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Your search keyword '"*ELECTROSPINNING"' showing total 5 results
Start Over Descriptor "*ELECTROSPINNING" Region japan
5 results on '"*ELECTROSPINNING"'

1. Development of Imeglimin Electrospun Nanofibers as a Potential Buccal Antidiabetic Therapeutic Approach.

Author

Alamer, Ali A., Alsaleh, Nasser B., Aodah, Alhassan H., Alshehri, Abdullah A., Almughem, Fahad A., Alqahtani, Sarah H., Alfassam, Haya A., and Tawfik, Essam A.

Subjects
*INSULIN, *NANOFIBERS, *DRUG solubility, *TYPE 2 diabetes, *PATIENT compliance, *INSULIN sensitivity, *HYPOGLYCEMIC agents
Abstract

The prevalence of type 2 diabetes (T2D) has been growing worldwide; hence, safe and effective antidiabetics are critically warranted. Recently, imeglimin, a novel tetrahydrotriazene compound, has been approved for use in T2D patients in Japan. It has shown promising glucose-lowering properties by improving pancreatic beta-cell function and peripheral insulin sensitivity. Nevertheless, it has several drawbacks, including suboptimal oral absorption and gastrointestinal (GI) discomfort. Therefore, this study aimed to fabricate a novel formulation of imeglimin loaded into electrospun nanofibers to be delivered through the buccal cavity to overcome the current GI-related adverse events and to provide a convenient route of administration. The fabricated nanofibers were characterized for diameter, drug-loading (DL), disintegration, and drug release profiles. The data demonstrated that the imeglimin nanofibers had a diameter of 361 ± 54 nm and DL of 23.5 ± 0.2 μg/mg of fibers. The X-ray diffraction (XRD) data confirmed the solid dispersion of imeglimin, favoring drug solubility, and release with improved bioavailability. The rate of drug-loaded nanofibers disintegration was recorded at 2 ± 1 s, indicating the rapid disintegration ability of this dosage form and its suitability for buccal delivery, with a complete drug release after 30 min. The findings of this study suggest that the developed imeglimin nanofibers have the potential to be given via the buccal route, thereby achieving optimal therapeutic outcomes and improving patient compliance. [ABSTRACT FROM AUTHOR]

Published
2023
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2. MORPHALOGY PVC NANOFIBER, PRODUCED BY ELECTROSPINNING METHOD.

Author

Le Quoc and Uspenskaya, Mayya V.

Subjects
*POLYVINYL chloride, *ELECTROSPINNING, *OPTICAL microscopes, *NANOFIBERS, *IMAGE processing, *FIBERS, *VOLTAGE-gated ion channels
Abstract

One of the most important characteristics investigated during the obtaining of polymer nanofibers is the mean fiber diameter, which depends on the technological parameters of the electrospinning process. Polyvinyl chloride (PVC) nanofibres were obtained on the NANON-01A, Japan. The following technological parameters were used to obtain nanofibers: voltage is in the range 15 to 30 kV, a solution feed rate is in the range of 0.3 to 1.0 mL/h, a distance between the collector and the tip of the syringe is in range 7.5 to 15 cm. During the work, the 15% solution of PVC in the mixture of solvents tetrahydrofuran: dimethylformamide (1:1 by volume) was used. The morphology of the polymer fibers was determined by micrographs obtained using an Olympus STM6 optical microscope. Images were processed in the ImageJ program. The mean diameter of the polymer fibers and their size distribution were determined from the photographs, depending on the feed rate of the solution and the applied voltage and the distance between the needle and the collector. It is shown that the feed rate of PVC solution, the applied voltage, the distance between the needle and the collector affects the mean diameter of electroformed nanofibers. Increasing the applied voltage from 15 kV to 30 kV leads to decrease in the diameter of the nanofibers from 350 nm to 270 nm. An increase in the feed rate of PVC solutions leads to an increase in the diameter of the obtained nanofibers from 320 nm to 450 nm with an increase in the feed rate of the solution from 0.3 to 1 mL/h. No change in the diameter of nanofibers was observed when changes the distance between the collector and the tip of the syringe. [ABSTRACT FROM AUTHOR]

Published
2019
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3. New Regenerative Medicine Findings from University of Fukui Described (Three-Dimensional Printer-Assisted Electrospinning for Fabricating Intricate Biological Tissue Mimics).

Subjects
REGENERATIVE medicine, TISSUES, ARTIFICIAL organs, ELECTROSPINNING, 3-D printers
Abstract

A recent report from the University of Fukui in Japan discusses new findings in regenerative medicine. The researchers used a 3D printer to create intricate biological tissue mimics by electrospinning nanofibers onto a gel template. The resulting structures matched their intended design dimensions and showed high elasticity and stretchability. The researchers believe that this method has the potential to be used in crafting artificial organs and creating foundational materials for cell culture scaffolds. [Extracted from the article]

Published
2023

4. Inorganic additives strengthen electrospun fibres.

Subjects
PATENTS, NANOFIBERS, ELECTROSPINNING, NONWOVEN textiles
Abstract

The article focuses on the electro spinning process which strengthens electro spun fibers through inorganic additives described in European Patent EP 2 108 718 of applicant Japan Vilene Co. Ltd. in Tokyo, Japan. It says that the Japan Vilene prepares a spinnable sol solution with an average 10,000 molecular weight for the inorganic additives to be present along the length of the resulting fiber. It adds that the sol solution was pumped to a stainless nozzle to produce the final nonwoven fabric.

Published
2010

5. Nanospider in Japan.

Subjects
NONWOVEN textiles, NANOFIBERS, ELECTROSPINNING, UNIVERSITIES & colleges
Abstract

The article reports that Ambic Corp. has started development work on electrospun nanofibre nonwoven fabrics in collaboration with Kyoto Institute of Technology and Fukui University in Japan under the foundation of Hyogo COE programme. An Elmarco Nanospider system is being installed at the plant of Ambic for processing a wide range of polymers. The programme consists of eight projects to create next generation products for the textile industry.

Published
2008

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