1. Obesity Is Strongly Associated With Low Testosterone and Reduced Penis Growth During Development.
- Author
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Mancini M, Pecori Giraldi F, Andreassi A, Mantellassi G, Salvioni M, Berra CC, Manfrini R, Banderali G, and Folli F
- Subjects
- Adolescent, Adult, Child, Child, Preschool, Cross-Sectional Studies, Endocrine System Diseases blood, Follow-Up Studies, Humans, Infant, Infant, Newborn, Italy epidemiology, Longitudinal Studies, Male, Penis growth & development, Penis metabolism, Prognosis, Young Adult, Endocrine System Diseases epidemiology, Pediatric Obesity physiopathology, Penis pathology, Testosterone blood
- Abstract
Context: Growth of male genitalia represents an important marker of sexual development. Testicle size is the primary measure and little is known regards penile length changes during puberty., Objective: This work aims to assess penis growth and testosterone levels in obese vs normal-weight children and adolescents, to evaluate a possible influence of obesity on genital development in boys, and to establish a new method for measuring penis length that allows comparison of normal-weight and overweight boys., Methods: We assessed anthropometric and genital development in 1130 boys from birth to age 20 years. Testosterone levels were also measured. A new method for penile length measurement was employed to minimize errors when comparing obese and nonobese children. Penis length was measured with a gentle, painless, straight positioning on a centimetric ruler without stretching, which is doable from the first years of life until the end of adolescence., Results: Penis length and testosterone are strongly related in children during puberty. Penile length growth is significantly decreased (by about 10%) in obese boys when compared to normal-weight boys, with concomitantly reduced testosterone levels, across puberal phases., Conclusion: Childhood obesity represents an important determinant of lower testosterone level and reduced penis development. A new method should be employed to improve penis measurement in normal-weight and overweight/obese boys. The possible significance of these observations for adult genital development and reproductive potential will require large longitudinal studies., (© The Author(s) 2021. Published by Oxford University Press on behalf of the Endocrine Society. All rights reserved. For permissions, please e-mail: journals.permissions@oup.com.)
- Published
- 2021
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