1. Microporenic Acids A-G, Biofilm Inhibitors, and Antimicrobial Agents from the Basidiomycete Microporus Species.
- Author
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Chepkirui C, Yuyama KT, Wanga LA, Decock C, Matasyoh JC, Abraham WR, and Stadler M
- Subjects
- Animals, Candida albicans drug effects, Cell Line, Cell Line, Tumor, Gram-Positive Bacteria drug effects, HeLa Cells, Humans, Kenya, Mice, Microbial Sensitivity Tests methods, Staphylococcus aureus drug effects, Anti-Infective Agents pharmacology, Basidiomycota chemistry, Biofilms drug effects
- Abstract
The need for effective compounds to combat antimicrobial resistance and biofilms which play important roles in human infections continues to pose a major health challenge. Seven previously undescribed acyclic diterpenes linked to isocitric acid by an ether linkage, microporenic acids A-G (1-7), were isolated from the cultures of a hitherto undescribed species of the genus Microporus (Polyporales, Basidiomycota) originating from Kenya's Kakamega forest. Microporenic acids D and E (4 and 5) showed antimicrobial activity against a panel of Gram positive bacteria and a yeast, Candida tenuis. Moreover, microporenic acids A and B (1 and 2) demonstrated dose-dependent inhibition of biofilm formation by Staphylococcus aureus. Compound 1 further showed significant activity against Candida albicans and Staphylococcus aureus preformed biofilms.
- Published
- 2018
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