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Density perturbations accompanying seismic waves are expected to generate prompt gravity perturbations preceding the arrival of P-waves. Vallée et al. (Science 358:1164–1168, 2017, https://doi.org/10.1126/science.aao0746) reported the detection of such pre-P-wave signals in broadband seismograms during the 2011 Tohoku-oki earthquake. Kimura et al. (Earth Planets Space 71:27, 2019, https://doi.org/10.1186/s40623-019-1006-x) considered that their detection involved some uncertain points, including a concern regarding their signal processing procedure. Specifically, to remove the instrumental response, Vallée et al. (2017) applied acausal deconvolution to the seismograms truncated at the P-wave arrivals. Generally, acausal deconvolution produces artifacts at the edge of the time window. However, they did not present quantitative assessment whether the detected signals were artifacts due to the signal processing. To avoid this concern, Kimura et al. (2019) employed another procedure that eliminated acausal processes, resulting in the detection of a pre-P-wave signal with a statistical significance of 7σ in stacked broadband seismograms. Subsequently, Vallée et al. (Earth Planets Space 71:51, 2019, https://doi.org/10.1186/s40623-019-1030-x) commented that the procedure employed by Kimura et al. (2019) for the signal detection was inappropriate because it dismissed the low-frequency components of data. Although we admit the loss of low-frequency components in the data in Kimura et al. (2019), Vallée et al. (2019) have not yet provided a full account of the validity of their own procedure. Here, we assessed the validity of the procedure employed by Vallée et al. (2017) by quantitatively evaluating the magnitude of the acausal artifacts. First, we investigated how the input acceleration waveform, having an ideal signal-like shape, was distorted by their procedure. Their acausal deconvolution indeed generated a large-amplitude terminal artifact; however, it was removed by the causal band-pass filtering performed after the deconvolution and consequently became negligible. Next, we constrained the maximum amplitude of the artifact due to the noise in a seismogram and showed that it was sufficiently small compared to the reported signal amplitudes. These results suggest that the signal waveforms seen after their procedure were not artifacts but were representing the input acceleration with sufficient accuracy. Namely, their procedure well functions as a detection method for pre-P-wave signals. In the context of this validation, we replied to the comments of Vallée et al. (2019). [ABSTRACT FROM AUTHOR]

Density perturbations accompanying seismic waves are expected to generate prompt gravity perturbations preceding the arrival of P-waves. Vallée et al. (Science 358:1164–1168, 2017, https://doi.org/10.1126/science.aao0746) reported the detection of such pre-P-wave signals in broadband seismograms during the 2011 Tohoku-oki earthquake. Kimura et al. (Earth Planets Space 71:27, 2019, https://doi.org/10.1186/s40623-019-1006-x) considered that their detection involved some uncertain points, including a concern regarding their signal processing procedure. Specifically, to remove the instrumental response, Vallée et al. (2017) applied acausal deconvolution to the seismograms truncated at the P-wave arrivals. Generally, acausal deconvolution produces artifacts at the edge of the time window. However, they did not present quantitative assessment whether the detected signals were artifacts due to the signal processing. To avoid this concern, Kimura et al. (2019) employed another procedure that eliminated acausal processes, resulting in the detection of a pre-P-wave signal with a statistical significance of 7σ in stacked broadband seismograms. Subsequently, Vallée et al. (Earth Planets Space 71:51, 2019, https://doi.org/10.1186/s40623-019-1030-x) commented that the procedure employed by Kimura et al. (2019) for the signal detection was inappropriate because it dismissed the low-frequency components of data. Although we admit the loss of low-frequency components in the data in Kimura et al. (2019), Vallée et al. (2019) have not yet provided a full account of the validity of their own procedure. Here, we assessed the validity of the procedure employed by Vallée et al. (2017) by quantitatively evaluating the magnitude of the acausal artifacts. First, we investigated how the input acceleration waveform, having an ideal signal-like shape, was distorted by their procedure. Their acausal deconvolution indeed generated a large-amplitude terminal artifact; however, it was removed by the causal band-pass filtering performed after the deconvolution and consequently became negligible. Next, we constrained the maximum amplitude of the artifact due to the noise in a seismogram and showed that it was sufficiently small compared to the reported signal amplitudes. These results suggest that the signal waveforms seen after their procedure were not artifacts but were representing the input acceleration with sufficient accuracy. Namely, their procedure well functions as a detection method for pre-P-wave signals. In the context of this validation, we replied to the comments of Vallée et al. (2019). [ABSTRACT FROM AUTHOR]

