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Despite entering an endemic phase, SARS-CoV-2 remains a significant burden to public health across the global community. Wastewater sampling has consistently proven utility to understanding SARS-CoV-2 prevalence trends and genetic variation as it represents a less biased assessment of the corresponding communities. Here, we report that ongoing monitoring of SARS-CoV-2 genetic variation in samples obtained from the wastewatersheds of the city of Louisville in Jefferson county Kentucky has revealed the periodic reemergence of the Delta strain in the presence of the presumed dominant Omicron strain. Unlike previous SARS-CoV-2 waves/emergence events, the Delta reemergence events were geographically restricted in the community and failed to spread into other areas as determined by wastewater analyses. Moreover, the reemergence of the Delta strain did not correlate with vaccination rates as communities with lower relative vaccination have been, to date, not affected. Importantly, Delta reemergence events correlate with increased public health burdens, as indicated by increased daily case rates and mortality relative to non-Delta wastewatershed communities. While the underlying reasons for the reemergence of the Delta variant remain unclear, these data reaffirm the ongoing importance of wastewater genomic analyses towards understanding SARS-CoV-2 as it enters the endemic phase. [ABSTRACT FROM AUTHOR]

Information about the papers presented at the ninth annual University of Tennessee (UT)-Oak Ridge National Laboratory (ORNL)-Kentucky Biomedical Research Infrastructure Network (KBRIN) Bioinformatics Summit 2010 held in western Kentucky from March 15 to 21, 2010 is presented. Topics discussed include bioinformatics in Kentucky, DNA microarray analysis, and determination of differences in gene networks between two biological samples. Several professors and medical scientists attended the event.

The article discusses the highlights of the Seventh Annual (University of Tennessee (UT)-Oak Ridge National Laboratory (ORNL)-Kentucky Bioinformatics Network (KBRIN) Bioinformatics Summit held at Lake Barkley State Park in Cadiz, Kentucky from March 28 to 30, 2008. Wayne Matten of the National Center for Biotechnology Information (NCBI) gave a presentation on the association of a diseased gene with a corresponding change in phenotype. Jeremy Smith of ORNL Center for Molecular Physics talked about computer simulation of molecular machines.