1. Early menarche increases the risk of Type 2 diabetes in young and middle-aged Korean women.
- Author
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Lim, J. S., Lee, H. S., Kim, E. Y., Yi, K. H., and Hwang, J. S.
- Subjects
TYPE 2 diabetes diagnosis ,TYPE 2 diabetes risk factors ,ASIANS ,HOMEOSTASIS ,INSULIN resistance ,MENARCHE ,METABOLISM ,TYPE 2 diabetes ,PROFESSIONAL associations ,SERIAL publications ,SURVEYS - Abstract
Aims To investigate the association between early menarche (menarche age < 12 years) and Type 2 diabetes mellitus in young and middle-aged Korean women. Methods We analysed data for 4657 women aged 20-50 years from the Fourth Korea National Health and Nutrition Examination Survey ( KNHANES IV) (2007-2009). Results The prevalence of Type 2 diabetes was 2.8%. Women with early menarche had a higher prevalence of impaired fasting glucose than did women with later menarche (age ≥ 12 years) in the 20-30 age group (7.4% vs. 3.0%), and a higher prevalence of diabetes in the 30-40 (6.3% vs. 1.7%) and 40-50 (18.5% vs. 4.4%) age groups. The odds ratio ( OR) of Type 2 diabetes in women with early menarche was 3.61 [95% confidence interval ( CI), 1.90-6.88] after adjusting for age. In multivariate regression, the OR of Type 2 diabetes decreased to 2.52 (95% CI, 1.29-4.94) after further adjusting for BMI. However, the OR decreased to 2.04 (95% CI, 0.95-4.39) without significance after adjusting for HOMA- IR. Conclusions Early menarche increased the risk of Type 2 diabetes in young and middle-aged Korean women although adulthood adiposity attenuated the relationship. Knowledge of age at menarche is important in identifying women at risk for diabetes. [ABSTRACT FROM AUTHOR]
- Published
- 2015
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