A driving stress of the Mw5.8 reverse-faulting Awaji Island earthquake (2013), southwest Japan, was investigated using focal mechanism solutions of earthquakes before and after the mainshock. The seismic records from regional high-sensitivity seismic stations were used. Further, the stress tensor inversion method was applied to infer the stress fields in the source region. The results of the stress tensor inversion and the slip tendency analysis revealed that the stress field within the source region deviates from the surrounding area, in which the stress field locally contains a reverse-faulting component with ENE–WSW compression. This local fluctuation in the stress field is key to producing reverse-faulting earthquakes. The existing knowledge on regional-scale stress (tens to hundreds of km) cannot predict the occurrence of the Awaji Island earthquake, emphasizing the importance of estimating local-scale (< tens of km) stress information. It is possible that the local-scale stress heterogeneity has been formed by local tectonic movement, i.e., the formation of flexures in combination with recurring deep aseismic slips. The coseismic Coulomb stress change, induced by the disastrous 1995 Mw6.9 Kobe earthquake, increased along the fault plane of the Awaji Island earthquake; however, the postseismic stress change was negative. We concluded that the gradual stress build-up, due to the interseismic plate locking along the Nankai trough, overcame the postseismic stress reduction in a few years, pushing the Awaji Island earthquake fault over its failure threshold in 2013. The observation that the earthquake occurred in response to the interseismic plate locking has an important implication in terms of seismotectonics in southwest Japan, facilitating further research on the causal relationship between the inland earthquake activity and the Nankai trough earthquake. Furthermore, this study highlighted that the dataset before the mainshock may not have sufficient information to reflect the stress field in the source region due to the lack of earthquakes in that region. This is because the earthquake fault is generally locked prior to the mainshock. Further research is needed for estimating the stress field in the vicinity of an earthquake fault via seismicity before the mainshock alone. [ABSTRACT FROM AUTHOR]

In 2016, Japanese Society of Chemotherapy and Japan Society for Surgical Infection presented the practical guideline for appropriate usage of antimicrobial agents to prevent postoperative infections. This study aims to exhibit the validity of the guideline as a series of effective strategies for prevention of surgical site infections (SSIs) during reconstructive surgery of the head and neck cancer. We retrospectively evaluated patients who underwent head and neck reconstructive surgery with free or pedicle flaps in a single institute in Japan between July 2010 and July 2020. We evaluated the incidence of SSIs, patient backgrounds, and microbiological characteristics on the basis of antimicrobial prophylaxis recommended by the guideline. Enrolled in this study were 102 patients in our institution who underwent head and neck reconstructive surgery with free or pedicle flaps between July 2010 and July 2020. In the period between January 2018 to July 2020 after the SSI guideline was advocated (SSI guideline period), the ratio of administration of sulbactam/ampicillin (SBT/ABPC) was significantly higher (P < 0.001) and the duration of prophylactic antimicrobial treatment was significantly shorter than in the period between July 2010 to December 2017 before the SSI guideline was advocated (Pre-SSI guideline period) (P < 0.001). Incidence of SSIs were similar, even when antibiotic use was changed to be short-term single-agent administration in accordance with the practical guideline. Adherence to the current Japanese practical guideline on appropriate antimicrobial prophylaxis for SSIs can shorten the duration of usage of antimicrobial treatment without increasing the risk for occurrence of SSIs. [ABSTRACT FROM AUTHOR]

Objectives: We investigated changes in prescriptions for antimicrobial agents to treat children with acute otitis media (AOM)., Methods: A descriptive study using an electronic medical record database. Of 199,896 patients enrolled between 2001 and 2019, a total of 10,797 were aged <16 years and had AOM as their first and primary disease (overall pediatric AOM cohort). In addition, 4786 patients with AOM without other comorbidities (pediatric AOM cohort) were included., Results: In the overall pediatric AOM cohort, the age distribution ranged from 11% to 23% for those younger than 2 years and from 66% to 77% for those younger than 6 years, with no change over time. In the pediatric AOM cohort, the antimicrobial prescription rate was 91% in 2001 but declined to 40% by 2019. Antimicrobial use increased from 0% to 75% for penicillins, whereas use of cephalosporins decreased from 84% to 10%. The prescription rate for acetaminophen alone increased from 33% to 58%. There were no differences in the incidence of adverse reactions among the prescribed antimicrobials., Conclusions: Due to education efforts and promotion of the proper use of antimicrobials through means such as the Clinical practice guidelines for the diagnosis and management of acute otitis media in children (2006) and the Manual of Antimicrobial Stewardship (2016), a change in the use of antimicrobials occurred, leading to a trend to more proper use of these agents., (Copyright © 2021 Japanese Society of Chemotherapy and The Japanese Association for Infectious Diseases. Published by Elsevier Ltd. All rights reserved.)