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Microplastics (MPs) are non-biodegradable substances that can sustain our environment for up to a century. What is more worrying is the incapability of modern technologies to annihilate MPs from om environment. One ramification of MPs is their impact on every kind of life form on this planet, which has been discussed ahead; that is why these substances are surfacing in everyday discussions of scholars and researchers. This paper discusses the overview of the global occurrence, abundance, analysis, and remediation techniques of MPs in the environment. This paper primarily reviews the event and abundance of MPs in coastal sediments and agricultural soil of three major Asian countries, India, China, and Japan. A significant concentration of MPs has been recorded from these countries, which affirms its strong presence and subsequent environmental impacts. Concentrations such as 73,100 MPs/kg in Indian coastal sediments and 42,960 particles/kg in the agricultural soil of China is a solid testimony to prove their massive outbreak in our environment and require urgent attention towards this issue. Conclusions show that human activities, rivers, and plastic mulching on agricultural fields have majorly acted as carriers of MPs towards coastal and terrestrial soil and sediments. Later, based on recorded concentrations and gaps, future research studies are recommended in the concerned domain; a dearth of studies on MPs influencing Indian agricultural soil make a whole sector and its consumer vulnerable to the adverse effects of this emerging contaminant. [Display omitted] • Film & fibre shaped microplastics (MPs) are more abundant in India, China and Japan. • Plastic mulching is the root cause of major MPs pollution in soil and sediment. • Estuarian soil/sediment are more prone to MPs pollution than terrestrial and coastal. • FT-IR is highly used for MPs identification; mass spectrometry & microscopy are least. • MPs work as a vector for metals, PPCPs, surfactants and antibiotic resistance genes (ARGs). [ABSTRACT FROM AUTHOR]

Japanese encephalitis virus (JEV) is the principal cause of viral encephalitis. The predominance of children among patients with encephalitis in areas where JEV is endemic that do not have immunization programs suggests that acquired immunity is critical in protecting adults against symptomatic JEV encephalitis. We characterized and compared the T cell response to nonstructural (NS) protein 3 between healthy individuals naturally exposed to JEV and patients in the convalescent phase of JEV encephalitis. The NS3 protein, used as a fusion to the 11--amino acid protein transduction domain of human immunodeficiency virus Tat, elicited CD4 + and T helper--dependent CD8 + T cell responses. The production of interferon (IFN)--γ by responding T cells was significantly higher in healthy donors than in patients, correlating strongly with acquired protective immunity to JEV. Furthermore, a striking inverse association between IFN-γ levels and the severity of postencephalitic sequelae in patients implicated a role of IFN-γ in recovery. [ABSTRACT FROM AUTHOR]