1. Two Japanese brothers with hereditary gamma-glutamyl transpeptidase deficiency.
- Author
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Iida M, Yasuhara T, Mochizuki H, Takakura H, Yanagisawa T, and Kubo H
- Subjects
- Amino Acid Metabolism, Inborn Errors diagnosis, Amino Acid Metabolism, Inborn Errors genetics, Amino Acids urine, Borohydrides chemistry, Chromatography, High Pressure Liquid, Cysteine metabolism, Dipeptides chemistry, Family Health, Glutathione metabolism, Glutathione urine, Humans, Japan, Male, Marfan Syndrome complications, Middle Aged, Siblings, Time Factors, gamma-Glutamyltransferase biosynthesis, gamma-Glutamyltransferase deficiency
- Abstract
We report on two Japanese brothers with hereditary deficiency in gamma-glutamyl transpeptidase. The propositus was 48 years old when he first visited our medical center and had a 51-year-old brother. The brothers were both tall and slender and had long limbs; the younger was diagnosed as having Marfan syndrome. Both patients both showed a tendency to retarded mental development. gamma-Glutamyltranspeptidase activity was below the detection limit of 1 IU/L in both patients. Glutathionaemia and glutathionuria were evident in both brothers. The analyses of sulphydryl compounds in the plasma (and serum for certain test items) and urine indicated high concentrations of glutathione, gamma-glutamylcysteine, cysteine and cysteinylglycine. Urine amino acid analysis on an automatic analyser showed a slightly increased excretion of cystine and a large peak in the citrulline position due, at least in part, to thio-compounds.
- Published
- 2005
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