6 results on '"Jeong DH"'
Search Results
2. Complete genome sequence of Bacillus anthracis H9401, an isolate from a Korean patient with anthrax.
- Author
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Chun JH, Hong KJ, Cha SH, Cho MH, Lee KJ, Jeong DH, Yoo CK, and Rhie GE
- Subjects
- Anthrax microbiology, Bacillus anthracis isolation & purification, Gastrointestinal Diseases microbiology, Humans, Korea, Molecular Sequence Data, Open Reading Frames, Plasmids, Sequence Homology, Synteny, Bacillus anthracis genetics, DNA, Bacterial chemistry, DNA, Bacterial genetics, Genome, Bacterial, Sequence Analysis, DNA
- Abstract
Bacillus anthracis H9401 (NCCP 12889) is an isolate from a Korean patient with gastrointestinal anthrax. The whole genome of H9401 was sequenced. It is a circular chromosome containing 5,480 open reading frames (ORFs) and two plasmids, pXO1 containing 202 ORFs and pXO2 containing 110 ORFs. H9401 shows high pathogenicity and genome sequence similarity to Ames Ancestor.
- Published
- 2012
- Full Text
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3. Preoperative identification of a low-risk group for lymph node metastasis in endometrial cancer: a Korean gynecologic oncology group study.
- Author
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Kang S, Kang WD, Chung HH, Jeong DH, Seo SS, Lee JM, Lee JK, Kim JW, Kim SM, Park SY, and Kim KT
- Subjects
- Adult, Aged, Aged, 80 and over, Analysis of Variance, Biopsy, Needle, Cohort Studies, Confidence Intervals, Endometrial Neoplasms mortality, Female, Humans, Hysterectomy methods, Immunohistochemistry, Korea, Logistic Models, Lymph Node Excision, Lymphatic Metastasis, Middle Aged, Multivariate Analysis, Neoplasm Invasiveness pathology, Predictive Value of Tests, Preoperative Care methods, Prognosis, Reproducibility of Results, Retrospective Studies, Risk Assessment, Survival Analysis, Treatment Outcome, CA-125 Antigen blood, Endometrial Neoplasms pathology, Endometrial Neoplasms surgery, Lymph Nodes pathology, Magnetic Resonance Imaging methods
- Abstract
Purpose: The aim of this study was to develop a preoperative risk prediction model for lymph node metastasis in patients with endometrial cancer and to identify a low-risk group before surgery., Patients and Methods: The medical records of 360 patients with endometrial cancer who underwent surgical staging were collected from four institutions and were retrospectively reviewed. By using serum CA-125 levels, preoperative biopsy data, and magnetic resonance imaging (MRI) data, a multivariate logistic model was created. Patients whose predicted probability was less than 4% were defined as low risk. The developed model was externally validated in 180 patients from two independent institutions., Results: Serum CA-125 levels and three MRI parameters (deep myometrial invasion, lymph node enlargement, and extension beyond uterine corpus) were found to be independent risk factors for nodal metastasis. The model classified 53% of patients as part of a low-risk group, and the false negative rate was 1.7%. In the validation cohort, the model classified 43% of patients as low-risk, and the false negative rate was 1.4%. The model showed good discrimination (area under the receiver operator characteristic curve = 0.85) and was calibrated well. The negative likelihood ratio of our low-risk criteria was 0.11 (95% CI, 0.04 to 0.29), which was equivalent to the false-negative rate of 1.3% (95% CI, 0.5% to 3.3%) at the assumed prevalence of nodal metastasis of 10%., Conclusion: Using serum CA-125 and MRI as criteria resulted in the accurate identification of a low-risk group for lymph node metastasis among patients with endometrial cancer.
- Published
- 2012
- Full Text
- View/download PDF
4. The risk of lymph node metastasis based on myometrial invasion and tumor grade in endometrioid uterine cancers: a multicenter, retrospective Korean study.
- Author
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Lee KB, Ki KD, Lee JM, Lee JK, Kim JW, Cho CH, Kim SM, Park SY, Jeong DH, and Kim KT
- Subjects
- Adult, Aged, Aged, 80 and over, Endometrial Neoplasms surgery, Female, Follow-Up Studies, Humans, Korea, Lymph Node Excision, Lymphatic Metastasis, Male, Middle Aged, Myometrium surgery, Neoplasm Staging, Prognosis, Retrospective Studies, Risk Factors, Survival Rate, Treatment Outcome, Young Adult, Endometrial Neoplasms pathology, Myometrium pathology
- Abstract
Background: Knowledge of the risk factors for lymph node metastasis (LNM) is necessary to treat patients with endometrioid uterine cancer to optimize and further individualize treatment. This study was designed to determine the risk of LNM based on myometrial invasion and tumor grade in endometrioid uterine cancer., Methods: The authors retrospectively reviewed the medical records and pathological findings of 834 patients who underwent surgical staging, including pelvic lymphadenectomy with or without para-aortic lymphadenectomy, for endometrioid uterine cancer from 2002 to 2008 in Korea., Results: Of the 834 patients with endometrioid uterine cancer, 107 (12.8%) patients had LNM. Sixty-one (57%) patients had only pelvic LNM, 39 (36.4%) had pelvic and para-aortic LNM, and 7 (6.6%) had isolated para-aortic LNM. Tumor grade, myometrial invasion, tumor diameter, cervical extension, lymphovascular space invasion, and adnexal involvement were found to be significant predictors of LNM. Of 215 patients with no myometrial invasion and tumor grade I/II, only 1 (0.47%) had LNM. However, in other patients, the risk of LNM was significant and at least > 3.5%. Furthermore, the risk of LNM was found to be well correlated with increases in myometrial invasion and tumor grade based on subgroup analyses, when patients with no myometrial invasion and tumor grade I/II were used as a reference group (p < 0.0001)., Conclusions: Patients with endometrioid uterine cancers with no myometrial invasion and tumor grade I/II might have minimal risk of LNM, whereas others might require complete pelvic and para-aortic lymphadenectomy for surgical staging.
