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A comprehensive study of the sediment source-to-sink history of basins arranged along the Bangong-Nujiang Suture Zone (BNSZ) is critical for understanding the early Cenozoic topography and drainage systems of central Tibet and its implications for the uplift history of the Tibetan Plateau. Nevertheless, previous provenance analyses work mainly focused on the middle-eastern segment of the BNSZ, those Paleogene basins in the western segment have received less attention, which hinders a full understanding of the early Cenozoic topography of central Tibet. In this study, based on a chronostratigraphic framework developed for the lower Cenozoic continental redbeds of the Gaize Basin, we applied detrital zircon U-Pb geochronology to the well-exposed Paleogene Suonahu Formation in order to reconstruct the basin's source-to-sink history. Integrating these new data with detrital zircon U-Pb results from the underlying Kangtuo Formation, we recognize a major secular shift in sediment provenance characterized by inputs of Lhasa-derived clasts during the Late Eocene. Moreover, we applied statistical analysis to compare the U-Pb age spectra of Eocene strata in the Gaize-Nima-Lunpola basins in order to assess similarities between them and potential source regions. Our study confirms a paleogeographic scenario in which these Paleogene basins most likely were part of a low-elevation intermontane valley. • Analysis of detrital zircon U-Pb geochronology of Paleogene strata in Gaize Basin. • A major shift in provenance occurred between the Kangtuo and Suonahu formations. • Cenozoic clastic strata in the Gaize-Nima-Lunpola basins share a similar provenance. • The Gaize-Nima-Lunpola basins belonged to a Paleogene low-elevation valley. [ABSTRACT FROM AUTHOR]