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There is a lack of information correlating low adiposity with hypertension experienced by Spontaneous Hypertensive Rats (SHR) or overweight and normotension in Wistar-Kyoto (WKY). We aimed to investigate this lipodystrophy phenomenon by measuring fluorescence lifetime (FLIM), optical redox ratio (ORR), serum levels of hypothalamic–pituitary–adrenal (HPA) and/or hypothalamic–pituitary–thyroid (HPT) hormones axes between Wistar, WKY and SHR before and after establishment of hypertension. Under high blood pressure, we evaluated serum adipokines. Brown adipose tissue was characterized as lower ORR and shorter FLIM compared to white adipose tissue. HPT axis showed a crucial role in the SHR adipose tissue configuration by attenuating whitening. The increased adiposity in WKY may act as a preventive agent for hypertension, since SHR, with low adiposity, establishes the disease. The hypertensive environment can highlight key adipokines that may result in new therapeutic approaches to the treatment of adiposity dysfunctions and hypertension. • Adipose pads exhibited distinct optical signatures associated with their function. • Brown adipocytes became characteristically more like white adipocytes over time. • Whitening phenomenon may be attenuated by the HPT-T3 axis. • Increased adiposity in WKY may be acting as a preventive agent for hypertension. [ABSTRACT FROM AUTHOR]