1. Distinctive immunoglobulin VH gene usage in Japanese patients with chronic lymphocytic leukemia.
- Author
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Koiso H, Yamane A, Mitsui T, Matsushima T, Tsukamoto N, Murakami H, Miyawaki S, Nojima Y, and Karasawa M
- Subjects
- Adult, Aged, Aged, 80 and over, Female, Humans, Immunoglobulin Heavy Chains genetics, Immunoglobulin Variable Region genetics, Incidence, Japan, Leukemia, Lymphocytic, Chronic, B-Cell genetics, Leukemia, Lymphocytic, Chronic, B-Cell mortality, Male, Middle Aged, Neoplasm Proteins genetics, Risk Factors, Gene Expression Regulation, Leukemic, Immunoglobulin Heavy Chains biosynthesis, Immunoglobulin Variable Region biosynthesis, Leukemia, Lymphocytic, Chronic, B-Cell metabolism, Neoplasm Proteins biosynthesis, Somatic Hypermutation, Immunoglobulin genetics
- Abstract
The incidence of chronic lymphocytic leukemia (CLL) is low in Asian countries including Japan, while CLL is the most common type of leukemia in the west. To elucidate which factors contribute to the low frequency of CLL in Japan, we investigated immunoglobulin (Ig) heavy chain gene usage and somatic hypermutation status in 44 Japanese patients with CLL. Only one of these patients used V(H)1-69. The finding is in striking contrast to data from western countries, where the frequency of CLL expressing V(H)1-69 ranges from 12 to 21%.
- Published
- 2006
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