1. The Association of Sex Hormone and the Metabolic Syndrome in Healthy Korean Males.
- Author
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Eun-Jung Rhee, Se-Yeon Kim, Chan-Hee Jung, Cheol Young Park, Won-Young Lee, Ki-Won Oh, Sung-Woo Park, and Sun-Woo Kim
- Subjects
METABOLIC syndrome ,SEX hormones ,TYPE 2 diabetes risk factors ,CARDIOVASCULAR diseases ,MEN'S health ,ANDROGENS ,HIGH density lipoproteins - Abstract
Background: Metabolic syndrome is a strong risk factor for type 2 diabetes mellitus and cardiovascular disease and its prevalence is markedly increasing. Recent studies report the association of androgen deficiency with the development of metabolic syndrome. We analyzed the association of serum lipid profiles and metabolic syndrome in apparently healthy Korean male adults. Methods: Among the participants in the annual health check-up program in Health Promotion Center in Kangbuk Samsung Hospital from March to May, 2003, 290 male adults (mean age 40 years, range 28-69 years) were selected and anthropometric measurements, blood pressure, fasting blood glucose, fasting insulin serum lipid profiles, sex hormone binding globulin (SHBG) and total testosterone levels were measured. The presence of metabolic syndrome was defined by National Cholesterol Education Program-Adult Treatment Panel (NCEP-ATP) III criteria. Results: In bivariate analysis, SHBG showed positive correlation with age and serum high-density lipoprotein cholesterol (HDL-C) and negative correlation with body mass index (BMI), triglyceride, uric acid, fasting insulin, blood pressure. Serum total testosterone level showed positive correlation with HDL-C level and negative correlation with triglyceride, uric acid, fasting insulin and diastolic blood pressure. After the adjustment for age and BMI, serum testosterone level showed significant correlation with uric acid and HDL-C level and SHBG level showed significant correlation with uric acid, triglyceride, insulin and diastolic blood pressure. In logistic regression analysis, the 3rd lowest quartile of total testosterone level showed odds ratio of 0.304 (95% CI 0.112∼0.824) for metabolic syndrome compared with the lowest quartile. The highest quartile of SHBG level showed odds ratio of 0.224 (95% CI 0.070∼0.712) compared with the lowest quartile. Conclusions: In apparently healthy Korean male adults, serum total testosterone level showed significant correlation with serum lipid levels and as the levels of testosterone and SHBG increased, the risk for metabolic syndrome was decreased. [ABSTRACT FROM AUTHOR]
- Published
- 2007