1. The cefazolin inoculum effect in methicillin-susceptible Staphylococcus aureus blood isolates: their association with dysfunctional accessory gene regulator (agr).
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Wi, Yu Mi, Park, Young Kyoung, Moon, Chisook, Ryu, Seong Yeol, Lee, Hyuck, Ki, Hyun Kyun, Cheong, Hae Suk, Son, Jun Seong, Lee, Jin Seo, Kwon, Ki Tae, Kim, June Myong, Ha, Young Eun, Kang, Cheol In, Ko, Kwan Soo, Chung, Doo Ryeon, Peck, Kyong Ran, and Song, Jae-Hoon
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CEFAZOLIN , *METHICILLIN-resistant staphylococcus aureus , *BLOOD microbiology , *GENETIC regulation , *PATIENTS - Abstract
We evaluated the clinical significance of the cefazolin inoculum effect (CIE) in methicillin-susceptible Staphylococcus aureus (MSSA) isolates. In total, 146 isolates were recovered from patients with MSSA bacteremia at 9 hospitals in Korea. The CIE was observed in 16 MSSA isolates, and while type A was the only detected β-lactamase in MSSA isolates exhibiting the CIE, no strains expressing type B, C, or D β-lactamases exhibited this effect. The CIE was only observed in agr group III and I isolates and was significantly more common in isolates with agr dysfunction than in those with functional agr ( P < 0.001). Even among isolates producing type A β-lactamase, the CIE was also prevalent in isolates with dysfunctional agr than in isolates with functional agr ( P = 0.025). This study demonstrates an association between the CIE of MSSA isolates and agr dysfunction, in addition to those between the CIE and type A β-lactamase. [ABSTRACT FROM AUTHOR]
- Published
- 2015
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