1. Study of association between atrophic gastritis and body mass index: a cross-sectional study in 10,197 Japanese subjects.
- Author
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Watabe, Hirotsugu, Mitsushima, Toru, Derakhshan, Mohammad H, Yamaji, Yutaka, Okamoto, Makoto, Kawabe, Takao, Omata, Masao, and McColl, Kenneth E L
- Subjects
AGE distribution ,ASIANS ,ENZYMES ,GASTROSCOPY ,HELICOBACTER diseases ,HELICOBACTER pylori ,MEDICAL screening ,RESEARCH funding ,RISK assessment ,LOGISTIC regression analysis ,BODY mass index ,CROSS-sectional method ,BACTERIAL antibodies ,ODDS ratio ,ATROPHIC gastritis - Abstract
Objectives: The aim of this study was to elucidate the association between body mass index (BMI) and both Helicobacter pylori and atrophic gastritis.Methods: The study involved 10,197 subjects participating in a Japanese mass endoscopic gastric cancer screening program. Atrophic gastritis was assessed by pepsinogen I to II ratio.Results: In logistic regression models, BMI had an inverse association with atrophic gastritis, with the odds ratios (OR) decreasing progressively to 0.67 (95% confidence interval [CI] 0.57-0.79, P<0.0001) in the highest BMI quintiles (BMI >or=25.66) group compared with the lowest BMI quintiles (BMI <20.97) group. In linear regression models, atrophic gastritis predicted BMI (regression coefficient -0.326, 95% CI -0.469, -0.184, P<0.0001), whereas H. pylori antibody was not a predictor (regression coefficient 0.072, 95% CI -0.053, 0.198, P=0.3).Conclusions: A small, inverse association between BMI and atrophic gastritis was found in the general population. In contrast, no association was observed between H. pylori seropositivity and BMI. [ABSTRACT FROM AUTHOR]- Published
- 2009
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