1. Successful administration of recombinant human antithrombin in a pregnant Japanese woman with hereditary antithrombin deficiency.
- Author
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Fujibe Y, Mariya T, Mizuuchi M, Ishioka S, Yoshida M, and Saito T
- Subjects
- Adult, Antithrombin III Deficiency complications, Antithrombins administration & dosage, Female, Humans, Infant, Newborn, Injections, Intravenous, Japan, Pregnancy, Pregnancy Outcome, Recombinant Proteins, Venous Thromboembolism etiology, Antithrombin III administration & dosage, Antithrombin III Deficiency drug therapy, Pregnancy Complications, Hematologic, Venous Thromboembolism prevention & control
- Abstract
Objective: Hereditary antithrombin (AT) deficiency increases the risk of venous thromboembolism (VTE) in pregnant woman. We report the first case of administration of recombinant human antithrombin (rhAT) to a pregnant Japanese woman with AT deficiency., Case Report: A 30-year-old woman, gravida 2 para 0, was referred to our hospital because of AT deficiency. Unfractionated heparin was administered from 13 weeks of gestation and rhAT was administered from labor onset. A cesarean section was performed and the patient and her baby were healthy, with no sequelae., Conclusion: We concluded that rhAT was effective for preventing VTE during delivery, with no potential infection risks., (Copyright © 2019. Published by Elsevier B.V.)
- Published
- 2019
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