1. Prognostic Value of the Stromal Cell-Derived Factor 1 3.'A Mutation in Pediatric Human Immunodeficiency Virus Type 1 Infection.
- Author
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Tresoldi, Eleonora, Romiti, Maria Luisa, Boniotto, Michele, Crovella, Sergio, Salvatori, Francesca, Palomba, Elvia, Pastore, Angela, Cancrini, Caterina, de Martino, Maurizio, Plebani, Anna, Castelli, Guido, Rossi, Paolo, Tovo, Pier Angelo, Amoroso, Antonio, and Scarlatti, Gabriella
- Subjects
HIV infections ,GENETIC mutation ,VIRAL genetics ,VIRAL diseases in children - Abstract
A mutation of the stromal cell-derived factor 1 gene (SDF-1 3'A) was shown to protect adults exposed to human immunodeficiency virus type 1 (HIV-1) from infection and to affect HIV disease progression in adults. The presence of this mutation in HIV-l-infected Kenyan children did not predict mother-to-child virus transmission. The SDF-1 3'A polymorphism was studied in 256 HIV-l-infected, 118 HIV-l-exposed but uninfected, and 170 unexposed and uninfected children of Italian origin, and the frequency of SDF-1 3'A heterozygosity and homozygosity in each of the 3 groups was similar. Of the 256 HIV-1-infected children, 194 were regularly followed up and were assigned to groups according to disease progression. The frequency of the SDF-1 3'A allele was substantially lower among children with long-term nonprogression than among children with rapid (P = .0329) or delayed (P = .0375) progression. We show that the presence of the SDF-1 3'A gene correlates with accelerated disease progression in HIV-l-infected children born to seropositive mothers but does not protect against mother-to-child HIV1 transmission. [ABSTRACT FROM AUTHOR]
- Published
- 2002