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Objective: To determine the relationship between the prostate volume and the serum values of prostate specific antigen among patients in the "grey zone", classified according to their age group. Gray zone represents serum prostate specific antigen values between 4.1 ng/ml to 10 ng/ml. Material and Methods: Prospective and retrospective 1420 patients classified in four age-groups with LUTS (Lower Urinary Tract Symptoms) were analyzed. Patients were treated for Benign Prostate Hyperplasia (BPH) in the urology clinical at the University Clinical Center of Kosovo during the period of January 2010-October 2020. Data were recorded from patients according to age, prostate size estimated by trans abdominal ultrasound using 3.5 MHz ultrasonography, according to the ellipsoid formula, V = D1 × D2 × D3/2.5, Volume of prostate (V)=T × AP × CC × Pi/6 where T=Transverse diameter, AP=Antero Posterior diameter, CC=Cranial Caudal diameter. Patients with confirmed prostate cancer were excluded from the study. Statistical analyses used t-test and ANOVA (Analysis of Variance) with 95% and 99% confidence intervals. Results: For the grey zone patients, these mean values were 44.6 cm3 and 5.9 ng/mL. Conclusions: The data provide evidence to support that prostate volume and serum Prostate Specific Antigen (PSA) concentration significantly correlate with aging and within the grey zone patients. [ABSTRACT FROM AUTHOR]