1. A Case of Adenocarcinoma of the Small Intestine in a Japanese Patient with Crohn Disease: A Report with Immunohistochemical and Oncogenic Analyses.
- Author
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Uesugi, H., Mitomi, H., Sada, M., Takahashi, H., Kobayashi, K., Igarashi, M., Katsumata, T., Ihara, A., Ohtani, Y., Ikeda, S., and Okayasu, I.
- Subjects
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ADENOCARCINOMA , *CROHN'S disease ,LARGE intestine cancer - Abstract
We report a rare case of Crohn disease accompanied by a small-bowel carcinoma that developed in a 54-year-old Japanese man. The ulcerating tumor, which histologically proved to be a poorly differentiated adenocarcinoma and dysplasia surrounding the carcinoma, was located in the diseased ileum. The Ki-67 immunoreactive epithelial cells were increased in regenerative mucosa as compared with values for normal mucosa. The Ki-67- and p53-positive cells were increased in dysplasia and carcinoma as compared with values for regenerative or normal mucosa. In contrast, the p21[sup WAF1/CIP1] immunoreactive cells were decreased in this order. Intense DCC (deleted in colorectal cancer) expression was constantly shown among normal, regenerative, dysplastic and cancerous tissues. No bcl-2 expression and c-Ki-ras mutations were apparent. In conclusion, enhanced epithelial cell proliferation, p53 overexpression, and decrease of p21[sup WAF1/CIP1] expression may predispose the small-bowel mucosa to dysplasia and carcinoma development in Crohn disease. [ABSTRACT FROM AUTHOR]
- Published
- 1999
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