1. [Update on gastric cancer. New molecular classifications].
- Author
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Díaz Del Arco C, Estrada Muñoz L, Ortega Medina L, and Fernández Aceñero MJ
- Subjects
- Early Detection of Cancer methods, Female, Gene Dosage, Gene Expression Profiling, Helicobacter Infections complications, Helicobacter pylori, Herpesvirus 4, Human, Humans, Japan, Male, Mass Screening organization & administration, Mutation, Neoplasm Staging, Neoplastic Syndromes, Hereditary epidemiology, Republic of Korea, Stomach Neoplasms epidemiology, Stomach Neoplasms surgery, Stomach Neoplasms classification, Stomach Neoplasms genetics
- Abstract
Gastric cancer (GC) is an aggressive tumor, which is usually diagnosed at an advanced stage and shows high mortality rates. Several GC classifications have been published, based on features such as tumor location, endoscopic features or microscopic architecture. However, TNM stage remains the mainstay of GC management and treatment. In the last years, technical advances have allowed us to investigate the biological heterogeneity of GC and develop new molecular classifications. This knowledge may enhance current classifications, and has the potential to refine GC management and aid in the identification of new molecular targets. In this literature review we have summarized the main findings in epidemiology, screening, classification systems and treatment of GC, focusing on the molecular alterations and new molecular classifications published in the last years., (Copyright © 2020 Sociedad Española de Anatomía Patológica. Publicado por Elsevier España, S.L.U. All rights reserved.)
- Published
- 2021
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