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Saarland and Lorraine are peripherial regions at the German-French border with similar economic problems. Both regions are trying to compensate for job losses in the coal, iron and steel industry by building up new industrial networks and by establishing an 'up-grading' strategy following the innovative models of high-tech regions. In the following article I will discuss the risks and opportunities of these regional economic policies, in particular the chances of gaining possible inter-regional advantages and synergies through cross-border networking activities. [ABSTRACT FROM AUTHOR]