1. The C19007T polymorphism of ERCC1 and its correlation with the risk of epithelial ovarian and endometrial cancer in Korean women. A case control study.
- Author
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Jo H, Kang S, Kim SI, Kim JW, Park NH, Song YS, Park SY, Kang SB, and Lee HP
- Subjects
- Adolescent, Adult, Aged, Case-Control Studies, Chi-Square Distribution, Endometrial Neoplasms epidemiology, Endometrial Neoplasms pathology, Female, Genotype, Humans, Korea epidemiology, Logistic Models, Middle Aged, Neoplasms, Glandular and Epithelial epidemiology, Neoplasms, Glandular and Epithelial pathology, Odds Ratio, Ovarian Neoplasms epidemiology, Ovarian Neoplasms pathology, Prospective Studies, Risk Factors, DNA-Binding Proteins genetics, Endometrial Neoplasms genetics, Endonucleases genetics, Neoplasms, Glandular and Epithelial genetics, Ovarian Neoplasms genetics, Polymorphism, Genetic
- Abstract
Background: Excision repair cross-complementing group 1 (ERCC1) is a major DNA repair protein. Recent studies have addressed the association between ERCC1 polymorphism and carcinogenesis., Methods: We investigated a polymorphism of ERCC1 at nucleotide 19007 (C-->T, Asn118Asn) in 94 epithelial ovarian cancer patients, 102 endometrial cancer patients, and in 329 control subjects., Results: We observed no evidence of associations between the C19007T ERCC1 polymorphism and risk of epithelial ovarian or endometrial cancer, which had the same adjusted odds ratios of 0.91 (p = 0.711, 0.691 respectively)., Conclusion: Our findings suggest that the C19007T ERCC1 polymorphism is unlikely to play an important role in epithelial ovarian or endometrial cancer in Korean women., (2007 S. Karger AG, Basel)
- Published
- 2007
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