1. Studies on cytotoxic constituents in pericarps of Mallotus japonicus. IV.
- Author
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Arisawa M, Fujita A, Hayashi T, Morita N, Kikuchi T, and Tezuka Y
- Subjects
- Antineoplastic Agents, Phytogenic pharmacology, Chemical Phenomena, Chemistry, Humans, Japan, KB Cells drug effects, Phloroglucinol isolation & purification, Phloroglucinol pharmacology, Antineoplastic Agents, Phytogenic isolation & purification, Cell Survival drug effects, Plants, Medicinal analysis
- Abstract
Two new phloroglucinol derivatives, isomallotolerin (1) and isomallotochromanol (2), were isolated from the cytotoxic fraction of the pericarps of Mallotus japonicus. The new derivatives were identified as 3-(3-methyl-2-hydroxybut-3-enyl)-5-(3-acetyl-2,4-dihydroxy-5-methy l-6- methoxybenzyl)-phlorisobutyrophenone (1) and 6-acetyl-5,7-dihydroxy-8-(3-acetyl-2,4-dihydroxy-5-methyl-6-methoxybenzy l)-2,2- dimethyl-3-hydroxychroman (2) from chemical and spectral data. Isomallotolerin and its acetate were found to be cytotoxic to KB cell line.
- Published
- 1990
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