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Many requirements have been proposed for pollution control in a legal, scientific and targeted way. At the critical stage of pollution prevention and control, refined management of industrial pollution is a way of achieving targeted pollution control. Focusing regional pollution reduction targets on industrial production processes with reduction emission potential is an effective way to achieve targeted control. We established a source-processing-end (S–P-E) coordinated model—SPECM—by collaboratively considering the whole-process of raw material-processing-end-of-pipe (EOP) chains and applied the model to the setting of medium- and long-term pollution control targets and selection of reduction options for various industries in Lanzhou, China. The results indicated that (1) chemical manufacturing-related industries are the key potential volatile organic compound (VOC) emission reduction industries in Lanzhou, accounting for approximately 89% of the total emission reduction potential; (2) metal furniture manufacturing and paper-making industries should strengthen processing optimization while also giving attention to material substitution; and (3) printing-related industries need collaborative control of their whole-process, especially material substitution enhancement. The SPECM method focuses on the reduction in industrial processes and proposes reduction options under different reduction targets. This new collaborative control method could facilitate the design of coordinated control schemes across industries under industrial emission reduction targets. Overall, our results could provide new ideas and guidance for the refined management of regional industrial pollution. [Display omitted] • Emission reduction focuses on production process improves the reduction targeting. • Collaborative control helps to design coordinated cross-industry control strategies. • VOC control in chemical manufacturing-related industries is urgent in Lanzhou. • Metal furniture manufacturing and paper industries should enhance process reduction. • Source reduction contributes greatly to VOC reduction in printing industry. [ABSTRACT FROM AUTHOR]

• Source reduction contributes greatly to VOC emission reduction. • A comprehensive assessment system helps tailor effective VOC control strategies. • A comprehensive assessment system helps to improve reduction targeting. • Synergistic control of the overall process promotes VOC reduction benefits. Strong volatile organic compound (VOCs) emissions from solvent-using industries are one of the most pressing environmental challenges in China, and urgently require a cost-effective and carbon-reduction benefit synergistic control strategy. Here, we proposed a novel comprehensive assessment system to optimize a whole-process control strategy that can simultaneously meet triple goals of reduction potential, cost-benefits, and carbon reduction. By focusing on Inner Mongolia Autonomous Region, Shenzhen City, Lanzhou City, Nanyang City and Shunde District of Foshan City, each exhibiting different emission characteristics in packaging and printing (P&P) industry, we proposed various synergistic control strategies and options for reduction potential, cost-benefits, and carbon reduction. This new comprehensive assessment system was shown to be beneficial for obtaining a coordinated control option with better comprehensive effects. Overall our results indicate how to formulate efficient policies, optimized for different regions, to mitigate VOC pollution in industrial sectors. [Display omitted] [ABSTRACT FROM AUTHOR]