1. Usefulness of Hematological Inflammatory Markers in Predicting Severe Side-effects from Induction Chemotherapy in Head and Neck Cancer Patients.
- Author
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Mikoshiba T, Ozawa H, Saito S, Ikari Y, Nakahara N, Ito F, Watanabe Y, Sekimizu M, Imanishi Y, and Ogawa K
- Subjects
- Aged, Aged, 80 and over, Antineoplastic Combined Chemotherapy Protocols administration & dosage, Biomarkers blood, C-Reactive Protein metabolism, Chemotherapy-Induced Febrile Neutropenia blood, Chemotherapy-Induced Febrile Neutropenia diagnosis, Cisplatin adverse effects, Docetaxel adverse effects, Female, Fluorouracil adverse effects, Head and Neck Neoplasms blood, Head and Neck Neoplasms diagnosis, Humans, Hyponatremia blood, Hyponatremia diagnosis, Hyponatremia epidemiology, Incidence, Japan epidemiology, Lymphocyte Count, Male, Middle Aged, Nutritional Status, Platelet Count, Predictive Value of Tests, Retrospective Studies, Risk Factors, Serum Albumin, Human metabolism, Squamous Cell Carcinoma of Head and Neck blood, Squamous Cell Carcinoma of Head and Neck diagnosis, Time Factors, Treatment Outcome, Antineoplastic Combined Chemotherapy Protocols adverse effects, Chemotherapy-Induced Febrile Neutropenia epidemiology, Head and Neck Neoplasms drug therapy, Induction Chemotherapy adverse effects, Inflammation Mediators blood, Squamous Cell Carcinoma of Head and Neck drug therapy
- Abstract
Background: Induction chemotherapy (IC) for head and neck cancer (HNC) often causes severe side-effects. However, it has still been challenging to predict the adverse events. The present study aimed to evaluate the role of hematological inflammatory markers in predicting severe side-effects caused by IC., Materials and Methods: A total of 54 HNC patients who underwent IC were enrolled. The association between severe side-effects and pre-treatment hematological inflammatory markers [the C-reactive protein (CRP) to albumin ratio (CAR), the modified Glasgow Prognostic Score (mGPS), the neutrophil-to-lymphocyte ratio (NLR), and the platelet-to-lymphocyte ratio (PLR)] were evaluated., Results: In the univariate analysis, the incidence of whole severe side-effects (grade 4), febrile neutropenia (above grade 3), and hyponatremia (above grade 3) were significantly higher in the high CAR and high GPS groups. Multivariate analysis revealed that high CAR and mGPS were independent predictors of these side-effects., Conclusion: CAR and mGPS were significant predictors of severe side-effects. These data can potentially offer patients an improved quality of life during cancer therapy., (Copyright© 2019, International Institute of Anticancer Research (Dr. George J. Delinasios), All rights reserved.)
- Published
- 2019
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