1. Prognostic and clinicopathological significance of C-reactive protein/albumin ratio (CAR) in patients with gastric cancer: A meta-analysis.
- Author
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Yu J, Liu H, Zeng X, Zhao Y, Jiang D, Lu H, and Qian J
- Subjects
- Adult, Aged, Aged, 80 and over, Biomarkers, Tumor blood, China epidemiology, Female, Humans, Japan epidemiology, Male, Middle Aged, Neoplasm Staging, Prognosis, Risk Factors, Sex Factors, Stomach Neoplasms epidemiology, Stomach Neoplasms pathology, Survival Rate, Tumor Burden, C-Reactive Protein analysis, Serum Albumin analysis, Stomach Neoplasms blood, Stomach Neoplasms mortality
- Abstract
Background: In recent years, many studies have explored the potential prognostic utility of C-reactive protein/albumin ratio (CAR) in patients with gastric cancer (GC), however, the results remain conflicting. We thus performed a meta-analysis to determine the association of CAR and prognosis of GC., Methods: This meta-analysis was conducted according to the Preferred Reporting Items for Systematic Reviews and Meta-Analyses (PRISMA) Statement. PubMed, Web of science, Embase, and Cochrane Library were searched. Hazard ratios (HRs) and 95% confidence intervals (CIs) for overall survival (OS) and cancer-specific survival (CSS) of included studies were pooled to estimate the prognostic value of CAR., Results: Eight studies with a total of 3,216 patients were included in this meta-analysis. High CAR was significantly associated with poor OS (HR = 1.59, 95%CI = 1.36-1.85, p<0.001) and worse CSS (HR = 1.65, 95%CI = 1.21-2.25, p = 0.002). In addition, high CAR was significantly associated with male sex (OR = 1.80, 95%CI = 1.31-2.47, p<0.001), advanced tumor stage (OR = 2.14, 95%CI = 1.48-3.09, p<0.001), and tumor size ≥3cm (OR = 2.69, 95%CI = 1.84-3.93, p<0.001)., Conclusion: Elevated pretreatment CAR is a prognostic marker of poor OS and CSS in patients with GC. Furthermore, high CAR levels are associated with clinicopathological features reflecting tumor progression., Competing Interests: The authors have declared that no competing interests exist.
- Published
- 2021
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