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Zinc is considered as the fourth important yield limiting nutrient in India, after N, P, and K. From the regular soil analysis data, Indian soils (50%) are found to be deficient in Zn and the zinc deficiency is likely to increase in future. Areas with low soil available Zn are often regions with widespread zinc deficiency in humans. Zinc malnutrition and deficiency in human is alarming and is gaining attention in recent years. Application of zinc to soil and crops is one of the simple and easiest ways to mitigate or alleviate Zn deficiency in human. Moreover Zn uptake, its translocation and yield response of various crops to applied Zn are need to be focused for finding sustainable solutions to the problem of zinc deficiency in crops and humans. In this manuscript, importance of Zn to plants and human, Zn malnutrition problems in India and global level, soil Zn status of Karnataka, various factors that responsible for Zn deficiency in the soils of Karnataka and the response of various horticultural crops to Zn application in the region is discussed. Soil maps are believed to be an important tool to delineate and manage nutrient deficient areas. It also elaborates the effective Zn management strategies to improve crop productivity and farm income. [ABSTRACT FROM AUTHOR]