1. Invasive chromoblastomycosis and sinusitis due to Phialophora verrucosa in a child from northern Africa.
- Author
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Hofmann H, Choi SM, Wilsmann-Theis D, Horré R, de Hoog GS, and Bieber T
- Subjects
- Antifungal Agents administration & dosage, Antifungal Agents therapeutic use, Child, DNA, Fungal chemistry, DNA, Fungal genetics, DNA, Ribosomal Spacer chemistry, DNA, Ribosomal Spacer genetics, Female, Humans, Itraconazole administration & dosage, Itraconazole therapeutic use, Libya, Phialophora cytology, Phylogeny, Sequence Analysis, DNA, Sequence Homology, Nucleic Acid, Sinusitis pathology, Upper Extremity microbiology, Upper Extremity pathology, Chromoblastomycosis microbiology, Chromoblastomycosis pathology, Face microbiology, Face pathology, Phialophora isolation & purification, Sinusitis microbiology
- Abstract
We report on a severe, verrucous facial mycosis and sinusitis in a 12-year-old Libyan girl. Her disease started with verrucous, hyperkeratotic plaques and subcutaneous violet nodules of unknown origin on her face and upper extremities. Despite topical antimycotic therapy she needed in-hospital treatment because of severely progressive tumorous cutaneous and nasal lesions. Microscopic examination of scale samples taken from the upper extremities and the face revealed brown, thick-walled fungal elements. Under the assumption of a chromoblastomycosis, an oral treatment with itraconazole and fluorocytosin was initiated, with significant improvement of the lesions. The aetiological agent was identified as Phialophora verrucosa.
- Published
- 2005
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