1. European 2--a clonal complex of Mycobacterium bovis dominant in the Iberian Peninsula.
- Author
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Rodriguez-Campos S, Schürch AC, Dale J, Lohan AJ, Cunha MV, Botelho A, De Cruz K, Boschiroli ML, Boniotti MB, Pacciarini M, Garcia-Pelayo MC, Romero B, de Juan L, Domínguez L, Gordon SV, van Soolingen D, Loftus B, Berg S, Hewinson RG, Aranaz A, and Smith NH
- Subjects
- Animals, Cattle, Clonal Evolution, France, Genome, Bacterial, Genomics, Italy, Mycobacterium bovis isolation & purification, Phylogeny, Phylogeography, Polymorphism, Single Nucleotide, Portugal, Spain, Mycobacterium bovis classification, Mycobacterium bovis genetics
- Abstract
Mycobacterium bovis isolates from the Iberian Peninsula are dominated by strains with spoligotype patterns deleted for spacer 21. Whole-genome sequencing of three Spanish strains with spacer 21 missing in their spoligotype pattern revealed a series of SNPs and subsequent screening of a selection of these SNPs identified one in gene guaA that is specific to these strains. This group of strains from the Iberian Peninsula missing spoligotype spacer 21 represents a new clonal complex of M. bovis, defined by the SNP profile with a distinct spoligotype signature. We have named this clonal complex European 2 (Eu2) and found that it was present at low frequency in both France and Italy and absent from the British Isles., (Copyright © 2011 Elsevier B.V. All rights reserved.)
- Published
- 2012
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