- Published
- 2009
- Full Text
- View/download PDF
5. Fetal bladder outlet obstruction in a stillborn bovine fetus.
- Author
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Jeong WI, Lee CS, Chung JY, Park SJ, An MY, Jeong DH, Do SH, Noh DH, Williams BH, and Jeong KS
- Subjects
- Abnormalities, Multiple embryology, Animals, Cattle, Hydronephrosis congenital, Hydronephrosis embryology, Korea, Male, Urinary Bladder embryology, Fetal Death, Fetal Diseases, Fetus abnormalities, Urinary Bladder abnormalities, Urinary Bladder Neck Obstruction congenital
- Abstract
A stillborn bovine male fetus with abdominal distention, arthrogryposis and atresia ani was presented for diagnostic evaluation. At necropsy, this fetus had a large amount of ascites, urachal obstruction and marked bladder distention. The ventral surface of the bladder had ruptured and attached to the abdominal wall by fibrinous adhesions. There was bilateral hydronephrosis with moderate pelvic dilatation and cortical attenuation. The rectum was filled with meconium but the anus was imperforate. The right forelimb was contracted. The cause(s) of these abnormalities could not be determined; however, we believe that developmental abnormalities during embryogenesis may be the result of chromosomal abnormalities.
- Published
- 2003
- Full Text
- View/download PDF
6. Prolonged airway and systemic inflammatory reactions after smoke inhalation.
- Author
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Park GY, Park JW, Jeong DH, and Jeong SH
- Subjects
- Adolescent, Bronchial Hyperreactivity diagnosis, Bronchial Hyperreactivity immunology, Bronchial Provocation Tests, Bronchoalveolar Lavage Fluid immunology, Cross-Sectional Studies, Female, Fires, Follow-Up Studies, Humans, Interferon-gamma blood, Interleukin-2 blood, Korea, Male, Systemic Inflammatory Response Syndrome diagnosis, Tumor Necrosis Factor-alpha metabolism, Inflammation Mediators blood, Smoke Inhalation Injury immunology, Systemic Inflammatory Response Syndrome immunology
- Abstract
Study Objectives: Smoke inhalation has a prolonged, negative effect on pulmonary function. The immediate change in the airway after smoke inhalation is an intense inflammatory reaction. Obstructive airway disease commonly occurs several years after smoke inhalation, but few studies have focused on long-term reactions in the airway. This study investigated the long-term effects of smoke inhalation, by examining airway responsiveness, airway inflammation, and systemic effects., Design: Cross-sectional study., Patients: We assessed victims (n = 9) of smoke inhalation 6 months after they were exposed., Interventions: We studied the clinical symptoms, laboratory data, and pulmonary functions of the patients. We also performed the nonspecific bronchial challenge test with methacholine on these patients. In some patients, we reviewed pathologic specimens of bronchi and measured cytokines (tumor necrosis factor [TNF]-alpha, interferon [INF]-gamma, and interleukin [IL]-2) in serum and BAL fluid., Results: All the subjects complained of a productive cough, and three subjects had a mild degree of dyspnea on exertion. All but one subject had airway hyperresponsiveness to methacholine. The pulmonary function test results, however, were within normal limits, except for one subject who had a mild obstructive pattern of pulmonary function. Bronchial mucosal biopsy (n = 2) showed inflammatory changes with lymphocyte infiltration. Significantly greater concentrations of TNF-alpha (mean, 1,346.4 pg/mL vs 61.2 pg/mL; p < 0.05) and IFN-gamma (mean, 540.9 pg/mL vs 26.7 pg/mL; p < 0.05) were seen in the serum (n = 4) compared with control subjects. The serum IL-2 level was also increased (mean, 136.8 pg/mL vs undetectable); however, the increase was not significant compared with the control subjects., Conclusions: These data suggest that inflammatory reactions in the airways and peripheral blood continue for at least 6 months after smoke inhalation.
- Published
- 2003
- Full Text
- View/download PDF
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