1. Cross-sectional study examining household factors associated with SARS-CoV-2 seropositivity in low-income children in Los Angeles.
- Author
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Doctor JN, Berg AH, Knight TK, Kadono M, Stewart E, Sonik R, Hochman M, and Sood N
- Subjects
- Adolescent, Adult, Humans, Child, SARS-CoV-2, Los Angeles epidemiology, Cross-Sectional Studies, Antibodies, Viral, Seroepidemiologic Studies, COVID-19 epidemiology, Diabetes Mellitus, Type 2
- Abstract
Objectives: This study aims to quantify the degree to which an underserved, Hispanic population in Los Angeles is impacted by SARS-CoV-2, and determine factors associated with paediatric seropositivity., Design: Cross-sectional., Setting: AltaMed, a Federally Qualified Health Center in Los Angeles., Participants: A random sample of households who had received healthcare at AltaMed Medical Group was invited to participate. Households with at least one adult and one paediatric participant between 5 and 17 years of age were eligible to participate. Consented participants completed a survey on social determinants of health and were tested for antibodies using Abbott Architect SARS-CoV-2-IgG and SARS-CoV-2-IgM tests., Primary Outcome Measure: Seropositive status., Results: We analysed 390 adults (mean age in years, 38.98 (SD 12.11)) and 332 paediatric participants (11.26 (SD 3.51)) from 196 households. Estimated seropositivity was 52.11% (95% CI 49.61% to 55.19%) in paediatric participants and 63.58% (95% CI 60.39% to 65.24%) in adults. Seropositivity was 11.47% (95% CI 6.82% to 14.09%) lower in paediatric participants, but high relative to other populations. A household member with type 2 diabetes (OR 2.94 (95% CI 1.68 to 5.14)), receipt of food stamps (OR 1.66 (95% CI 1.08 to 2.56)) and lower head-of-household education (OR 1.73 (95% CI 1.06 to 2.84)) were associated with paediatric seropositivity., Conclusions: SARS-CoV-2 seropositivity is high in Hispanic children and adolescents in Los Angeles. Food insecure households with low head-of-household education, and at least one household member with type 2 diabetes, had the highest risk. These factors may inform paediatrician COVID-19 mitigation recommendations., Trial Registration Number: NCT04901624., Competing Interests: Competing interests: None declared., (© Author(s) (or their employer(s)) 2023. Re-use permitted under CC BY-NC. No commercial re-use. See rights and permissions. Published by BMJ.)
- Published
- 2023
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