1. FDG-PET-positive ovarian thecoma with GLUT5 expression: Five cases.
- Author
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Bono, Yukiko, Mizumoto, Yasunari, Nakamura, Mitsuhiro, Iwadare, Jyunpei, Obata, Takeshi, and Fujiwara, Hiroshi
- Subjects
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COMPUTED tomography , *DEOXY sugars , *GENE expression , *MAGNETIC resonance imaging , *OVARIAN tumors , *PRECANCEROUS conditions , *RADIOPHARMACEUTICALS , *RESEARCH funding , *STAINS & staining (Microscopy) , *POSITRON emission tomography , *DIAGNOSIS - Abstract
Positron emission tomography (PET) with fluorodeoxyglucose F18 (18F-FDG) is useful for detecting malignancies, but benign lesions occasionally have false-positive 18F-FDG uptake. Here, we report the cases of five postmenopausal women with solid ovarian tumors suspected to be ovarian cancer on magnetic resonance imaging and 18F-FDG uptake. Mean age of the five patients was 57 years (range, 53-65 years). Average early standardized uptake value (SUV) of 18F-FDG was 5.76 (range, 2.2-12.0) and delayed SUV was 6.56 (range, 2.4-13.8). In all five patients, frozen section diagnosis at surgery was thecoma, and bilateral salpingo-oophorectomy was performed. On immunohistochemistry, immunoreactive glucose transporter 5 (GLUT5) expression was detected in thecoma tissues. This case shows that thecoma sometimes has positive 18F-FDG uptake on positron emission tomography-computed tomography (PET-CT), indicating the need for caution regarding false-positive PET-CT in patients with benign solid ovarian tumor. [ABSTRACT FROM AUTHOR]
- Published
- 2017
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