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2 results on '"Ebe, Koji"'

1. ORAI1 Genetic Polymorphisms Associated with the Susceptibility of Atopic Dermatitis in Japanese and Taiwanese Populations.

Author

Wei-Chiao Chang, Chih-Hung Lee, Tomomitsu Hirota, Li-Fang Wang, Satoru Doi, Miyatake, Akihiko, Enomoto, Tadao, Tomita, Kaori, Sakashita, Masafumi, Yamada, Takechiyo, Fujieda, Shigeharu, Ebe, Koji, Saeki, Hidehisa, Takeuchi, Satoshi, Masutaka Furue, Wei-Chiao Chen, Yi-Ching Chiu, Wei Pin Chang, Chien-Hui Hong, and Edward Hsi

Subjects
ATOPIC dermatitis, SKIN inflammation, SINGLE nucleotide polymorphisms, GENETIC polymorphisms
Abstract

Atopic dermatitis is a chronic inflammatory skin disease. Multiple genetic and environmental factors are thought to be responsible for susceptibility to AD. In this study, we collected 2,478 DNA samples including 209 AD patients and 729 control subjects from Taiwanese population and 513 AD patients and 1027 control subject from Japanese population for sequencing and genotyping ORAI1. A total of 14 genetic variants including 3 novel single-nucleotide polymorphisms (SNPs) in the ORAI1 gene were identified. Our results indicated that a non-synonymous SNP (rs3741596, Ser218Gly) associated with the susceptibility of AD in the Japanese population but not in the Taiwanese population. However, there is another SNP of ORAI1 (rs3741595) associated with the risk of AD in the Taiwanese population but not in the Japanese population. Taken together, our results indicated that genetic polymorphisms of ORAI1 are very likely to be involved in the susceptibility of AD. [ABSTRACT FROM AUTHOR]

Published
2012
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2. ORAI1 genetic polymorphisms associated with the susceptibility of atopic dermatitis in Japanese and Taiwanese populations.

Author

Chang WC, Lee CH, Hirota T, Wang LF, Doi S, Miyatake A, Enomoto T, Tomita K, Sakashita M, Yamada T, Fujieda S, Ebe K, Saeki H, Takeuchi S, Furue M, Chen WC, Chiu YC, Chang WP, Hong CH, Hsi E, Juo SH, Yu HS, Nakamura Y, and Tamari M

Subjects
Calcium Channels metabolism, Cell Line, Chromosome Mapping, Dermatitis, Atopic epidemiology, Gene Expression Regulation, Gene Frequency genetics, Genetics, Population, Haplotypes genetics, Humans, Japan epidemiology, Linkage Disequilibrium genetics, Lymphocytes metabolism, ORAI1 Protein, RNA, Messenger genetics, RNA, Messenger metabolism, Skin metabolism, Skin pathology, Taiwan epidemiology, Asian People genetics, Calcium Channels genetics, Dermatitis, Atopic genetics, Genetic Predisposition to Disease, Polymorphism, Single Nucleotide genetics
Abstract

Atopic dermatitis is a chronic inflammatory skin disease. Multiple genetic and environmental factors are thought to be responsible for susceptibility to AD. In this study, we collected 2,478 DNA samples including 209 AD patients and 729 control subjects from Taiwanese population and 513 AD patients and 1027 control subject from Japanese population for sequencing and genotyping ORAI1. A total of 14 genetic variants including 3 novel single-nucleotide polymorphisms (SNPs) in the ORAI1 gene were identified. Our results indicated that a non-synonymous SNP (rs3741596, Ser218Gly) associated with the susceptibility of AD in the Japanese population but not in the Taiwanese population. However, there is another SNP of ORAI1 (rs3741595) associated with the risk of AD in the Taiwanese population but not in the Japanese population. Taken together, our results indicated that genetic polymorphisms of ORAI1 are very likely to be involved in the susceptibility of AD.

Published
2012
Full Text
View/download PDF

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