, Molecular Structure, NF-kappa B antagonists & inhibitors, NF-kappa B metabolism, Norisoprenoids chemistry, Plant Leaves chemistry, Poly(ADP-ribose) Polymerases metabolism, X-Linked Inhibitor of Apoptosis Protein genetics, X-Linked Inhibitor of Apoptosis Protein metabolism, Antineoplastic Agents, Phytogenic isolation & purification, Antineoplastic Agents, Phytogenic pharmacology, Apoptosis drug effects, Glycosides isolation & purification, Glycosides pharmacology, Laurus chemistry, Melanoma drug therapy, NF-kappa B drug effects, Norisoprenoids isolation & purification, Norisoprenoids pharmacology
- Abstract
Malignant melanoma is a highly aggressive tumor that frequently resists chemotherapy, so the search for new agents for its treatment is of great importance. In the present study, the antiproliferative propensity against human melanoma cell lines of lauroside B (1), a megastigmane glycoside isolated from Laurus nobilis (bay laurel) leaves, was investigated. This compound suppressed the proliferation of three human melanoma cell lines, namely, A375, WM115, and SK-Mel-28. The 1-induced inhibition of human melanoma cell proliferation was due to the induction of apoptosis, as demonstrated by FACS analysis with annexin V/PI staining and confirmed by activation of caspase-3 and by the cleavage of poly(ADP-ribose) polymerase (PARP). Growing evidence implicates NF-κB as an important contributor to metastasis and increased chemoresistance of melanoma. Thus, it was hypothesized that 1-induced apoptosis could be associated with suppression of NF-κB activation. The results showed that exposure of human melanoma cells to 1 inhibited IκB-α degradation and constitutive NF-κB DNA-binding activity as well as the expression, regulated by NF-κB, of two antiapoptotic genes, XIAP and c-FLIP. Induction of apoptosis by 1 in human aggressive melanoma cell lines has a potential high biological value.
- Published
- 2011
- Full Text
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