1. Bioactive constituents of Cedrelopsis microfoliata.
- Author
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Koorbanally NA, Randrianarivelojosia M, Mulholland DA, Quarles van Ufford L, and van den Berg AJ
- Subjects
- Benzene Derivatives chemistry, Benzene Derivatives pharmacology, Cells, Cultured drug effects, Free Radical Scavengers chemistry, Free Radical Scavengers pharmacology, Humans, Kidney, Luciferases metabolism, Luminescent Measurements, Madagascar, Molecular Structure, Nuclear Magnetic Resonance, Biomolecular, Plant Bark chemistry, Plant Stems chemistry, Receptors, Estrogen metabolism, Benzene Derivatives isolation & purification, Free Radical Scavengers isolation & purification, Plants, Medicinal chemistry, Sapindaceae chemistry
- Abstract
The stem bark of Cedrelopsis microfoliata has yielded the new compounds microfolian (1), microfolione (2), and microfolicoumarin (6) along with the known compounds agrandol (3), cedrecoumarin A (4), obliquin (5), and sesquichamaenol (7). Compounds 2-4 were found to show agonistic activity on both alpha- and beta-estrogenic receptors, and compounds 1, 3, and 4 were shown to inhibit the chemiluminescence of reactive oxygen metabolites and showed superoxide scavenging activity.
- Published
- 2002
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